Abstract:
:Therapy with interleukin-2 (IL-2) achieves reproducible objective responses in 20%-30% of patients with malignant melanoma (MM) and renal cell carcinoma (RCC). This cytokine has significant dose and schedule dependence with regard to both clinical toxicity and biological activity. This article reviews the current status of clinical trials with IL-2 used as a single agent in a variety of doses and schedules or in combination with lymphokine-activated killer (LAK) cells in RCC and MM. The article also discusses the rationale, preclinical data, and preliminary clinical trial experience with IL-2 in combination with other cytokines such as IFN-alpha, monoclonal antitumor antibodies, and tumor infiltrating lymphocytes (TILs).
journal_name
Oncol Nurs Forumjournal_title
Oncology nursing forumauthors
Parkinson DRsubject
Has Abstractpub_date
1989-11-01 00:00:00pages
16-20issue
6 Suppleissn
0190-535Xissn
1538-0688journal_volume
16pub_type
临床试验,杂志文章,评审abstract:PURPOSE/OBJECTIVES:To review the literature regarding the development of hyperglycemia associated with neoadjuvant agents used in the treatment of solid tumor cancers. DATA SOURCES:Research articles were obtained from PubMed, CINAHL®, and Cochrane Reviews. The following search terms were used alone and in combination:...
journal_title:Oncology nursing forum
pub_type: 杂志文章,评审
doi:10.1188/14.ONF.E343-E354
更新日期:2014-11-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To examine the impact of advanced practice nurse (APN)-administered low-level laser therapy (LLLT) as both a stand-alone and complementary treatment for arm volume, symptoms, and quality of life (QOL) in women with breast cancer-related lymphedema. DESIGN:A three-group, pilot, randomized clinical tr...
journal_title:Oncology nursing forum
pub_type: 杂志文章,随机对照试验
doi:10.1188/13.ONF.383-393
更新日期:2013-07-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To review the diseases of childhood for which bone marrow transplantation (BMT) is an accepted treatment modality. DATA SOURCES:Book chapters, journal articles. DATA SYNTHESIS:BMT is used to treat a wide variety of nonmalignant and malignant childhood conditions. Despite treatment successes, BMT an...
journal_title:Oncology nursing forum
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To provide an overview of current issues surrounding the prevention of and screening for lung, breast, cervical, colorectal, ovarian, prostate, and skin cancer. DATA SOURCES:Original research, review articles, and published guidelines. DATA SYNTHESIS:Although morbidity and mortality rates have decr...
journal_title:Oncology nursing forum
pub_type: 杂志文章,评审
doi:10.1188/02.ONF.853-861
更新日期:2002-06-01 00:00:00
abstract::Inappropriate and inaccurate counseling with regard to abortion and the risk of breast cancer may result if readers accept without critical review Lucille Canty's biased article on the association between induced abortion and breast cancer printed in Oncology Nursing Forum (ONF). The potential resulting psychological...
journal_title:Oncology nursing forum
pub_type: 评论,信件
doi:
更新日期:1997-11-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To determine the degree to which nurses recognize levels of depressive symptoms in their patients with cancer and to describe patient characteristics that influence the accuracy of nurses' perceptions of depressive symptoms. DESIGN:Descriptive, prospective correlational design. SETTING:25 community...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To examine the cultural beliefs and attitudes of African American prostate cancer survivors regarding the use of complementary and alternative medicine (CAM) modalities. RESEARCH APPROACH:Mixed methods with primary emphasis on a phenomenology approach. SETTING:In-person interviews in participants' ...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/07.ONF.359-364
更新日期:2007-03-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To determine whether patient navigation in a comprehensive community cancer center affects patient and staff perceptions of patient preparation for treatment, access to care, and overall satisfaction. DESIGN:Program evaluation with patient and staff surveys. SETTING:Comprehensive community cancer c...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/10.ONF.61-68
更新日期:2010-01-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To examine the relationships among pain, fatigue, insomnia, and gender while controlling for age, comorbidities, and stage of cancer in patients newly diagnosed with lung cancer within 56 days of receiving chemotherapy. DESIGN:Secondary data analysis. SETTING:Accrual from four sites: two clinical c...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/07.ONF.785-792
更新日期:2007-07-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To assess feasibility of using electronic health records for profiling multiple cardiovascular disease (CVD) risk factors in women with breast cancer at diagnosis and five years post-treatment, and to explore relationships among CVD risk factors and breast cancer outcomes . DESIGN:Retrospective, des...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/15.ONF.E330-E338
更新日期:2015-09-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To explore the influence of lung cancer diagnosis on interpersonal dynamics in families in which one or more members continue to smoke following diagnosis. RESEARCH APPROACH:Descriptive, qualitative. SETTING:Three cancer care sites in western Canada. PARTICIPANTS:16 participants from 8 family dyad...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/09.ONF.E126-E132
更新日期:2009-05-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To review clinical applications and nursing care activities for patients receiving cladribine, a synthetic antineoplastic agent used to treat lymphoid malignancies. DATA SOURCES:Clinical trial data, published articles, reports from oncology nurses, and personal observations. DATA SYNTHESIS:Cladribi...
journal_title:Oncology nursing forum
pub_type: 杂志文章,评审
doi:
更新日期:1995-10-01 00:00:00
abstract:PURPOSE:To explore perspectives of hospitalized adults with cancer regarding engagement in fall prevention plans. The primary aim was to discover new knowledge about patients' perspectives and improve the design of fall prevention strategies. A secondary aim was to compare fall-related perspectives of patients who had ...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/20.ONF.457-468
更新日期:2020-07-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To compare the hot flash symptom experience and related outcomes between breast cancer survivors and healthy women. DESIGN:Descriptive, cross-sectional, comparative study. SETTING:Southeastern university medical center. SAMPLE:69 of 207 breast cancer survivors contacted via a tumor registry and 63...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/02.ONF.E16-E25
更新日期:2002-04-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To evaluate the relationship between nausea and exercise during and after adjuvant cancer treatment (chemotherapy and radiation therapy or chemotherapy alone). DESIGN:Secondary data analysis from a longitudinal, single-blinded, three-arm, randomized controlled trial. The trial failed to show a signi...
journal_title:Oncology nursing forum
pub_type: 杂志文章,随机对照试验
doi:10.1188/08.ONF.830-835
更新日期:2008-09-01 00:00:00
abstract::Although the right to health care is not written into the U.S. Constitution, moral and ethical tenets govern the delivery of optimal medical care universally and across the life continuum. Pertaining to children, in accordance with the Geneva Declaration of the Rights of the Child of 1924 and the United Nations Human ...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/16.ONF.281-283
更新日期:2016-05-01 00:00:00
abstract::Think back to the day you graduated from your entry-level nursing program. The feelings we experienced at that time are likely universal, whether that day was one year ago or more than 40 years ago. No more tests, no more papers, no more clinical skills practice, and no more preparing the dreaded nursing care plan. Sc...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/13.ONF.537-539
更新日期:2013-11-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To evaluate the outcomes of hospice services and explore factors that affect the quality of life (QOL) of patients with cancer receiving hospice care. DESIGN:Descriptive. SETTING:Two homecare hospices in the southeastern United States. SAMPLE:Convenience sample of 118 hospice patients with a diagn...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::Flow cytometry is a method of rapidly analyzing large numbers of cells as they flow in a liquid medium through a laser source. Flow cytometry provides valuable information regarding DNA content, RNA content, and the percentage of cells in the S phase of the cell cycle. This information can be used to predict the aggre...
journal_title:Oncology nursing forum
pub_type: 杂志文章,评审
doi:
更新日期:1992-04-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To provide a review of glial neoplasms including histologic classification, signs and symptoms, diagnostic evaluation, treatment options, and nursing care. DATA SOURCES:Articles, books, proceedings of national meetings. DATA SYNTHESIS:Glial neoplasms vary according to prognosis and treatment option...
journal_title:Oncology nursing forum
pub_type: 杂志文章,评审
doi:
更新日期:1996-05-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To examine melanoma-related knowledge, sun exposure, and sun protection to determine whether increased awareness is associated with a reduction in risk. DESIGN:Quantitative/empiricist study conducted by purpose- designed mailed questionnaire. PARTICIPANTS:Consultant oncologists at one teaching hosp...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/04.onf.641-646
更新日期:2004-05-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To measure and compare oncology clinical nurse specialists' (OCNSs) perceptions of patient outcomes influenced through their practice and barriers to outcome production. DESIGN:Descriptive survey. SETTING:National. SAMPLE:104 members of the Oncology Nursing Society Clinical Nurse Specialist Specia...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To describe school-age children's and adolescents' adjustment to parental cancer. DESIGN:Retrospective population control. SETTING:Screening cancer registries identified subjects at four Midwestern hospitals, including urban and rural settings of community and tertiary hospitals. All families were ...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To review current research examining the effects of behavioral interventions on reducing symptom distress and improving quality of life in patients with cancer and to explore the application of behavioral interventions to patients with leukemia who are immunosuppressed by the disease or its treatment...
journal_title:Oncology nursing forum
pub_type: 杂志文章,评审
doi:
更新日期:1996-04-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To describe processes for fostering community engagement among Haitian women to facilitate breast health education and outreach that are consonant with Haitians' cultural values, literacy, and linguistic skills. DATA SOURCES:Existing breast cancer education and outreach efforts for Haitian immigrant...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/09.ONF.716-722
更新日期:2009-11-01 00:00:00
abstract::The primary goal of the thousands of registered trials in cancer research is to extend survival. With evaluation of efficacy, safety, and tolerability, healthcare providers must ensure that the principles described in the Belmont Report are upheld and that patients are truly informed when signing a consent form. In th...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/16.ONF.694-696
更新日期:2016-11-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To examine the differences among secular, traditional, and religious Israeli oncology nurses' intrinsic religiosity, extrinsic religiosity, spiritual well-being, and attitudes toward spiritual care. DESIGN:A comparative, descriptive study. SAMPLE:148 Israeli Jewish nurses drawn from the membership ...
journal_title:Oncology nursing forum
pub_type: 杂志文章
doi:10.1188/04.ONF.1179-1183
更新日期:2004-11-16 00:00:00
abstract:PURPOSE/OBJECTIVES:To identify antecedents and consequences of social disconnection in African American women diagnosed with breast cancer as described in the extant literature. DATA SOURCES:Literature review using broad exploration of a personal database and informal exploration of databases such as MEDLINE®, as well...
journal_title:Oncology nursing forum
pub_type: 杂志文章,评审
doi:10.1188/14.ONF.E28-E34
更新日期:2014-01-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To evaluate the effectiveness of ondansetron for the prevention of nausea and vomiting from dimethylsulfoxide (DMSO) during autologous stem cell transplantation (ASCT) infusion. DESIGN:Nonrandomized cohort using historical control. SETTING:Comprehensive cancer center outpatient infusion department....
journal_title:Oncology nursing forum
pub_type: 临床试验,杂志文章
doi:10.1188/13.ONF.285-292
更新日期:2013-05-01 00:00:00
abstract:PURPOSE/OBJECTIVES:To make recommendations for the use of informational strategies and the development of resources for family caregivers of patients receiving marrow transplantation based on their identified informational needs. DATA SOURCES:Literature review and research that identifies informational needs of family...
journal_title:Oncology nursing forum
pub_type: 杂志文章,评审
doi:
更新日期:1996-10-01 00:00:00