Targeted Therapy and Immunotherapy in the Treatment of Non-Small Cell Lung Cancer.

Abstract:

:The treatment strategy in advanced non-small cell lung cancer (NSCLC) has evolved from empirical chemotherapy to a personalized approach based on histology and molecular markers of primary tumors. Targeted therapies are directed at the products of oncogenic driver mutations. Immunotherapy facilitates the recognition of cancer as foreign by the host immune system, stimulates the immune system, and alleviates the inhibition that allows the growth and spread of cancer cells. The authors describes the role of targeted therapy and immunotherapy in the treatment of NSCLC, patterns of disease present on imaging studies, and immune-related adverse events encountered with immunotherapy.

journal_name

Radiol Clin North Am

authors

Shroff GS,de Groot PM,Papadimitrakopoulou VA,Truong MT,Carter BW

doi

10.1016/j.rcl.2018.01.012

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

485-495

issue

3

eissn

0033-8389

issn

1557-8275

pii

S0033-8389(18)30012-5

journal_volume

56

pub_type

杂志文章,评审
  • BI-RADS update.

    abstract::The updated American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) has been newly released. This article summarizes the changes and updates that have been made to BI-RADS. The goal of the revised edition continues to be the same: to improve clarification in image interpretation, maintai...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2014.02.008

    authors: Mercado CL

    更新日期:2014-05-01 00:00:00

  • Transrectal sonography in prostate evaluation.

    abstract::Prostate cancer is the most prevalent newly diagnosed noncutaneous malignancy in men. With the continued use of prostate-specific antigen screening, there has been a dramatic rise in the number of prostate biopsied performed. Transrectal ultrasonography (TRUS) is an essential tool used for detecting prostate pathology...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2006.07.001

    authors: Boczko J,Messing E,Dogra V

    更新日期:2006-09-01 00:00:00

  • Obstetric (nonfetal) complications.

    abstract::Pregnancy predisposes women to a wide array of obstetric and gynecological complications which are often complex, challenging and sometimes life-threatening. While some of these are unique to pregnancy, a few that occur in nonpregnant women are more common during pregnancy. Imaging plays a crucial role in the diagnosi...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2013.07.012

    authors: Shanbhogue AK,Menias CO,Lalwani N,Lall C,Khandelwal A,Nagar A

    更新日期:2013-11-01 00:00:00

  • Leukemia and lymphoma in childhood.

    abstract::The leukemias and lymphomas together account for over 40% of the malignant disorders in childhood. Radiologists who deal with these patients must understand some aspects of the biology, natural history, and clinical manifestations of the disease in order to provide useful imaging consultative services. This article su...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Parker BR

    更新日期:1997-11-01 00:00:00

  • MR techniques for renal imaging.

    abstract::This article describes the principles, attributes, and pitfalls of the many MR imaging approaches available for assessment of renal-related disorders. Tables 1 and 2 summarize the specific approach and rationale. ...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0033-8389(03)00069-1

    authors: Zhang J,Pedrosa I,Rofsky NM

    更新日期:2003-09-01 00:00:00

  • Osteoporosis.

    abstract::Osteoporosis, a condition of decreased bone tissue that increases the likelihood of fracture, places a significant burden on our society in terms of health cost and morbidity. The most common type of osteoporosis is involutional, and two subtypes are recognized: type 1 and type 2. Type 1, or postmenopausal, osteoporos...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Gillespy T 3rd,Gillespy MP

    更新日期:1991-01-01 00:00:00

  • Adenocarcinoma of the pancreas: CT imaging.

    abstract::CT currently plays a vital role in pancreatic cancer staging. Continued advancements in computers, scanner technology, and 3D software have improved CT detection of smaller masses and staging. In particular, the introduction of MDCT and real-time 3D volume-rendering software have greatly improved the visualization of ...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0033-8389(02)00041-6

    authors: Horton KM,Fishman EK

    更新日期:2002-12-01 00:00:00

  • Urethral disease and interventional cystourethrography.

    abstract::The innovation of balloon dilatation of urethral stricture and prostatic hypertrophy is a major contribution to interventional radiology. The procedure involves minimal trauma, produces immediate relief of symptoms, and probably results in less frequent and less difficult redilatations. The sparsity of reports in the ...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章

    doi:

    authors: McCallum RW

    更新日期:1986-12-01 00:00:00

  • Cross-sectional evaluation of thoracic lymphoma.

    abstract::In patients who have lymphoma, the presence and distribution of thoracic involvement is important in both tumor staging and treatment. Thoracic involvement in Hodgkin lymphoma (HL) is more common than in non-Hodgkin lymphoma (NHL). In HL, mediastinal lymphadenopathy with contiguous spread is a hallmark, and lung paren...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2008.03.006

    authors: Bae YA,Lee KS

    更新日期:2008-03-01 00:00:00

  • Posttherapy imaging of musculoskeletal neoplasms.

    abstract::Posttreatment imaging is important to ensure early detection of oncological complications, and appropriate timing and frequency is an important consideration, especially in high-risk patients. Focused magnetic resonance (MR) imaging is the preferred modality for detection of local recurrence of soft tissue tumors and ...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2011.07.011

    authors: Garner HW,Kransdorf MJ,Peterson JJ

    更新日期:2011-11-01 00:00:00

  • The vomiting infant: recent advances and unsettled issues in imaging.

    abstract::The evaluation of infantile vomiting is bound up with many unresolved questions and continually evolving imaging technologies. This article addresses three specific areas of interest: the use of newer low-osmolality, water-soluble contrast media in the infant's gastrointestinal tract; the ever-controversial subject of...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Bowen A

    更新日期:1988-03-01 00:00:00

  • Magnetic resonance enterography.

    abstract::Magnetic resonance (MR) enterography is a targeted examination of the gastrointestinal tract, particularly the small intestine, without nasojejunal intubation (in which case it is referred to as MR enteroclysis). Until recently, MR imaging of the small bowel could not reliably compete with the high-quality small bowel...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2012.09.007

    authors: Grand DJ,Beland M,Harris A

    更新日期:2013-01-01 00:00:00

  • Trauma to the foot.

    abstract::Minor trauma to the foot may cause stress fracture, avulsion fracture or ligamentous and tendon injury. Plain radiographs are frequently normal. Radionuclide bone scan is a sensitive detector of early bone injury. A stress fracture may develop focal uptake or diffuse uptake throughout the bone involved. MR imaging is ...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Forrester DM,Kerr R

    更新日期:1990-03-01 00:00:00

  • Neonatal cranial ultrasound.

    abstract::Neonatal cranial ultrasound continues to be a popular initial imaging modality because of the safety, low-cost, and portability of the examination. The higher frequency transducers and enhanced ability for signal processing that is possible with current ultrasound machines improves visualization of complex congenital ...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0033-8389(05)70253-0

    authors: Barr LL

    更新日期:1999-11-01 00:00:00

  • High- versus low-field MR imaging.

    abstract::The role of MR imaging as a noninvasive technique in the detection and evaluation of musculoskeletal diseases is unquestionable. Most of the studies reported in the literature are based on high-field MR imaging. Initial studies performed with low-field-strength have reported unsatisfactory results in the assessment of...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2005.02.001

    authors: Tavernier T,Cotten A

    更新日期:2005-07-01 00:00:00

  • Imaging of the Posterior Skull Base.

    abstract::The posterior skull base can be involved by a variety of pathologic processes. They can be broadly classified as: traumatic, neoplastic, vascular, and inflammatory. Pathology in the posterior skull base usually involves the lower cranial nerves, either as a source of pathology or a secondary source of symptoms. This r...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2016.08.002

    authors: Job J,Branstetter BF 4th

    更新日期:2017-01-01 00:00:00

  • Beyond the Spinal Canal.

    abstract::Cross-sectional spinal imaging is common, and extraspinal findings are often incidentally identified during interpretation. Although some of these findings may cause symptoms that mimic a spinal disorder, the majority are entirely asymptomatic and incidental. It is essential that the radiologist not only identify thos...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2018.09.009

    authors: Raghavan P,Record J,Vidal L

    更新日期:2019-03-01 00:00:00

  • Inherited cystic diseases of the kidney.

    abstract::The inherited cystic diseases of the kidney represent a diverse group of diseases. Recent advantages in molecular medicine have greatly enhanced the presymptomatic detection of these entities. To data, however, genetic tests cannot determine the severity of the disease or prevent complications. Therefore, imaging will...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Choyke PL

    更新日期:1996-09-01 00:00:00

  • Acute lung infections in normal and immunocompromised hosts.

    abstract::Pulmonary infections are among the most common causes of morbidity and mortality worldwide, and contribute substantially to annual medical expenditures in the United States. Despite the availability of antimicrobial agents, pneumonia constitutes the sixth most common cause of death and the number one cause of death fr...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2005.10.009

    authors: Waite S,Jeudy J,White CS

    更新日期:2006-03-01 00:00:00

  • Nodule characterization: subsolid nodules.

    abstract::In this review, we focus on the radiologic, clinical, and pathologic aspects primarily of solitary subsolid pulmonary nodules. Particular emphasis will be placed on the pathologic classification and correlative computed tomography (CT) features of adenocarcinoma of the lung. The capabilities of fluorodeoxyglucose posi...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章

    doi:10.1016/j.rcl.2013.08.011

    authors: Raad RA,Suh J,Harari S,Naidich DP,Shiau M,Ko JP

    更新日期:2014-01-01 00:00:00

  • Imaging of Radiation- and Medication-Related Osteonecrosis.

    abstract::Osteonecrosis is the devitalization of bone and consequent lytic changes. In the jaws, osteonecrosis is a pathologic consequence of prior radiation therapy (osteoradionecrosis) or certain antiresorptive medications. Herein, we review the pathogenesis and clinical manifestations of these lesions, and describe the spect...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2017.08.006

    authors: Mallya SM,Tetradis S

    更新日期:2018-01-01 00:00:00

  • Three-dimensional ultrasound in obstetrics and gynecology.

    abstract::Three-dimensional ultrasound is a new modality finding its way into clinical practice. Most of the major ultrasound vendors are now developing three-dimensional ultrasound capabilities. We expect that although three-dimensional ultrasound will not replace two-dimensional ultrasound, many additional benefits will be id...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0033-8389(05)70294-3

    authors: Pretorius DH,Borok NN,Coffler MS,Nelson TR

    更新日期:2001-05-01 00:00:00

  • Roentgen signs of emergent spines.

    abstract::A variety of disease processes may involve the axial skeleton, producing acute symptoms and signs. This discussion summarizes some of the important diseases that become apparent in this fashion. Roentgen manifestations of these disorders include abnormalities of vertebral body shap or density, loss of intervertebral d...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章

    doi:

    authors: Resnick D

    更新日期:1978-04-01 00:00:00

  • Fundamentals of multichannel CT.

    abstract::Multichannel CT has become a very valuable tool in diagnostic imaging. It provides a combination of fast and long coverage in conjunction with thin slices. The fast scanning allows for single-breathhold scanning, fewer motion artifacts, and better use of intravenous contrast media. The brains of the MCCT scanners are ...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0033-8389(03)00029-0

    authors: Rydberg J,Liang Y,Teague SD

    更新日期:2003-05-01 00:00:00

  • Diagnosis of recurrent and metastatic disease using f-18 fluorodeoxyglucose-positron emission tomography in breast cancer.

    abstract::One of the major strengths of F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) in breast cancer imaging is in the evaluation of patients who have suspected loco-regional recurrence or distant metastasis. In general, FDG-PET is more sensitive than conventional imaging for the detection of recurrent diseas...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2007.05.005

    authors: Eubank WB

    更新日期:2007-07-01 00:00:00

  • MR imaging of shoulder impingement and rotator cuff disease.

    abstract::A number of imaging modalities, such as conventional radiography, arthrography, ultrasonography, and MR imaging, can be used in the evaluation of shoulder pain related to impingement, tendinosis, and rotator cuff tear. Of these techniques, only MR imaging provides anatomic information coupled with superior soft-tissue...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Uri DS

    更新日期:1997-01-01 00:00:00

  • Mammography screening and the controversy concerning women aged 40 to 49.

    abstract::The screening controversy arose from inappropriate and scientifically insupportable data analysis of the early results from the randomized, controlled trials of screening. Data were used that were inadequate for making medical recommendations by using subgroup analyses from trials that were not designed to permit subg...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Kopans DB

    更新日期:1995-11-01 00:00:00

  • An introduction to economic issues in breast imaging.

    abstract::Marked increases in national health care costs, along with governmental coverage of health care costs for the elderly under Medicare, have resulted in increased government regulation of medical reimbursement rates. Private insurers and HMOs now provide reimbursements that are frequently the same or lower than those fr...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0033-8389(05)70203-7

    authors: Farria D,Feig SA

    更新日期:2000-07-01 00:00:00

  • Imaging in Osteoarthritis.

    abstract::With technologic advances and the availability of sophisticated computer software and analytical strategies, imaging plays an increasingly important role in understanding the disease process of osteoarthritis (OA). Radiography has limitations in that it can visualize only limited features of OA, such as osteophytes an...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2017.04.012

    authors: Hayashi D,Roemer FW,Jarraya M,Guermazi A

    更新日期:2017-09-01 00:00:00

  • Investigation of thyroid, head, and neck cancers with PET.

    abstract::PET with [(18)F]-fluorodeoxyglucose (FDG) has been accepted as a useful imaging modality for the diagnosis of a variety of malignancies. This article discusses the use of FDG-PET in the management of patients with thyroid and head or neck cancers. ...

    journal_title:Radiologic clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.rcl.2004.07.006

    authors: Zhuang H,Kumar R,Mandel S,Alavi A

    更新日期:2004-11-01 00:00:00