Abstract:
:Nonsteroid anti-inflammatory drugs are often used to treat myalgias and arthralgias in enteroviral infections, but their effects on acute viral myocarditis are unknown. The effect of the nonsteroidal anti-inflammatory drug, ibuprofen, on acute viral myocarditis was studied in 75 four week old male BALB/c mice infected with 1.75 X 10(7) plaque-forming units of Coxsackie virus B3 on day 0. Ibuprofen was given intraperitoneally at a dose of 15 mg/kg body weight daily. The mice were assigned to four groups--Group I, 18 uninfected mice given ibuprofen on days 1 to 14; Group II, 18 infected, untreated mice; Group III, 20 infected mice given ibuprofen on days 1 to 14; and Group IV, 17 infected mice given ibuprofen on days 7 to 14. Nine animals in Group I, eight in Group II and seven in Group III were killed on day 7; the remaining mice were killed on day 14. Heart viral cultures and histologic analysis were done. Cultures at days 7 and 14 were all negative. Inflammation and necrosis analyzed in each animal were graded 0 to 4, with grade 4 representing widespread inflammation and necrosis. The heart was histologically normal in all 18 uninfected mice (Group I) given ibuprofen only. Inflammation and necrosis were not significantly different in Group II (infected, untreated) and Group III (infected, treated beginning day 1) mice killed at day 7. Inflammation scores of mice killed on day 14 were 2.1 +/- 0.6 (Group II), 3.1 +/- 0.7 (Group III) and 2.9 +/- 1.0 (Group IV infected, treated days 7 to 14).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Costanzo-Nordin MR,Reap EA,O'Connell JB,Robinson JA,Scanlon PJdoi
10.1016/s0735-1097(85)80312-0subject
Has Abstractpub_date
1985-11-01 00:00:00pages
1078-82issue
5eissn
0735-1097issn
1558-3597pii
S0735-1097(85)80312-0journal_volume
6pub_type
杂志文章abstract:OBJECTIVES:This study was designed to examine the relation between the timing and adequacy of perfusion of the infarct bed and changes in ventricular size and the extent of abnormal wall motion after acute myocardial infarction. METHODS:A validated echocardiographic mapping technique was used to measure the left ventr...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/0735-1097(93)90101-6
更新日期:1993-03-01 00:00:00
abstract::Premature opening of the pulmonary valve in mid-diastole before atrial systole was observed during inspiration in a patient with extensive right ventricular infarction. Transient inspiratory elevation of right ventricular diastolic pressure to a level exceeding pulmonary artery pressure was documented. Although forwar...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(85)80061-9
更新日期:1985-02-01 00:00:00
abstract:OBJECTIVES:This study was designed to evaluate the relationship among blood pressure (BP) levels, risk of sudden cardiac death (SCD), and benefit of the implantable cardioverter-defibrillator (ICD) in patients with ischemic left ventricular (LV) dysfunction. BACKGROUND:Low BP has been shown to be associated with incre...
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:2016-12-20 00:00:00
abstract:BACKGROUND:Routine apolipoprotein (apo) measurements for cardiovascular disease (CVD) are restricted to apoA-I and apoB. Here, the authors measured an unprecedented range of apolipoproteins in a prospective, population-based study and relate their plasma levels to risk of CVD. OBJECTIVES:This study sought to measure a...
journal_title:Journal of the American College of Cardiology
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更新日期:2017-02-21 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2009-08-18 00:00:00
abstract:OBJECTIVES:This study was designed to investigate whether the addition of N-terminal pro-B-type natriuretic peptide-guided, intensive patient management (BM) to multidisciplinary care (MC) improves outcome in patients following hospitalization due to heart failure (HF). BACKGROUND:Patients hospitalized due to HF exper...
journal_title:Journal of the American College of Cardiology
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更新日期:2010-02-16 00:00:00
abstract:OBJECTIVES:This study sought to assess whether baseline and change in contemporary sensitive troponin I (TnI) levels predicts coronary heart disease (CHD) death and myocardial infarction (MI), and to determine the effects of pravastatin on TnI levels. BACKGROUND:The role of troponins in predicting long-term outcomes i...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jacc.2013.08.1643
更新日期:2014-02-04 00:00:00
abstract::Epidemiologic data point to racial differences in cardiac adaptation to hypertension. In this study, echocardiography and measurement of systemic hemodynamics were performed in 30 black and 30 white patients with untreated essential hypertension. Each black patient was matched with a white patient for age, sex and mea...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(83)80150-8
更新日期:1983-05-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(88)90368-3
更新日期:1988-07-01 00:00:00
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更新日期:1995-06-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jacc.2009.11.102
更新日期:2010-08-03 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,实务指引,评审
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更新日期:2006-10-03 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
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更新日期:2000-11-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/j.jacc.2006.04.099
更新日期:2006-10-17 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(91)90947-8
更新日期:1991-05-01 00:00:00
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doi:10.1016/j.jacc.2006.01.074
更新日期:2006-06-20 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1998-12-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-09-19 00:00:00
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更新日期:2002-07-03 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2015-08-25 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2008-04-08 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2004.10.053
更新日期:2005-02-15 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
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更新日期:1995-03-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
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更新日期:2008-08-26 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1995-03-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2003-02-05 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2008.08.024
更新日期:2008-11-11 00:00:00
abstract:OBJECTIVES:We sought to assess survival among patients with diabetes and multivessel coronary artery disease (MVD) after percutaneous coronary intervention (PCI) and after coronary artery bypass grafting surgery (CABG). BACKGROUND:The Bypass Angioplasty Revascularization Investigation (BARI) demonstrated that diabetic...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:2001-03-15 00:00:00
abstract:OBJECTIVES:The purpose of this study was to examine the efficacy and safety of four doses of ambrisentan, an oral endothelin type A receptor-selective antagonist, in patients with pulmonary arterial hypertension (PAH). BACKGROUND:Pulmonary arterial hypertension is a life-threatening and progressive disease with limite...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.jacc.2005.04.050
更新日期:2005-08-02 00:00:00