Abstract:
:Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes immunosuppression and enhances susceptibility to secondary infection, resulting in great economic losses. Although ALV-J-induced immunosuppression has been well established, the underlying molecular mechanism for such induction is still unclear. Here, we report that the inhibitory effect of ALV-J infection on type I interferon expression is associated with the down-regulation of transcriptional regulator NF-κB in host cells. We found that ALV-J possess the inhibitory effect on type I interferon production in HD11 cells and that ALV-J causes the up-regulation of IκBα and down-regulation of NF-κB p65, and that ALV-J blocks the phosphorylation of IκBα on Ser32/36 amino acid residues. Collectively, our findings provide insights into the pathogenesis of ALV-J.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Lin W,Xu Z,Yan Y,Zhang H,Li H,Chen W,Chen F,Xie Qdoi
10.3389/fmicb.2018.01089subject
Has Abstractpub_date
2018-05-25 00:00:00pages
1089issn
1664-302Xjournal_volume
9pub_type
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