Factors Related to Frailty Associated with Clinical Deterioration After Meningioma Surgery in the Elderly.

Abstract:

BACKGROUND:Older patients are increasingly presenting for surgery with intracranial meningioma because of progress with diagnostic imaging and longer life expectancy. However, older patients have many problems, such as comorbidities and reduced physiological capacity reflected in the frailty index. This study examines the factors affecting clinical deterioration after surgery in older patients, particularly factors associated with frailty. METHODS:Two hundred sixty-five patients older than 65 years underwent surgical resection of meningioma at Hiroshima University and related hospitals between 2000 and 2016. Karnofsky Performance Status (KPS) scores before and after surgery were evaluated. Factors related to the deterioration of KPS were analyzed with multivariate logistic regression modeling, including body mass index and serum albumin. RESULTS:KPS score deteriorated compared with preoperative score in 56 patients at discharge and in 40 patients at 3 months later, and 2 patients died within 1 year after surgery. Multivariate logistic regression analysis in addition to preoperative body mass index and serum albumin indicated skull base tumor location (odds ratio [OR], 4.67; 95% confidence interval [CI], 2.02-10.8) and serum albumin (OR, 2.38; 95% CI, 1.06-5.34) were risk factors for deterioration of KPS score at discharge. Age (OR, 0.91; 95% CI, 0.85-0.98), skull base tumor location (OR, 4.32; 95% CI, 1.45-12.9), tumor size (OR, 1.03; 95% CI, 1.00-1.05), and serum albumin (OR, 3.53; 95% CI, 1.29-9.61) were significant risk factors for perioperative intracranial complications. CONCLUSIONS:Skull base tumor location and serum albumin correlated with deterioration of clinical status after surgery.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Isobe N,Ikawa F,Tominaga A,Kuroki K,Sadatomo T,Mizoue T,Hamasaki O,Matsushige T,Abiko M,Mitsuhara T,Kinoshita Y,Takeda M,Kurisu K

doi

10.1016/j.wneu.2018.07.080

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

e167-e173

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(18)31558-4

journal_volume

119

pub_type

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