Function and evolution of microRNAs in eusocial Hymenoptera.

abstract：:Influenza A virus (IAV) is a segmented negative-stranded RNA virus that brings a potentially serious threat to public health and animal husbandry. Mast cells play an important role in both the inherent and adaptive immune response. Previous studies have indicated that mast cells support the productive replication of H...

journal_title：Frontiers in genetics

authors： Huo C,Wu H,Xiao J,Meng D,Zou S,Wang M,Qi P,Tian H,Hu Y

更新日期：2019-06-21 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders. Several studies have confirmed the co-existence of other neuropsychiatric disorders with ADHD. Out of 106 individuals suspected to have ADHD, eight Saudi Arabian pediatric patients were diagnosed with ADHD using a d...

journal_title：Frontiers in genetics

authors： Bogari NM,Al-Allaf FA,Aljohani A,Taher MM,Qutub NA,Alhelfawi S,Alobaidi A,Alqudah DM,Banni H,Dairi G,Amin AA

更新日期：2020-12-15 00:00:00

abstract：:Background: Porcine respiratory and reproductive syndrome virus (PRRSV) is a single-stranded RNA virus member that infects pigs and causes losses to the commercial industry reaching upward of a billion dollars annually in combined direct and indirect costs. The virus can be separated into etiologies that contain multi...

journal_title：Frontiers in genetics

authors： Fleming DS,Miller LC

更新日期：2019-08-02 00:00:00

abstract：:Osteogenesis Imperfecta (OI) is a rare inherited bone dysplasia, which is mainly caused by mutations in genes encoding type I collagen including COL1A1 and COL1A2. It has been well established to identify the classical variants as well as consensus splicing-site-variants in these genes in our previous studies. However...

journal_title：Frontiers in genetics

authors： Li L,Cao Y,Zhao F,Mao B,Ren X,Wang Y,Guan Y,You Y,Li S,Yang T,Zhao X

更新日期：2019-10-18 00:00:00

abstract：Background:Lung disease phenotype varies widely even in the F508del (homozygous) genotype. Leukocyte-driven inflammation is important for pulmonary disease pathogenesis in cystic fibrosis (CF). Blood cytokines correlate negatively with pulmonary function in F508del homozygous patients, and gap junction proteins (GJA) m...

journal_title：Frontiers in genetics

authors： Horn T,Ludwig M,Eickmeier O,Neerinex AH,Maitland-van der Zee AH,Smaczny C,Wagner TOF,Schubert R,Zielen S,Majoor C,Bos LD,Schmitt-Grohé S

更新日期：2020-10-28 00:00:00

abstract：:Histone proteins are dynamically modified to mediate a variety of cellular processes including gene transcription, DNA damage repair, and apoptosis. Regulation of these processes occurs through the recruitment of non-histone proteins to chromatin by specific combinations of histone post-translational modifications (PT...

journal_title：Frontiers in genetics

authors： Karch KR,Denizio JE,Black BE,Garcia BA

更新日期：2013-12-20 00:00:00

abstract：:Background: Limb-girdle muscular dystrophy (LGMD) is an increasingly heterogeneous category of inherited muscle diseases, mainly affecting the muscles of shoulder areas and the hip, segregating in both autosomal recessive and dominant manner. To-date, thirty-one loci have been identified for LGMD including seven autos...

journal_title：Frontiers in genetics

authors： Younus M,Ahmad F,Malik E,Bilal M,Kausar M,Abbas S,Shaheen S,Kakar MU,Alfadhel M,Umair M

更新日期：2019-01-23 00:00:00

abstract：:The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as 'at-risk'. In the present study, comparative population genomics analyses of Galway sheep and other sheep populations of European origin were used to investigate the microevolution and recen...

journal_title：Frontiers in genetics

authors： McHugo GP,Browett S,Randhawa IAS,Howard DJ,Mullen MP,Richardson IW,Park SDE,Magee DA,Scraggs E,Dover MJ,Correia CN,Hanrahan JP,MacHugh DE

更新日期：2019-10-08 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative and progressive disease, which often causes irreversible damages to the cerebrum. The pathogenesis of AD is far from being fully understood, while there are some popular hypotheses. So far, the diagnosis of AD relies only on clinical screening in the form of imaging tech...

journal_title：Frontiers in genetics

authors： Wang L,Liu ZP

更新日期：2019-03-12 00:00:00

abstract：:Cotton (Gossypium spp.) is the most important natural fiber crop in the world. The R2R3-MYB gene family is a large gene family involved in many plant functions including cotton fiber development. Although previous studies have reported its phylogenetic relationships, gene structures, and expression patterns in tetrapl...

journal_title：Frontiers in genetics

authors： Wang N,Ma Q,Ma J,Pei W,Liu G,Cui Y,Wu M,Zang X,Zhang J,Yu S,Ma L,Yu J

更新日期：2019-08-15 00:00:00

abstract：:Innate immune response is triggered by pathogen components, like lipopolysaccharides (LPS) of gram-negative bacteria. LPS initiates Toll-like receptor 4 (TLR4) signaling, which involves mitogen activated protein kinases (MAPK) and nuclear factor kappa B (NFκB) in different pathway branches and ultimately induces infla...

journal_title：Frontiers in genetics

authors： Ostareck DH,Ostareck-Lederer A

更新日期：2019-02-04 00:00:00

abstract：:While substantial progress has been made in finding genetic variants associated with nicotine dependence (ND), a large proportion of the genetic variants remain undiscovered. The current research focuses have shifted toward uncovering rare variants, gene-gene/gene-environment interactions, and structural variations pr...

journal_title：Frontiers in genetics

authors： Zhang X,Lan T,Wang T,Xue W,Tong X,Ma T,Liu G,Lu Q

更新日期：2019-05-17 00:00:00

abstract：:In light of the complex nature of multiple sclerosis (MS) and the recently estimated contribution of low-frequency variants into disease, decoding its genetic risk components requires novel variant prioritization strategies. We selected, by reviewing MS Genome Wide Association Studies (GWAS), 107 candidate loci marked...

journal_title：Frontiers in genetics

authors： Ziliotto N,Marchetti G,Scapoli C,Bovolenta M,Meneghetti S,Benazzo A,Lunghi B,Balestra D,Laino LA,Bozzini N,Guidi I,Salvi F,Straudi S,Gemmati D,Menegatti E,Zamboni P,Bernardi F

更新日期：2019-06-26 00:00:00

abstract：:Over millions of years, vertebrate species populated vast environments spanning the globe. Among the most challenging habitats encountered were those with limited availability of oxygen, yet many animal and human populations inhabit and perform life cycle functions and/or daily activities in varying degrees of hypoxia...

journal_title：Frontiers in genetics

authors： Pamenter ME,Hall JE,Tanabe Y,Simonson TS

更新日期：2020-07-22 00:00:00

abstract：Objective:Extensive literature put forward the link between sleep and type 2 diabetes mellitus (T2DM), however, little is known about the underlying causality of the associations. Here we aim to assess the causal relationships between five major sleep-related traits and T2DM. Design Setting and Participants:Two-sample...

journal_title：Frontiers in genetics

authors： Gao X,Sun H,Zhang Y,Liu L,Wang J,Wang T

更新日期：2020-12-15 00:00:00

abstract：:The Jats represent a large ethnic community that has inhabited the northwest region of India and Pakistan for several thousand years. It is estimated the community has a population of over 123 million people. Many historians and academics have asserted that the Jats are descendants of Aryans, Scythians, or other ancie...

journal_title：Frontiers in genetics

authors： Mahal DG,Matsoukas IG

更新日期：2017-09-20 00:00:00

abstract：:The autotetraploid fish (4n = 200, RRRR) (abbreviated as 4nRR) resulted from the whole genome duplication of red crucian carp (Carassius auratus red var., 2n = 100, RR) (abbreviated as RCC). During investigation of the influence of polyploidization on organization and evolution of the multigene family of 5S rDNA, mole...

journal_title：Frontiers in genetics

authors： Qin Q,Liu Q,Wang C,Cao L,Zhou Y,Qin H,Zhao C,Liu S

更新日期：2019-05-15 00:00:00

abstract：:At the time of translation, nascent proteins are thought to be sorted into their final subcellular localization sites, based on the part of their amino acid sequences (i.e., sorting or targeting signals). Thus, it is interesting to computationally recognize these signals from the amino acid sequences of any given prot...

journal_title：Frontiers in genetics

authors： Imai K,Nakai K

更新日期：2020-11-25 00:00:00

abstract：:Liver fibrosis resulting from chronic liver damage constitutes a major health care burden worldwide; however, no antifibrogenic agents are currently available. Our previous study reported that the small molecule NPLC0393 extracted from the herb Gynostemma pentaphyllum exerts efficient antifibrotic effects both in vivo...

journal_title：Frontiers in genetics

authors： Huang H,Wang K,Liu Q,Ji F,Zhou H,Fang S,Zhu J

更新日期：2020-11-04 00:00:00

abstract：:Liver is the main organ of lipid metabolism in chicken, especially for laying hens. To explore the molecular mechanism of lipid metabolism in chicken, five novel genes discovered in chicken liver tissue were systematically studied. Bioinformatic analysis was used to analyze the gene characteristics. The expression pat...

journal_title：Frontiers in genetics

authors： Li H,Li Y,Yang L,Zhang D,Liu Z,Wang Y,Han R,Li G,Li Z,Tian Y,Kang X,Liu X

更新日期：2020-03-31 00:00:00

abstract：:One of the challenges in the analysis of large data sets, particularly in a population-based setting, is the ability to perform comparisons across projects. This has to be done in such a way that the integrity of each individual project is maintained, while ensuring that the data are comparable across projects. These ...

journal_title：Frontiers in genetics

authors： Fejes AP,Jones MJ,Kobor MS

更新日期：2014-09-18 00:00:00

abstract：:Genome-wide Association Studies (GWAS) result in millions of summary statistics ("z-scores") for single nucleotide polymorphism (SNP) associations with phenotypes. These rich datasets afford deep insights into the nature and extent of genetic contributions to complex phenotypes such as psychiatric disorders, which are...

journal_title：Frontiers in genetics

authors： Holland D,Wang Y,Thompson WK,Schork A,Chen CH,Lo MT,Witoelar A,Schizophrenia Working Group of the Psychiatric Genomics Consortium.,Enhancing Neuro Imaging Genetics through Meta Analysis Consortium.,Werge T,O'Donovan M,Andreassen OA

更新日期：2016-02-16 00:00:00

abstract：BACKGROUND:Non-synonymous single-nucleotide polymorphisms (nsSNPs) within the coding regions of genes causing amino acid substitutions (AASs) may have a large impact on protein function. The possibilities to identify nsSNPs across genomes have increased notably with the advent of next-generation sequencing technologies...

journal_title：Frontiers in genetics

authors： Li X,Kierczak M,Shen X,Ahsan M,Carlborg O,Marklund S

更新日期：2013-03-06 00:00:00

abstract：:Vitamin D receptor (VDR) gene polymorphisms were reported to influence blood lead levels (BLL) and the response of subjects to the symptoms of lead toxicity. However, no studies have been conducted in the Saudi Arabian population which has unique ethnicity and socio-demographic features. This study examined the polymo...

journal_title：Frontiers in genetics

authors： Shaik AP,Alsaeed AH,Faiyaz-Ul-Haque M,Alsaeed MA,Alyousef AA,Bammidi VK,Shaik AS

更新日期：2019-04-26 00:00:00

abstract：:Exosomes are biomolecular nanostructures released from cells. They carry specific biomolecular information and are mainly researched for their exquisite properties as a biomarker source and delivery system. We introduce exosomes in the context of other extracellular vesicles, describe their biophysical isolation and c...

journal_title：Frontiers in genetics

authors： de la Torre Gomez C,Goreham RV,Bech Serra JJ,Nann T,Kussmann M

更新日期：2018-03-27 00:00:00

abstract：:Cardiovascular diseases are a leading cause of morbidity and mortality in Western societies. It is now well established that microRNAs (miRNAs) are determinant regulators in various medical conditions including cardiovascular diseases. The recent discovery that miRNAs, while associated with different carriers, can be ...

journal_title：Frontiers in genetics

authors： Kinet V,Halkein J,Dirkx E,Windt LJ

更新日期：2013-11-12 00:00:00

abstract：:Few studies have been conducted to explore the influence of the catechol-o-methyltransferase (COMT) genotype on the severity of and treatment efficacy on auditory verbal hallucination (AVH) symptoms in healthy individuals with AVHs (Hi-AVHs). We hypothesized that the efficacy of dopamine antagonist treatment on AVHs i...

journal_title：Frontiers in genetics

authors： Zhuo C,Xu Y,Zhang L,Jing R,Zhou C

更新日期：2019-03-06 00:00:00

abstract：:Undergraduate students in the biomedical sciences are often interested in future health-focused careers. This presents opportunities for instructors in genetics, molecular biology, and cancer biology to capture their attention using lab experiences built around clinically relevant data. As biomedical science in genera...

journal_title：Frontiers in genetics

authors： Hankey W,Zanghi N,Crow MM,Dow WH,Kratz A,Robinson AM,Robinson MR,Segarra VA

更新日期：2020-12-16 00:00:00

abstract：:Background: Papillary renal cell carcinoma (PRCC), although the second-most common type of renal cell carcinoma, still lacks specific biomarkers for diagnosis, treatment, and prognosis. TopBP1-interacting checkpoint and replication regulator (TICRR) is a DNA replication initiation regulator upregulated in various canc...

journal_title：Frontiers in genetics

authors： Xia S,Lin Y,Lin J,Li X,Tan X,Huang Z

更新日期：2021-01-11 00:00:00

abstract：:Software which simulates, infers, or analyzes ancestral recombination graphs (ARGs) faces the problem of communicating them. Existing formats omit information either about the location of recombinations along the chromosome or the position of recombinations relative to the branching topology. We present a specializati...

journal_title：Frontiers in genetics

authors： McGill JR,Walkup EA,Kuhner MK

更新日期：2013-08-07 00:00:00