Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient.

Abstract:

:WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient's lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient.

journal_name

Emerg Infect Dis

authors

Siebrasse EA,Nguyen NL,Willby MJ,Erdman DD,Menegus MA,Wang D

doi

10.3201/eid2201.151384

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

24-31

issue

1

eissn

1080-6040

issn

1080-6059

journal_volume

22

pub_type

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