Abstract:
:Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance. Recently, epigenetic mechanisms have been involved in the pathogenesis of PCOS. Several studies showed that methylation in DNA and miRNAs is altered in women with PCOS in blood, serum, adipose tissue, granulose cells and theca. This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauterine environment or by postnatal environmental elements such as diet and or obesity.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Concha C F,Sir P T,Recabarren SE,Pérez B Fdoi
10.4067/s0034-98872017000700907subject
Has Abstractpub_date
2017-07-01 00:00:00pages
907-915issue
7eissn
0034-9887issn
0717-6163pii
S0034-98872017000700907journal_volume
145pub_type
杂志文章,评审abstract::Background The treatment of choice of newly diagnosed multiple myeloma (NDMM) is an induction with proteasome inhibitors followed autologous stem cell transplantation (HSCT). Since 2013, the treatment of these patients in the public system is based on CTD (cyclophosphamide, thalidomide, and dexamethasone). Aim To eval...
journal_title:Revista medica de Chile
pub_type: 杂志文章,多中心研究
doi:10.4067/S0034-98872019001201561
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:In 1992, a consensus conference defined the terms systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and septic shock. Since then, numerous reports have validated the prognostic usefulness of these operative definitions. AIM:To evaluate if sepsis severity criteria, as defined by the Conse...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract::Papillary serous carcinoma with low malignant potential, similar to those described in the ovary, can also originate in the peritoneum. Characteristically they show peritoneal spread without involvement of the ovary and, if present, it corresponds to a superficial implant similar to those seen in the rest of the perit...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::Myocardial bridging of the epicardic coronary arteries is not an uncommon finding in angiographic or necropsic studies. Patients who have symptoms usually improve with medical treatment. However, in refractory patients a surgical myotomy of overlying myocardium and/or a coronary bypass may be needed. We report two pat...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::The september 1888 issue of the Journal contains an article by Luis Asta-Buruaga MD, "Ambulances in New York: a system to be instituted in Santiago. In addition to encouraging this project, the idea of establishing small hospitals in peripheral quarters of the city is discussed. Dr Asta-Buruaga was a graduate from Col...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::This article explores the causes of the crisis in the role of internists. As in the United States, the progressive specialization of internists lead to a dehumanized, expensive and technical practice of medicine. Aiming to better incomes and prestige, more than 60% of internists practice as specialists. Primary care p...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association. AIM:To investigate the association of TCF7L2 (rs7903146) genotype...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000800965
更新日期:2019-08-01 00:00:00
abstract::In 160 girls from low and middle socio-economic class of Santiago we correlated the age at menarque with genetic markers such as ABO blood group, Rh, MN, Xg, haptoglobins, Esterase D and Phosphoglucomutase. No significant association of these markers and age at menarque was found. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Struma ovarii is a teratoma composed of thyroid tissue and can be a rare cause of hyperthyroidism. We report a 35 years old woman with a left ovarian mass whose pathology revealed a Struma ovarii. This tumor was partially excised initially to avoid fertility problems and after a successful gestation, the tumor was com...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Skin prick test (SPT) of immediate hypersensitivity is a main instrument in the diagnosis of allergy. AIM:To demonstrate the applicability of skin prick test in different age groups. PATIENTS AND METHODS:We studied children and adolescents with the diagnosis of allergy in the Pediatric Respiratory Laborato...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005000200007
更新日期:2005-02-01 00:00:00
abstract::Obstructive Sleep Apnea (OSA) is characterized by repetitive upper airway collapse with apnea/hypopnea and recurrent hypoxia during sleep, which results in fragmented sleep and intermittent drops in arterial blood oxygen saturation (hypoxemia). Several dysfunctions of neurocognitive, endocrine, cardiovascular, and met...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872014000600009
更新日期:2014-06-01 00:00:00
abstract::Although the use of cadaveric split or living donor liver transplantation is a valid option for liver transplants, they have several complications, being the "small-for-size syndrome" one of the most frequent. This entity is mainly due to the incapacity that the graft has to meet the blood drainage demands. We report ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000700009
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Chile, a middle-income country with an HIV epidemic of moderate proportions (global infection rate 0.2%) began a government sponsored, free, highly active antiretroviral therapy (HAART) for patients from the public health system in 2001 reaching in 2004 a 100% coverage. Arriaran Foundation (AF) is the larges...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000500006
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Respiratory pathogens are becoming increasingly resistant to antimicrobials. A new group of drugs, called respiratory quinolones have been synthesized to overcome this problem. AIM:To study the in vitro susceptibility of respiratory pathogens to old and new antimicrobials. MATERIALS AND METHODS:Forty five ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Secondhand smoke (SHS) is an established cause of morbidity and mortality among non-smokers. The workplace is an important source of exposure, especially among workers of restaurants, bars and nightclubs. AIM:To estimate the daily occupational exposure to SHS among non-smoking workers of bars and restaurant...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010001300007
更新日期:2010-12-01 00:00:00
abstract::We report a 70 years old man presenting with malaise, anal pain and progressive defecation difficulty, with a decrease in stool caliber. The patient had no contact or past history of tuberculosis. On physical examination, there was an ulcerated anal lesion with purulent discharge, that produced an anal stenosis. The p...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::Antibacterial potency of cephalosporins depends on inhibition (acylation) of one or more penicillin-binding proteins (PBP). Recently, reduced affinity of PBP for cephalosporins and other B-lactam agents has been found in some cases. Mechanism for these changes in affinity are analyzed in this review. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:It is not clear if old age is a risk factor for adverse drug reactions. AIM:To study the incidence of adverse drug reactions and the effect of age in patients admitted to an Internal Medicine Service in an university hospital. PATIENTS AND METHODS:Two hundred one patients, hospitalized at the Clinical Hosp...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::In the last years our country has been affected by several outbreaks of infectious diseases such as Cholera and Hanta virus and recently, by pathogens associated to red tide. Chile was able to manage those emergencies using the local health system. The new threat that may emerge and could eventually overcome that capa...
journal_title:Revista medica de Chile
pub_type: 社论
doi:10.4067/s0034-98872005000900001
更新日期:2005-09-01 00:00:00
abstract::We report a 58-year-old female presenting with fever and vomiting. The initial laboratory examination disclosed two blood cultures that were positive for Streptococcus Pyogenes. An abdominal CAT scan showed a right basal pneumonia. The patient was treated with antimicrobials and discharged with oral cefadroxil for 21 ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872010000700009
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:The Chilean Ministry of Health proposed the use of "Mini Nutritional Assessment", to identify elders at nutritional risk. This score considers anthropometric, dietary and quality of life items. AIM:To assess the concordance of the mini nutritional assessment with body mass index and dietary parameters in Ch...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Evaluation of 24-hour collection accuracy is based on urinary creatinine excretion (UCr), usually using wide ranges indexed by weight. Equations that predict the expected UCr are also available. AIM:To generate an equation for estimating UCr in Chilean population and evaluate its performance in comparison t...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872020000600734
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Worldwide, smoking is the main avoidable cause of death among adults. AIM:To study smoking habits among health care workers in Chile. MATERIAL AND METHODS:A national survey about smoking among subjects working in the Chilean Ministry of Health. An anonymous and self administered enquiry was used. RESULTS:...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004000200013
更新日期:2004-02-01 00:00:00
abstract::A critical situation surrounds Internal Medicine and the training of internists. The crucial role of Internal Medicine as an integrating discipline in clinical medicine and its relationship with primary care medicine and the specialties is analyzed. The goals of a training program for general internists and specialist...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::We report a 61 years old male presenting with a right cerebral infarction, along with a type I persistent left proatlantal artery (PA), which is a form of primitive carotid-basilar anastomosis. The patient had an absence of the ipsilateral vertebral artery (VA) and hypoplasia of the contralateral VA, while the basilar...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015000800018
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Attention deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurobiological disorder of childhood onset, characterized by hyperactivity, impulsiveness or inattentiveness. AIM:To search for differences in risk for ADHD and its components among Chilean native and mixed populations and to loo...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000500006
更新日期:2011-05-01 00:00:00
abstract::Chile made several legal, practical and educational changes to the organ donation and transplant system in recent years, to improve its results. However, studies evaluating these reforms and suggesting further corrections are still pending. Our aim is to assess the new regulations and their reception by both the popul...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000600780
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Aortic valve stenosis is the most prevalent valvulopathy in the elderly, but it is frequently undertreated. AIM:To assess early and long term results of valve replacement with bioprostheses in patients 70 years old or older with aortic stenosis. PATIENTS AND METHODS:A review of the database of the Cardiova...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000200002
更新日期:2011-02-01 00:00:00
abstract::A great progress in the knowledge about hepatitis virus has occurred in the last decades and several virus have been identified. Virus B, C and D are transmitted parenterally, while virus A and E use the enteral route. Highly effective vaccines for A and B hepatitis are presently available. Virus C is an important cau...
journal_title:Revista medica de Chile
pub_type: 社论,评审
doi:
更新日期:1999-10-01 00:00:00
abstract::In the last decades, there has been an increase in life expectancy in the world, with the consequent modification in the proportion of adults over 60 years. This is accompanied by an increase in pathologies for which aging is the main risk factor, such as dementia and hearing loss, which profoundly affect the quality ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872020000801128
更新日期:2020-08-01 00:00:00