Abstract：
INTRODUCTION:Ventriculitis is a serious infection associated with high mortality even when both intravenous (IV) and intrathecal (IT) antibiotics are administered. Poor outcome in patients with ventriculitis indicates the need to be more aggressive in our attempts to expeditiously eradicate the infection. The purpose of this study was to evaluate the role of endoscopic lavage (EL) in patients with severe purulent ventriculitis, unresponsive to IV and IT antibiotics. METHODS:All consecutive patients with severe ventriculitis caused by multidrug-resistant gram-negative bacteria, undergoing EL after failure of prolonged courses of IV and IT antibiotics, were included in the study. The outcome in all these patients was otherwise expected to be uniformly dismal. RESULTS:There were 5 males and 2 females. The age range was one month to 45 years. All patients had frank intraventricular pus. Acinetobacter baumannii was the most common organism grown in cultures. Two patients had multiple bacterial growth in cerebrospinal fluid cultures. The duration of pre-EL IV/IT antibiotics ranged from 3 to 8 weeks. Microbiological cure was achieved in all (7/7) and clinical cure in 86% of patients (6/7). One patient died despite achieving cerebrospinal fluid sterilization 3 months later as a result of progressive white matter edema. CONCLUSIONS:The addition of IT antibiotics has resulted in improved outcome in patients with ventriculitis; however, some patients continue to be unresponsive to antibiotics. EL can play a complementary role in eradicating such recalcitrant infections. EL should be considered in any patient with ventriculitis, if infection persists even after ∼7-10 days of IVand IT antibiotics.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Kumar A,Agrawal D,Sharma BSdoi
10.1016/j.wneu.2016.06.022subject
Has Abstractpub_date
2016-09-01 00:00:00pages
315-23eissn
1878-8750issn
1878-8769pii
S1878-8750(16)30407-7journal_volume
93pub_type
杂志文章abstract：OBJECTIVE:The tumor microenvironment greatly influences tumor formation, invasion, and progression. The ESTIMATE (Estimation of STromal and Immune cells in MAlignant Tumor tissues) algorithm quantifies stromal and immune components in a tumor, reflecting the tumor microenvironment. This study aimed to explore key progn...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.08.253
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Several factors associated with interrupted and continuous suturing techniques affect the quality of bypass anastomosis. It is difficult to determine the impact of these factors during surgery. The primary objective of this study was to evaluate factors with the potential to influence the quality of bypass a...
journal_title：World neurosurgery
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Orbital arteriovenous fistula (AVF) is a rare entity with only 17 cases reported so far. An arteriovenous hemangioma is a distinct entity of an angioma that most frequently affects the skin. However, to our knowledge, there has not been a case arising in the orbit. CASE DESCRIPTION:A previously healthy, 73-...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.11.003
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abstract：OBJECTIVE:This report describes 2 techniques for controlling otherwise difficult-to-control hemorrhage from choanoid bony foramina. METHODS:Medical records of 3 patients in whom vigorous and difficult-to-control bleeding from choanoid cranial foramina was successfully halted are reviewed. RESULTS:In 2 patients, vigor...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.01.128
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:The Internet has become a popular resource for patients to research diagnosed or suspected medical diseases. Medical institutions provide comprehensive online education resources about various conditions to the general public. The U.S. National Institutes of Health and American Medical Association recommend ...
journal_title：World neurosurgery
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doi：10.1016/j.wneu.2019.11.109
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Sufficient visualization of the operating field is crucial for success in surgery and is important especially concerning minimally invasive and deep approaches in spine surgery. METHODS:The spinal microsurgical approach was imitated using an isolated box that was accessed with different devices. Different l...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.06.013
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:In academic specialties such as neurosurgery, bibliometrics are often used to guide readers, academic institutes, and researchers to make objective assessment of journals. Recently, new indices have been developed to overcome the shortcomings of the widely used Impact Factor. The objective of our study was t...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.07.144
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:This study modified the traditional extreme lateral lumbar interbody fusion (XLIF) surgery and was intended to reduce the approach related to lumbar plexus injury. METHODS:The patients receiving a new modified XLIF for treatment of lumbar degenerative diseases since September 2017 in our hospital were retro...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.02.167
更新日期：2020-06-01 00:00:00
abstract：:Acute lymphoblastic lymphoma is a malignant hematologic disease in childhood but rarely initially involves epidural compartment in adults. A 20-year-old male presented with progressive osphyalgia with constipation. Contrasted magnetic resonance imaging showed multiple vertebrae of hypointense T1 signals and an intrasp...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.09.130
更新日期：2018-01-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,随机对照试验
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更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Decompressive craniectomy procedures are performed in patients with malignant intracranial hypertension. A bone flap is removed to relieve pressure. Later, a second operation is performed to reconstruct the skull after brain swelling has resolved. This surgical treatment would be improved if it were possible...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.08.095
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:The caroticoclinoid bar (CCB) is implicated in both transcranial and endonasal surgery. Its morphology reflects differences in the microsurgical anatomy of the parasellar area while its manipulation during an anterior or middle clinoidectomy can result in ICA injury. Although safe surgical access to the para...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2019.01.017
更新日期：2019-01-21 00:00:00
abstract：BACKGROUND:Spinal hemangioblastomas account for 1%-5% of all spinal cord tumors. Although spinal hemangioblastomas are rare, it is exceedingly rare to have a case of intradural extramedullary hemangioblastoma of the spine, especially in isolation without von Hippel-Lindau syndrome. The purpose of this report is to pres...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.10.104
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:The outpatient lumbar discectomy procedures have been established for more than 2 decades. However, especially in Europe, there are still obstacles to the development of these procedures, which may be related to medicoeconomic imperatives, and to several factors concerning both surgeons and patients. We describ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.07.065
更新日期：2017-10-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.03.046
更新日期：2016-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2016.08.010
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Cerebrospinal fluid (CSF)-containing cysts at the level of the choroidal fissure are rare embryological entities infrequently described in the literature because of their benign nature. On the occasion of a case series, we present an overview of the literature and discuss anatomical and embryological locatio...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2010.12.056
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Alveolar soft part sarcoma (ASPS) is a rare, malignant soft-tissue neoplasm typically seen in young adults that possesses an unusual tendency to metastasize. Metastases to the intramedullary compartment of the spinal cord, however, are exceptionally rare and have not been described in the literature. CASE D...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.04.100
更新日期：2017-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2011.02.021
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:The anterior-only surgical procedure, including discectomy, open reduction, fusion, and fixation, is a recommended approach in the treatment of cervical facet dislocations. This approach has a reduction failure rate of up to 40%. When it fails, a posterior approach is usually required. OBJECTIVE:To report a...
journal_title：World neurosurgery
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doi：10.1016/j.wneu.2019.04.153
更新日期：2019-08-01 00:00:00
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journal_title：World neurosurgery
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doi：10.1016/j.wneu.2018.09.214
更新日期：2019-02-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.06.030
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Traditionally, the dural venous sinuses have been described only in the cranium. However, anecdotally, during various neurosurgical intradural procedures in the lumbosacral spine, we noticed an intradural collection of blood. With no prior studies on this in the extant medical literature, the following anato...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.01.116
更新日期：2017-05-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.08.099
更新日期：2016-12-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2014.07.031
更新日期：2014-12-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.03.200
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to describe the effectiveness of local vascularized flaps for the repair of various skull base defects. METHODS:We analyzed a cohort of 138 patients undergoing skull base surgery in a retrospective review of all head and neck surgical oncology cases done at a major tertiary care...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2012.11.073
更新日期：2015-01-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.01.163
更新日期：2019-05-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.09.142
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:Deep brain stimulation (DBS) is an effective treatment for movement disorders. Stereotactic electrode placement can be guided by intraoperative imaging, which also allows for immediate intraoperative quality control. This article is about implementation and refining a workflow applying intraoperative computed...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.12.079
更新日期：2018-12-27 00:00:00
