Dermal substitution in acute burns and reconstructive surgery: a subjective and objective long-term follow-up.

Abstract:

:Tissue engineering and dermal substitution are currently prominent topics of wound-healing research. However, no extensive clinical trials with objective evaluation criteria have been published so far that support the clinical effectiveness of dermal equivalents in the long term. The dermal substitute that is discussed here is derived from bovine collagen and elastin-hydrolysate and has been shown to improve skin elasticity during a short-term clinical follow-up of scar reconstructions. In this study we will present the long-term outcome by means of objective and subjective scar assessment tools for dermal substitution in acute burn wounds and scar reconstructions. In a clinical trial, an intraindividual comparison was performed between the conventional split-thickness autograft and a combination of the collagen/elastin substitute with an autograft. After 1 year, scars were evaluated by the Cutometer SEM 474 for objective elasticity measurements and by planimetry to establish scar contraction. An independent observer subjected scars to a generally accepted clinical scar assessment tool: the Vancouver Scar Scale. In addition, patients gave their impression of the outcome. Forty-two paired burn wounds and 44 paired scar reconstructions were included and evaluated 1 year after surgery. Although substituted scar reconstructions demonstrated an elasticity improvement of approximately 20 percent compared with control wounds, no statistically significant differences were found for skin elasticity, scar contraction, Vancouver Scar Scale, and patient's impression in both categories after 1 year. An extensive long-term follow-up shows that the dermal substitute, which was proven effective in a clinical trial on a short-term basis, did not yield statistical evidence for a long-term clinical effectiveness of dermal substitution.

journal_name

Plast Reconstr Surg

authors

van Zuijlen PP,Vloemans JF,van Trier AJ,Suijker MH,van Unen E,Groenevelt F,Kreis RW,Middelkoop E

doi

10.1097/00006534-200112000-00014

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

1938-46

issue

7

eissn

0032-1052

issn

1529-4242

journal_volume

108

pub_type

临床试验,杂志文章
  • Method for immediate measurement of skin removed during rhytidectomies.

    abstract::A method for measuring skin removed during rhytidectomy is presented based on analysis of 50 female patients. More skin was removed in primary rhytidectomies than in subsequent ones. Younger patients, aged 30 to 39 years, had measurably more skin removed than any other group between 40 and 69. The amounts of skin remo...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198204000-00005

    authors: Lewis CM

    更新日期:1982-04-01 00:00:00

  • Analysis and classification of the upper lip aesthetic unit.

    abstract:BACKGROUND:Disharmonies of the upper lip aesthetic unit generally stem from tall ergotrids and/or thin lips. Comprehension and correction of such defects has been stifled by a lack of metrics and organized systems of diagnosis and treatment. METHODS:The philtral-labial score was devised to better analyze the upper lip...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31829accb6

    authors: Raphael P,Harris R,Harris SW

    更新日期:2013-09-01 00:00:00

  • The increasing incidence of melanoma.

    abstract::A study of our hospital records has confirmed a striking increase in the number of melanoma cases. An examination of the New York State statistics demonstrates a 202 percent increase in the case rate from 1950 to 1971. The Connecticut statistics extending from 1935 to 1972 show an age-adjusted incidence rate increase ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197601000-00010

    authors: Cosman B,Heddle SB,Crikelair GF

    更新日期:1976-01-01 00:00:00

  • Fat necrosis in deep inferior epigastric perforator flaps: an ultrasound-based review of 202 cases.

    abstract:BACKGROUND:In autologous breast reconstruction after mastectomy, fat necrosis is a rather common complication that may lead to secondary corrective surgery. The understanding of fat necrosis until now has been limited because previous studies were based exclusively on physical examination and used diverse definitions. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181bf7e03

    authors: Peeters WJ,Nanhekhan L,Van Ongeval C,Fabré G,Vandevoort M

    更新日期:2009-12-01 00:00:00

  • The association between breast surgeons' attitudes toward breast reconstruction and their reconstruction-related information-giving behaviors: a nationwide survey in Japan.

    abstract:BACKGROUND:Breast reconstruction after breast cancer surgery has come to be regarded as an achievable treatment option to improve patients' quality of life. Although it has been pointed out that surgeons' information-giving behaviors affect women's decision to undergo breast reconstruction surgery, little is known abou...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000233149.36751.d2

    authors: Takahashi M,Kai I,Hisata M,Higashi Y

    更新日期:2006-12-01 00:00:00

  • Mandibular reconstruction with the titanium hollow screw reconstruction plate (THORP) system: evaluation of 62 cases.

    abstract::The titanium hollow screw reconstruction plate (THORP) system for reconstruction of lower jaw defects provides a functional stable fixation and is used as a long-term or permanent implant in tumor surgery and in traumatology. The rigid fixation of the head of the screw to the plate, avoiding unphysiologic loads to the...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198811000-00013

    authors: Vuillemin T,Raveh J,Sutter F

    更新日期:1988-11-01 00:00:00

  • Shaping the breast in aesthetic and reconstructive breast surgery: an easy three-step principle. Part IV--aesthetic breast surgery.

    abstract:SUMMARY:This is part IV of four articles describing the three-step principle for easy shaping of the breast in reconstructive and aesthetic breast surgery. This article may seem overdue because aesthetic corrections are routinely performed, frequently written about, and easier to execute, as no prior ablative surgery o...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181aeeb21

    authors: Blondeel PN,Hijjawi J,Depypere H,Roche N,Van Landuyt K

    更新日期:2009-08-01 00:00:00

  • SMAS autografts for the nasal dorsum.

    abstract::Many patients of rhytidectomy age have had previous rhinoplasty or nasal injury and have dorsal irregularities or saddle-nose deformities. SMAS tissue ordinarily discarded at rhytidectomy may be used for nasal dorsal augmentation and padding. Six patients undergoing rhytidectomy who also had prior nasal surgery or def...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199605000-00025

    authors: Leaf N

    更新日期:1996-05-01 00:00:00

  • Long-Term Outcomes of Total Knee Arthroplasty following Soft-Tissue Defect Reconstruction with Muscle and Fasciocutaneous Flaps.

    abstract:BACKGROUND:Insufficient soft-tissue coverage following total knee arthroplasty jeopardizes prosthesis retention and may lead to significant complications. The aim of this study was to evaluate the natural history of total knee arthroplasty following flap reconstruction of soft-tissue defects. METHODS:A retrospective r...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000001929

    authors: Kwiecien GJ,Lamaris G,Gharb BB,Murray T,Hendrickson MF,Zins JE,Isakov R

    更新日期:2016-01-01 00:00:00

  • Extended approach to the vascular pedicle of the gracilis muscle flap: anatomical and clinical study.

    abstract::Dissection of the proximal gracilis vascular pedicle proceeds in a dark tunnel-like space deep to the adductor longus. With the application of a previously described technique for an extended approach to the lateral arm free flap, the authors describe a novel technique that improves observation and thus facilitates di...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.PRS.0000060114.95065.C5

    authors: Hasen KV,Gallegos ML,Dumanian GA

    更新日期:2003-06-01 00:00:00

  • Umbilicus Reconstruction with Bilateral Square "Pumpkin-Teeth" Advancement Flaps.

    abstract::The creation of a neoumbilicus is a common challenge for plastic surgeons. The authors present their technique of umbilical reconstruction with bilateral square "pumpkin-teeth" advancement flaps. The technique described is applicable in both the setting of a vertical midline incision and when no midline incision is pr...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0000000000003929

    authors: Purnell CA,Turin SY,Dumanian GA

    更新日期:2018-01-01 00:00:00

  • Evaluation of tests for predicting the viability of axial pattern skin flaps in the pig.

    abstract::The viability of axial pattern skin flaps in pigs was assessed by the use of intravenous fluorescein, intradermal injection of 133Xe in saline, intravenous 51Cr tagged red cells, and angiography. The results were correlated with flap survival at 4 days postoperatively. Intravenous fluorescein provided the most accurat...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197902000-00016

    authors: Prather A,Blackburn JP,Williams TR,Lynn JA

    更新日期:1979-02-01 00:00:00

  • Speech prosthesis versus pharyngeal flap: a randomized evaluation of the management of velopharyngeal incompetency.

    abstract::Thirty-nine children with moderate-to-severe velopharyngeal incompetency were randomly assigned to either prosthetic or surgical palatal management. A classification for evaluating velopharyngeal incompetency was designed. The prosthetic speech appliance, when obtained and tolerated, corrected velopharyngeal incompete...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198005000-00009

    authors: Marsh JL,Wray RC

    更新日期:1980-05-01 00:00:00

  • The incidence of tuberous breast deformity in asymmetric and symmetric mammaplasty patients.

    abstract:BACKGROUND:Breast asymmetry is commonly accompanied by tuberous deformity. To date, no study has reported the incidence of this breast deformity in the presence of asymmetry. A retrospective analysis of standard preoperative photographs was performed on 375 consecutive female patients presenting for mammaplasty over a ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000189206.94466.a9

    authors: DeLuca-Pytell DM,Piazza RC,Holding JC,Snyder N,Hunsicker LM,Phillips LG

    更新日期:2005-12-01 00:00:00

  • Histologic, histochemical, and ultrastructural analysis of soft tissues from cleft and normal lips.

    abstract::The cause of cleft lip remains speculative. The nature and extent of pathophysiologic changes in cleft lip muscle are controversial. This study was undertaken to better understand the developmental processes at work. There were two groups of patients. In group 1, 40 fresh tissue specimens were taken from 22 patients w...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200109010-00002

    authors: de Chalain T,Zuker R,Ackerley C

    更新日期:2001-09-01 00:00:00

  • Effects of single-dose steroid usage on edema, ecchymosis, and intraoperative bleeding in rhinoplasty.

    abstract::To examine the effects of single-dose dexamethasone use on edema, ecchymosis, and intraoperative bleeding in rhinoplasty, a double-blind, randomized trial with placebo control was planned. A total of 55 consecutive patients were included in the study. The dexamethasone (10 mg) was given intravenously just before surge...

    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00006534-199912000-00041

    authors: Kara CO,Gökalan I

    更新日期:1999-12-01 00:00:00

  • Benign and premalignant skin lesions.

    abstract:LEARNING OBJECTIVES:After reading this article, the participant should be able to: 1. Clinically describe various cutaneous neoplasms. 2. Identify the corresponding histopathologic findings. 3. Discuss the optimal treatment approach for each entity. SUMMARY:Cutaneous neoplasms are broadly viewed as benign, premalignan...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0b013e3181d6e89a

    authors: Lee EH,Nehal KS,Disa JJ

    更新日期:2010-05-01 00:00:00

  • Living Donation of Vascularized Composite Allografts.

    abstract::Living donation has become a medically and ethically accepted practice in solid organ transplantation. Published proceedings from the international kidney transplant community and from the Ethics Committee of The Transplantation Society articulated the general principles and specific recommendations for living donatio...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000004659

    authors: Pomahac B,Alhefzi M,Bueno EM,McDiarmid SV,Levin LS

    更新日期:2018-09-01 00:00:00

  • Holoprosencephaly and midline facial anomalies: redefining classification and management.

    abstract::Holoprosencephaly encompasses a series of midline defects of the brain and face. Most cases are associated with severe malformations of the brain which are incompatible with life. At the other end of the spectrum, however, are patients with midline facial defects and normal or near-normal brain development. Although s...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199212000-00002

    authors: Elias DL,Kawamoto HK Jr,Wilson LF

    更新日期:1992-12-01 00:00:00

  • Quadrilateral space syndrome: diagnosis and operative decompression technique.

    abstract::We present a series of five patients with quadrilateral space syndrome. All patients had the diagnosis made on the basis of (1) tenderness over the quadrilateral space, (2) paresthesia over the lateral shoulder and upper posterior arm, and (3) deltoid weakness associated with decreased shoulder abduction. A history of...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199105000-00016

    authors: Francel TJ,Dellon AL,Campbell JN

    更新日期:1991-05-01 00:00:00

  • The operative treatment of isolated craniofacial dysostosis (plagiocephaly): a comparison of the unilateral and bilateral techniques.

    abstract::Both the safety and efficacy of the treatment of isolated craniofacial dysostosis (plagiocephaly) in infancy have been demonstrated. Opinions remain divided, however, as to the optimal type of procedure to be undertaken. In an attempt to answer this question, we have retrospectively evaluated a study population of 48 ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199005000-00003

    authors: Bartlett SP,Whitaker LA,Marchac D

    更新日期:1990-05-01 00:00:00

  • One versus Two Venous Anastomoses in Anterolateral Thigh Flap Reconstruction after Oral Cancer Ablation.

    abstract:BACKGROUND:Whether one-vein or two-vein drainage yields better outcomes in anterolateral thigh flap reconstruction after oral cancer ablation is still being debated. Thus, the authors investigated this question. METHODS:In this retrospective cohort study, the authors reviewed the charts of 321 patients with oral cance...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000002365

    authors: Lee YC,Chen WC,Chen SH,Hung KS,Hsiao JR,Lee JW,Shieh SJ

    更新日期:2016-08-01 00:00:00

  • A comparison of scar revision with the free electron and carbon dioxide resurfacing lasers.

    abstract::Laser scar revision was studied to measure the effects of targeting extracellular matrix protein versus tissue water on scar revision. We compared the free electron laser used at 7.7 microm (the amide III protein absorption band) to the carbon dioxide (CO2) laser and dermabrasion.Nude mice (n = 40) that had rejected s...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200110000-00026

    authors: Chen JS,Shack RB,Reinisch L,Spector N,Zinsser JW,Weisberg NK,Stricklin GP,Ellis DL

    更新日期:2001-10-01 00:00:00

  • Cadaveric Study of a Z-Plasty Modification to the Moberg Flap for Increased Advancement and Decreased Morbidity.

    abstract:BACKGROUND:The Moberg advancement flap is a well-established tool to provide sensate, vascularized tissue for thumb reconstruction. Modifications providing additional length have been described, but no studies have examined how much additional advancement can be achieved consistently, and at what cost. The authors hypo...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000479988.80490.b8

    authors: Jindal R,Schultz BE,Ruane EJ,Spiess AM

    更新日期:2016-03-01 00:00:00

  • The effect of unilateral partial facial paralysis on nasofrontal sutural growth: an experimental study in the rabbit.

    abstract::In a previous study in the rabbit, it was demonstrated that paralysis of the midfacial musculature results in decreased anteroposterior growth of the snout. At the end of growth, these animals showed macroscopically striking similarities to animals with unilateral fusion of the nasofrontal suture. In this study, wheth...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199906000-00013

    authors: Sinsel NK,Guelinckx PJ,Opdebeeck H

    更新日期:1999-06-01 00:00:00

  • Computerized tomography and B-scan ultrasonography in the diagnosis of fractures of the medial orbital wall.

    abstract::Ultrasound and CT scans have been used to examine 12 patients with suspected medial orbital wall fractures. A good correlation between ultrasound and CT scanning was demonstrated, and the authors believe that either investigation is a suitable alternative to conventional radiology when this type of injury is suspected...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198103000-00001

    authors: Ord RA,Le May M,Duncan JG,Moos KF

    更新日期:1981-03-01 00:00:00

  • Long-term histopathologic evaluation of human expanded skin.

    abstract::Forty-two patients operated on by skin expansion have been contacted after a mean time of 25 months from the last surgery. Two biopsies have been taken from the expanded area of each patient. In 12 patients it has been possible to obtain a similar sampling from the opposite, nonexpanded area of the body. The samples u...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199210000-00013

    authors: Matturri L,Azzolini A,Riberti C,Lavezzi AM,Cavalca D,Vercesi F,Azzolini C

    更新日期:1992-10-01 00:00:00

  • Surgical treatment of periocular hemangiomas: a single-center experience.

    abstract:BACKGROUND:At Great Ormond Street Hospital for Children, patients with periocular hemangiomas are assessed in a multidisciplinary team setting using a protocol developed in 1999. As part of this protocol, surgery is indicated for lesions that continue to cause amblyopia despite treatment with systemic or intralesional ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000256068.52183.f5

    authors: Geh JLC,Geh VSY,Jemec B,Liasis A,Harper J,Nischal KK,Dunaway D

    更新日期:2007-04-15 00:00:00

  • The effect of muscle transplantation after unilateral partial facial paralysis on craniofacial growth and development: relationship between muscle and nerve histomorphometric findings.

    abstract::Muscle transplantation has become an indispensable tool to restore the smile in patients with long-standing or congenital facial paralysis. However, little is known of the effect of this surgical intervention on craniofacial growth and development or of the adaptation of the transplant to its recipient site under circ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200001000-00020

    authors: Sinsel NK,Guelinckx PJ,Opdebeeck H

    更新日期:2000-01-01 00:00:00

  • Diced cartilage grafts in rhinoplasty surgery.

    abstract::The use of diced cartilage grafts in rhinoplasty surgery was recently revived by Erol with the publication of his technique for "Turkish delight" grafts (i.e., diced cartilage grafts wrapped in Surgicel). The present study details the authors' experience with 50 consecutive diced cartilage grafts used in three configu...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000122544.87086.b9

    authors: Daniel RK,Calvert JW

    更新日期:2004-06-01 00:00:00