Drosophila melanogaster as a Model to Study the Multiple Phenotypes, Related to Genome Stability of the Fragile-X Syndrome.

abstract：:Communication disorders have complex genetic origins, with constellations of relevant gene markers that vary across individuals. Some genetic variants are present in healthy individuals as well as those affected by developmental disorders. Growing evidence suggests that some variants may increase susceptibility to the...

journal_title：Frontiers in genetics

authors： Centanni TM,Green JR,Iuzzini-Seigel J,Bartlett CW,Hogan TP

更新日期：2015-08-24 00:00:00

abstract：:Inverted repeat (IR) regions in the plastomes from land plants induce homologous recombination, generating isomeric plastomes. While the plastomes of Taxaceae species often lose one of the IR regions, considerable isomeric plastomes were created in Taxaceae species with a hitherto unclarified mechanism. To investigate...

journal_title：Frontiers in genetics

authors： Zhang Y,Xu Y,Chen H,Wang L,Yin K,Du FK

更新日期：2020-01-14 00:00:00

abstract：:Few studies have been conducted to explore the influence of the catechol-o-methyltransferase (COMT) genotype on the severity of and treatment efficacy on auditory verbal hallucination (AVH) symptoms in healthy individuals with AVHs (Hi-AVHs). We hypothesized that the efficacy of dopamine antagonist treatment on AVHs i...

journal_title：Frontiers in genetics

authors： Zhuo C,Xu Y,Zhang L,Jing R,Zhou C

更新日期：2019-03-06 00:00:00

abstract：:Tolerance to infections is defined as the ability of a host to limit the impact of a given pathogen burden on host performance. Uncoupling resistance and tolerance is a challenge, and there is a need to be able to separate them using specific trait recording or statistical methods. We present three statistical methods...

journal_title：Frontiers in genetics

authors： Kause A,Odegård J

更新日期：2012-12-14 00:00:00

abstract：:Accurate inference of causal gene regulatory networks from gene expression data is an open bioinformatics challenge. Gene interactions are dynamical processes and consequently we can expect that the effect of any regulation action occurs after a certain temporal lag. However such lag is unknown a priori and temporal a...

journal_title：Frontiers in genetics

authors： Lopes M,Bontempi G

更新日期：2013-12-24 00:00:00

abstract：:The diagnosis of mesothelioma is not always straightforward, despite known immunohistochemical markers and other diagnostic techniques. One reason for the difficulty is that extrapleural tumors resembling mesothelioma may have several possible etiologies, especially in cases with no meaningful history of amphibole asb...

journal_title：Frontiers in genetics

authors： Kerger BD,James RC,Galbraith DA

更新日期：2014-05-30 00:00:00

abstract：:Transcription is a tightly regulated process ensuring the proper expression of numerous genes regulating all aspects of cellular behavior. Transcription factors regulate multiple genes including other transcription factors that together control a highly complex gene network. The transcriptional machinery can be "hijac...

journal_title：Frontiers in genetics

authors： Faridi F,Ponnusamy K,Quagliano-Lo Coco I,Chen-Wichmann L,Grez M,Henschler R,Wichmann C

更新日期：2013-11-28 00:00:00

abstract：:Transcriptomics technologies such as next-generation sequencing and microarray platforms provide exciting opportunities for improving diagnosis and treatment of complex diseases. Transcriptomics studies often share similar hypotheses, but are carried out on different platforms, in different conditions, and with differ...

journal_title：Frontiers in genetics

authors： Wu C,Huang BE,Chen G,Lovenberg TW,Pocalyko DJ,Yao X

更新日期：2019-04-30 00:00:00

abstract：Background:Despite recent advance in immune therapy, great heterogeneity exists in the outcomes of colorectal cancer (CRC) patients. In this study, we aimed to analyze the immune-related gene (IRG) expression profiles from three independent public databases and develop an effective signature to forecast patient's progn...

journal_title：Frontiers in genetics

authors： Dai S,Xu S,Ye Y,Ding K

更新日期：2020-12-04 00:00:00

abstract：:Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promoting proliferation in ...

journal_title：Frontiers in genetics

authors： Dai B,Wang F,Nie X,Du H,Zhao Y,Yin Z,Li H,Fan J,Wen Z,Wang DW,Chen C

更新日期：2020-11-20 00:00:00

abstract：:Successful seedling establishment depends on the optimum depth of seed placement especially in drought-prone conditions, providing an opportunity to exploit subsoil water and increase winter survival in winter wheat. Coleoptile length is a key determinant for the appropriate depth at which seed can be sown. Thus, unde...

journal_title：Frontiers in genetics

authors： Sidhu JS,Singh D,Gill HS,Brar NK,Qiu Y,Halder J,Al Tameemi R,Turnipseed B,Sehgal SK

更新日期：2020-02-05 00:00:00

abstract：:Common carp is a major aquaculture species worldwide, commonly sold alive but also as processed headless carcass or filets. However, recording of processing yields is impossible on live breeding candidates, and alternatives for genetic improvement are either sib selection based on slaughtered fish, or indirect selecti...

journal_title：Frontiers in genetics

authors： Prchal M,Bugeon J,Vandeputte M,Kause A,Vergnet A,Zhao J,Gela D,Genestout L,Bestin A,Haffray P,Kocour M

更新日期：2018-07-30 00:00:00

abstract：:Cytotoxicity assays of immortalized lymphoblastoid cell lines (LCLs) represent a promising new in vitro approach in pharmacogenomics research. However, previous studies employing LCLs in gene mapping have used simple association methods, which may not adequately capture the true differences in non-linear response prof...

journal_title：Frontiers in genetics

authors： Brown C,Havener TM,Everitt L,McLeod H,Motsinger-Reif AA

更新日期：2011-12-14 00:00:00

abstract：:Recently, a consanguineous family was identified in Israel with three children affected by Infantile Nystagmus and Foveal Hypoplasia, following an autosomal recessive mode of inheritance. A homozygous stop mutation c.1861C > T; p.Q621∗ in the aryl hydrocarbon receptor (AHR) gene (AHR; MIM 600253) was identified that c...

journal_title：Frontiers in genetics

authors： Borovok N,Weiss C,Sharkia R,Reichenstein M,Wissinger B,Azem A,Mahajnah M

更新日期：2020-09-24 00:00:00

abstract：:Rodent models have been extensively used to investigate the cause and mechanisms behind Alzheimer's disease. Despite many years of intensive research using these models we still lack a detailed understanding of the molecular events that lead to neurodegeneration. Although zebrafish lack the complexity of advanced cogn...

journal_title：Frontiers in genetics

authors： Newman M,Ebrahimie E,Lardelli M

更新日期：2014-06-30 00:00:00

abstract：:Leukemia, specifically acute myeloid leukemia (AML), is a common malignancy that can be differentiated into multiple subtypes based on leukemogenic history and etiology. Although genetic aberrations, particularly cytogenetic abnormalities and mutations in known oncogenes, play an integral role in AML development, epig...

journal_title：Frontiers in genetics

authors： Goldman SL,Hassan C,Khunte M,Soldatenko A,Jong Y,Afshinnekoo E,Mason CE

更新日期：2019-03-01 00:00:00

abstract：:Atherosclerosis and its comorbidities are the major contributors to the global burden of death worldwide. Lower extremities arterial disease (LEAD) is a common manifestation of atherosclerotic disease of arteries of lower extremities. MicroRNAs belong to epigenetic factors that regulate gene expression and have not ye...

journal_title：Frontiers in genetics

authors： Bogucka-Kocka A,Zalewski DP,Ruszel KP,Stępniewski A,Gałkowski D,Bogucki J,Komsta Ł,Kołodziej P,Zubilewicz T,Feldo M,Kocki J

更新日期：2019-11-22 00:00:00

abstract：:MicroRNAs are a class of noncoding RNAs that can be involved in the regulation of gene expression in cancers, including lung cancer. Our previous research has shown that miR-486-5p is one of the most downregulated microRNAs in tissue and serum samples of lung cancer as a good diagnostic biomarker. The objective of thi...

journal_title：Frontiers in genetics

authors： Tian F,Wang J,Ouyang T,Lu N,Lu J,Shen Y,Bai Y,Xie X,Ge Q

更新日期：2019-07-26 00:00:00

abstract：:A within-breed genome-wide association study (GWAS) is useful when identifying the QTL that segregates in a breed. However, an across-breed meta-analysis can be used to increase the power of identification and precise localization of QTL that segregate in multiple breeds. Precise localization will allow including QTL ...

journal_title：Frontiers in genetics

authors： Marete AG,Guldbrandtsen B,Lund MS,Fritz S,Sahana G,Boichard D

更新日期：2018-11-06 00:00:00

abstract：:The genetic diversity of the sheep breeds in the Arab countries might be considered to be a mirror of the ecology of the region. In this study, the genetic structure and diversity of sheep breeds from Saudi Arabia (Harri, Najdi, Naemi, Arb, and Rufidi) and Awassi sheep from Jordan as an out-group were investigated usi...

journal_title：Frontiers in genetics

authors： Al-Atiyat RM,Aljumaah RS,Alshaikh MA,Abudabos AM

更新日期：2018-09-25 00:00:00

abstract：:Beef tenderness, a complex trait affected by many factors, is economically important to beef quality, industry, and consumer's palatability. In this study, RNA-Seq was used in network analysis to better understand the biological processes that lead to differences in beef tenderness. Skeletal muscle transcriptional pro...

journal_title：Frontiers in genetics

authors： Gonçalves TM,de Almeida Regitano LC,Koltes JE,Cesar ASM,da Silva Andrade SC,Mourão GB,Gasparin G,Moreira GCM,Fritz-Waters E,Reecy JM,Coutinho LL

更新日期：2018-10-05 00:00:00

abstract：:HFE-related Hemochromatosis is the most common genetic iron overload disease in European populations, particularly of Nordic or Celtic ancestry. It is reported that the HFE p.C282Y mutation is present in 1/10 people of northern European descent, resulting in one in two hundred people will be homozygous. However, the H...

journal_title：Frontiers in genetics

authors： Zhang W,Wang X,Duan W,Xu A,Zhao X,Huang J,You H,Brissot P,Ou X,Jia J

更新日期：2020-02-21 00:00:00

abstract：:Animal models are invaluable for biomedical research, especially in the context of rare diseases, which have a very low prevalence and are often complex. Concretely mouse models provide key information on rare disease mechanisms and therapeutic strategies that cannot be obtained by using only alternative methods, and ...

journal_title：Frontiers in genetics

authors： Murillo-Cuesta S,Artuch R,Asensio F,de la Villa P,Dierssen M,Enríquez JA,Fillat C,Fourcade S,Ibáñez B,Montoliu L,Oliver E,Pujol A,Salido E,Vallejo M,Varela-Nieto I

更新日期：2020-10-14 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23), which is involved in the regulation of vitamin D, is an emerging independent risk factor for cardiovascular diseases. Previous studies have demonstrated a positive association between FGF23 and stroke. In this study, we aimed to assess the association of FGF23 with ischemic stroke ...

journal_title：Frontiers in genetics

authors： Zheng K,Lin L,Cui P,Liu T,Chen L,Yang C,Jiang W

更新日期：2020-12-23 00:00:00

abstract：:Excessive fat deposition can cause chicken health problem, and affect production efficiency by causing great economic losses to the industry. However, the molecular underpinnings of the complex adiposity trait remain elusive. In the current study, we constructed and compared the gene co-expression networks on four tra...

journal_title：Frontiers in genetics

authors： Gao Z,Ding R,Zhai X,Wang Y,Chen Y,Yang CX,Du ZQ

更新日期：2020-05-29 00:00:00

abstract：:Selective breeding programs aiming to increase the productivity and profitability of the sheep meat industry use elite, progeny tested sires. The broad genetic traits of primary interest in the progeny of these sires include skeletal muscle yield, fat content, eating quality, and reproductive efficiency. Natural mutat...

journal_title：Frontiers in genetics

authors： Tellam RL,Cockett NE,Vuocolo T,Bidwell CA

更新日期：2012-08-29 00:00:00

abstract：:For the past several decades, research in understanding the molecular basis of human muscle aging has progressed significantly. However, the development of accessible tissue-specific biomarkers of human muscle aging that may be measured to evaluate the effectiveness of therapeutic interventions is still a major challe...

journal_title：Frontiers in genetics

authors： Mamoshina P,Volosnikova M,Ozerov IV,Putin E,Skibina E,Cortese F,Zhavoronkov A

更新日期：2018-07-12 00:00:00

abstract：OBJECTIVE:We report the first pediatric specific Phenome-Wide Association Study (PheWAS) using electronic medical records (EMRs). Given the early success of PheWAS in adult populations, we investigated the feasibility of this approach in pediatric cohorts in which associations between a previously known genetic variant...

journal_title：Frontiers in genetics

authors： Namjou B,Marsolo K,Caroll RJ,Denny JC,Ritchie MD,Verma SS,Lingren T,Porollo A,Cobb BL,Perry C,Kottyan LC,Rothenberg ME,Thompson SD,Holm IA,Kohane IS,Harley JB

更新日期：2014-11-18 00:00:00

abstract：:History of East-Central Europe has been intertwined with the history of Turks in the past. A significant part of this region of Europe has been fallen under Ottoman control during the 150 years of Ottoman occupation in the 16-17th centuries. The presence of the Ottoman Empire affected this area not only culturally but...

journal_title：Frontiers in genetics

authors： Bánfai Z,Melegh BI,Sümegi K,Hadzsiev K,Miseta A,Kásler M,Melegh B

更新日期：2019-06-13 00:00:00

abstract：:Cardiovascular diseases are a leading cause of morbidity and mortality in Western societies. It is now well established that microRNAs (miRNAs) are determinant regulators in various medical conditions including cardiovascular diseases. The recent discovery that miRNAs, while associated with different carriers, can be ...

journal_title：Frontiers in genetics

authors： Kinet V,Halkein J,Dirkx E,Windt LJ

更新日期：2013-11-12 00:00:00