Circular RNA circSVIL Promotes Myoblast Proliferation and Differentiation by Sponging miR-203 in Chicken.

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can occur relatively early or later in life. It is well known that genetic components, such as the amyloid precursor protein gene on chromosome 21, are fundamental in early-onset AD (EOAD). To date, however, only...

journal_title：Frontiers in genetics

authors： Bajic VP,Essack M,Zivkovic L,Stewart A,Zafirovic S,Bajic VB,Gojobori T,Isenovic E,Spremo-Potparevic B

更新日期：2020-01-28 00:00:00

abstract：:Our ability to overcome the challenges behind metabolic disorders will require a detailed understanding of the regulation of responses to nutrition. The Creb3 transcription factor family appears to have a unique regulatory role that links cellular secretory capacity with development, nutritional state, infection, and ...

journal_title：Frontiers in genetics

authors： Khan HA,Margulies CE

更新日期：2019-06-21 00:00:00

abstract：:Previous efforts to characterize conservation between the human and mouse genomes focused largely on sequence comparisons. These studies are inherently limited because they don't account for gene structure differences, which may exist despite genomic sequence conservation. Recent high-throughput transcriptome studies ...

journal_title：Frontiers in genetics

authors： Wood EJ,Chin-Inmanu K,Jia H,Lipovich L

更新日期：2013-09-26 00:00:00

abstract：:Glioblastoma, also called glioblastoma multiform (GBM), is the most aggressive cancer that initiates within the brain. GBM is produced in the central nervous system. Cancer cells in GBM are similar to stem cells. Several different schemes for GBM stratification exist. These schemes are based on intertumoral molecular ...

journal_title：Frontiers in genetics

authors： Zhang YH,Li Z,Zeng T,Pan X,Chen L,Liu D,Li H,Huang T,Cai YD

更新日期：2020-11-24 00:00:00

abstract：:Known as the "fifth RNA nucleotide", pseudouridine (Ψ or psi) is the first-discovered and most abundant RNA modification occurring at the Uridine site, and it plays a prominent role in a number of biological processes. Thousands of Ψ sites have been identified within different biological contexts thanks to the advance...

journal_title：Frontiers in genetics

authors： Song B,Tang Y,Wei Z,Liu G,Su J,Meng J,Chen K

更新日期：2020-03-12 00:00:00

abstract：:Different genes have their protein products localized in various subcellular compartments. The diversity in protein localization may serve as a gene characteristic, revealing gene essentiality from a subcellular perspective. To measure this diversity, we introduced a Subcellular Diversity Index (SDI) based on the Gene...

journal_title：Frontiers in genetics

authors： Jia K,Zhou Y,Cui Q

更新日期：2020-01-21 00:00:00

abstract：:The emergence of eusociality ("true sociality") in several insect lineages represents one of the most successful evolutionary adaptations in the animal kingdom in terms of species richness and global biomass. In contrast to solitary insects, eusocial insects evolved a set of unique behavioral and physiological traits ...

journal_title：Frontiers in genetics

authors： Søvik E,Bloch G,Ben-Shahar Y

更新日期：2015-05-27 00:00:00

abstract：:Taproot skin color is a crucial visual and nutritional quality trait of radish, and purple skin is most attractive to consumers. However, the genetic mechanism underlying this character is unknown. Herein, F2 segregating populations were constructed to investigate radish genomic regions with purple skin genes. Segrega...

journal_title：Frontiers in genetics

authors： Liu T,Wang J,Wu C,Zhang Y,Zhang X,Li X,Wang H,Song J,Li X

更新日期：2019-09-20 00:00:00

abstract：Background:Recent evidence has indicated that long non-coding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) to modulate mRNAs expression by sponging microRNAs (miRNAs). However, the specific mechanism and function of lncRNA-miRNA-mRNA regulatory network in non-small cell lung cancer (NSCLC) remains ...

journal_title：Frontiers in genetics

authors： Wang M,Zheng S,Li X,Ding Y,Zhang M,Lin L,Xu H,Cheng Y,Zhang X,Xu H,Li S

更新日期：2020-09-18 00:00:00

abstract：OBJECTIVE:We report the first pediatric specific Phenome-Wide Association Study (PheWAS) using electronic medical records (EMRs). Given the early success of PheWAS in adult populations, we investigated the feasibility of this approach in pediatric cohorts in which associations between a previously known genetic variant...

journal_title：Frontiers in genetics

authors： Namjou B,Marsolo K,Caroll RJ,Denny JC,Ritchie MD,Verma SS,Lingren T,Porollo A,Cobb BL,Perry C,Kottyan LC,Rothenberg ME,Thompson SD,Holm IA,Kohane IS,Harley JB

更新日期：2014-11-18 00:00:00

abstract：:For datasets of gastric cancer collected by TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) repositories, we applied a bioinformatics approach to obtain expression data for the ISLR (immunoglobulin superfamily containing leucine-rich repeat) gene, which is highly expressed in gastric cancer tissues an...

journal_title：Frontiers in genetics

authors： Li S,Zhao W,Sun M

更新日期：2020-06-16 00:00:00

abstract：:In recent years, studies have shown that phytopathogenic fungi possess the ability of cross-kingdom regulation of host plants through small RNAs (sRNAs). Magnaporthe oryzae, a causative agent of rice blast, introduces disease by penetrating the rice tissues through appressoria. However, little is known about the trans...

journal_title：Frontiers in genetics

authors： Zhang H,Liu S,Chang H,Zhan M,Qin QM,Zhang B,Li Z,Liu Y

更新日期：2019-03-29 00:00:00

abstract：:Lin28 is a developmentally regulated RNA-binding protein that plays important roles in diverse physiological and pathological processes including oncogenesis and brain synaptic function. These pleiotropic roles of Lin28 are mechanistically linked both to its ability to directly stimulate translation of genes involved ...

journal_title：Frontiers in genetics

authors： Kallen AN,Ma J,Huang Y

更新日期：2012-11-16 00:00:00

abstract：:Fragile-X syndrome is one of the most common forms of inherited mental retardation and autistic behaviors. The reduction/absence of the functional FMRP protein, coded by the X-linked Fmr1 gene in humans, is responsible for the syndrome. Patients exhibit a variety of symptoms predominantly linked to the function of FMR...

journal_title：Frontiers in genetics

authors： Specchia V,Puricella A,D'Attis S,Massari S,Giangrande A,Bozzetti MP

更新日期：2019-02-13 00:00:00

abstract：:Using genomic information, local ruminant populations can be better characterized and compared to selected ones. Genetic relationships between animals can be established even without systematic pedigree recording, provided a budget is available for genotyping. Genomic selection (GS) can rely on a subset of the total p...

journal_title：Frontiers in genetics

authors： Ducrocq V,Laloe D,Swaminathan M,Rognon X,Tixier-Boichard M,Zerjal T

更新日期：2018-07-13 00:00:00

abstract：:Diabetes mellitus represents a group of complex metabolic diseases that result in impaired glucose homeostasis, which includes destruction of β-cells or the failure of these insulin-secreting cells to compensate for increased metabolic demand. Despite a strong interest in characterizing the transcriptome of the differ...

journal_title：Frontiers in genetics

authors： Kameswaran V,Kaestner KH

更新日期：2014-07-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease for which it is difficult to find exact disease-related genes. Effectively identifying disease-related genes would contribute to improving the treatment and diagnosis of multiple sclerosis. Current methods for identifying disease-related genes mainly focus on the hypoth...

journal_title：Frontiers in genetics

authors： Liu H,Guan J,Li H,Bao Z,Wang Q,Luo X,Xue H

更新日期：2020-04-21 00:00:00

abstract：:Pathway analysis is a powerful method for data analysis in genomics, most often applied to gene expression analysis. It is also promising for single-nucleotide polymorphism (SNP) data analysis, such as genome-wide association study data, because it allows the interpretation of variants with respect to the biological p...

journal_title：Frontiers in genetics

authors： Cirillo E,Parnell LD,Evelo CT

更新日期：2017-11-07 00:00:00

abstract：:Drought alone or in combination with other stresses forms the major crop production constraint worldwide. Sorghum, one of the most important cereal crops is affected by drought alone or in combination with co-occurring stresses; notwithstanding, sorghum has evolved adaptive responses to combined stresses. Furthermore,...

journal_title：Frontiers in genetics

authors： Woldesemayat AA,Ntwasa M

更新日期：2018-11-20 00:00:00

abstract：:Cereals are a staple food for many people around the world; however, they are also a major dietary source of toxic metal(loid)s. Many agricultural regions throughout the world are contaminated with toxic metal(loid)s, which can accumulate to high levels in the grains of cereals cultivated in these regions, posing seri...

journal_title：Frontiers in genetics

authors： Deng F,Yu M,Martinoia E,Song WY

更新日期：2019-04-09 00:00:00

abstract：:Fragile X syndrome (FXS) is mostly caused by two distinct events that occur in the FMR1 gene (Xq27.3): an expansion above 200 repeats of a CGG triplet located in the 5'UTR of the gene, and methylation of the cytosines located in the CpG islands upstream of the CGG repeats. Here, we describe two unrelated families with...

journal_title：Frontiers in genetics

authors： Fernández E,Gennaro E,Pirozzi F,Baldo C,Forzano F,Turolla L,Faravelli F,Gastaldo D,Coviello D,Grasso M,Bagni C

更新日期：2018-11-02 00:00:00

abstract：:Silversides are fish that inhabit marine coastal waters, coastal lagoons, and estuarine regions in southern South America. The freshwater (FW) silversides have the ability to tolerate salinity variations. Odontesthes humensis have similar habitats and biological characteristics of congeneric O. bonariensis, the most s...

journal_title：Frontiers in genetics

authors： Silveira TLR,Martins GB,Domingues WB,Remião MH,Barreto BF,Lessa IM,Santos L,Pinhal D,Dellagostin OA,Seixas FK,Collares T,Robaldo RB,Campos VF

更新日期：2018-02-06 00:00:00

abstract：:Sorting of individual chromosomes by Flow Cytometry (flow-sorting) is an enrichment method to potentially simplify genome assembly by isolating chromosomes from the context of the genome. We have recently developed a workflow to sequence native, unamplified DNA and applied it to the smallest human chromosome, the Y ch...

journal_title：Frontiers in genetics

authors： Kuderna LFK,Solís-Moruno M,Batlle-Masó L,Julià E,Lizano E,Anglada R,Ramírez E,Bote A,Tormo M,Marquès-Bonet T,Fornas Ò,Casals F

更新日期：2020-01-09 00:00:00

abstract：:Colon cancer has the third highest incidence and mortality among cancers in the United States. MicroRNA-21 (miR21) has been described as an oncomir that is highly overexpressed in tumor tissue from colorectal cancer. Recent studies showed that silencing of miR21 through use of a miR21 inhibitor (anti-miR21) affected v...

journal_title：Frontiers in genetics

authors： Song MS,Rossi JJ

更新日期：2014-01-02 00:00:00

abstract：:Variability of the comet assay is a serious issue, whether it occurs from experiment to experiment in the same laboratory, or between different laboratories analysing identical samples. Do we have to live with high variability, just because the comet assay is a biological assay rather than analytical chemistry? Numero...

journal_title：Frontiers in genetics

authors： Collins AR,El Yamani N,Lorenzo Y,Shaposhnikov S,Brunborg G,Azqueta A

更新日期：2014-10-20 00:00:00

abstract：:Filet quality traits determine consumer satisfaction and affect profitability of the aquaculture industry. Soft flesh is a criterion for fish filet downgrades, resulting in loss of value. Filet firmness is influenced by many factors, including rate of protein turnover. A 50K transcribed gene SNP chip was used to genot...

journal_title：Frontiers in genetics

authors： Ali A,Al-Tobasei R,Lourenco D,Leeds T,Kenney B,Salem M

更新日期：2019-05-03 00:00:00

abstract：:RNA-binding proteins (RBPs) interacting with target RNAs play essential roles in RNA metabolism at the post-transcription level. Perturbations of RBPs can accelerate cancer development and cause dysregulation of the immune cell function and activity leading to evade immune destruction of cancer cells. However, few stu...

journal_title：Frontiers in genetics

authors： Hu G,Jiang Q,Liu L,Peng H,Wang Y,Li S,Tang Y,Yu J,Yang J,Liu Z

更新日期：2021-01-11 00:00:00

abstract：:In recent years, there has been an explosive increase in the amount of bioinformatics data produced, but data are not information. The purpose of bioinformatics research is to obtain information with biological significance from large amounts of data. Multiple sequence alignment is widely used in sequence homology det...

journal_title：Frontiers in genetics

authors： Shi H,Zhang X

更新日期：2020-02-27 00:00:00

abstract：:Improving grain yield in the staple food crop rice has been long sought goal of plant biotechnology. One of the traits with significant impact on rice breeding programs is peduncle elongation at the time of heading failing which leads to significant reduction in grain yield due to incomplete panicle exsertion. To deci...

journal_title：Frontiers in genetics

authors： Kandpal M,Vishwakarma C,Krishnan K,Chinnusamy V,Pareek A,Sharma MK,Sharma R

更新日期：2020-12-03 00:00:00

abstract：:Next generation sequencing (NGS) technologies, primarily based on massively parallel sequencing, have touched and radically changed almost all aspects of research worldwide. These technologies have allowed for the rapid analysis, to date, of the genomes of more than 2,000 different species. In humans, NGS has arguably...

journal_title：Frontiers in genetics

authors： Peters BA,Liu J,Drmanac R

更新日期：2015-01-14 00:00:00