当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Mechanism of Premature Apoptosis in CD1d-Restricted Natural Killier T Cells From Human Peripheral Blood During the Induction of Proliferation In Vitro.

Mechanism of Premature Apoptosis in CD1d-Restricted Natural Killier T Cells From Human Peripheral Blood During the Induction of Proliferation In Vitro.

Abstract：

OBJECTIVE:A preliminary investigation on the proliferation and cultivation process of natural killer T cells (NKT) was carried out. We provide reference data for future NKT-related research and development. METHODS:Peripheral blood mononuclear cells (PBMCs) were isolated from healthy people and were induced by α-galactosylceramide (α-GalCer). The phenotypic changes of the cells and the activation and apoptosis of Caspase-3 were recorded for 3-4 weeks. RESULTS:The proliferation of the NKT cells continued for approximately 3 weeks, and then apoptosis started to occur. The activity of Caspase-3 was maintained at a high level from the second week. The responses of individual human NKT cells to α-GalCer stimulation differed significantly. CONCLUSION:The proliferation of the NKT cells continued for approximately 3 weeks, and then apoptosis Semiconstitutively started to occur. The activity of Caspase-3 was maintained at a high level from the second week. The responses of individual human NKT cells to α-GalCer stimulation differed significantly.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Gao L,Fan Y,Yang Y,Xie R,Yang J,Chen Z

doi

10.1016/j.transproceed.2018.02.071

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

1514-1518

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(18)30223-9

journal_volume

50

pub_type

杂志文章

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