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Obesity: Pathophysiology and Management.

Abstract：

:Obesity continues to be among the top health concerns across the globe. Despite our failure to contain the high prevalence of obesity, we now have a better understanding of its pathophysiology, and how excess adiposity leads to type 2 diabetes, hypertension, and cardiovascular disease. Lifestyle modification is recommended as the cornerstone of obesity management, but many patients do not achieve long-lasting benefits due to difficulty with adherence as well as physiological and neurohormonal adaptation of the body in response to weight loss. Fortunately, 5 drug therapies-orlistat, lorcaserin, liraglutide, phentermine/topiramate, and naltrexone/bupropion-are available for long-term weight management. Additionally, several medical devices are available for short-term and long-term use. Bariatric surgery yields substantial and sustained weight loss with resolution of type 2 diabetes, although due to the high cost and a small risk of serious complications, it is generally recommended for patients with severe obesity. Benefit-to-risk balance should guide treatment decisions.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Gadde KM,Martin CK,Berthoud HR,Heymsfield SB

doi

10.1016/j.jacc.2017.11.011

subject

Has Abstract

pub_date

2018-01-02 00:00:00

pages

69-84

issue

1

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(17)41584-1

journal_volume

71

pub_type

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