当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > New Bis copper complex ((Z) -4 - ((4-chlorophenyl) amino) -4-oxobut-2-enoyl) oxy): Cytotoxicity in 4T1 cells and their toxicogenic potential in Swiss mice.

New Bis copper complex ((Z) -4 - ((4-chlorophenyl) amino) -4-oxobut-2-enoyl) oxy): Cytotoxicity in 4T1 cells and their toxicogenic potential in Swiss mice.

Abstract：

:Copper (II) complexes are promising in the development of new synthetic models for cancer treatment. In this context, we synthesized a new copper complex containing the pharmacophore group 1,4-dioxo-2-butenyl, the Bis(((Z)-4-((4-chlorophenyl) amino)-4-oxobut-2-enoyl)oxy) copper compound and we evaluated its antitumor activity in 4 T1 murine mammary adenocarcinoma cells and their toxicogenic effect in Swiss mice. The compound demonstrated cytotoxicity and genotoxicity to 4 T1 cells, and after cell cycle arrest in G1, which occurred by the increase in ATM and p21 expression, it induced the cells to apoptosis by increasing BAX and caspase-7. In vivo the compound was genotoxic in mice but did not show permanent damage, observed by the absence of increased micronucleus frequency, and did not induce changes in the biometric parameters of the animals. These results indicate that the new copper complex, described firstly in this work, presents therapeutic potential for breast cancer.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

de Oliveira EJT,Pessatto LR,de Freitas RON,Pelizaro BI,Rabacow APM,Vani JM,Monreal ACD,Mantovani MS,de Azevedo RB,Antoniolli-Silva ACMB,da Silva Gomes R,Oliveira RJ

doi

10.1016/j.taap.2018.08.004

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

127-138

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(18)30360-0

journal_volume

356

pub_type

杂志文章

相关文献

TOXICOLOGY AND APPLIED PHARMACOLOGY文献大全
  • Developmentally-regulated sodium channel subunits are differentially sensitive to alpha-cyano containing pyrethroids.

    abstract：:Juvenile rats have been reported to be more sensitive to the acute neurotoxic effects of the pyrethroid deltamethrin than adults. While toxicokinetic differences between juveniles and adults are documented, toxicodynamic differences have not been examined. Voltage-gated sodium channels, the primary targets of pyrethro...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.04.017

    authors： Meacham CA,Brodfuehrer PD,Watkins JA,Shafer TJ

    更新日期：2008-09-15 00:00:00

  • MAPK pathway activation by chronic lead-exposure increases vascular reactivity through oxidative stress/cyclooxygenase-2-dependent pathways.

    abstract：:Chronic exposure to low lead concentration produces hypertension; however, the underlying mechanisms remain unclear. We analyzed the role of oxidative stress, cyclooxygenase-2-dependent pathways and MAPK in the vascular alterations induced by chronic lead exposure. Aortas from lead-treated Wistar rats (1st dose: 10 μg...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.01.005

    authors： Simões MR,Aguado A,Fiorim J,Silveira EA,Azevedo BF,Toscano CM,Zhenyukh O,Briones AM,Alonso MJ,Vassallo DV,Salaices M

    更新日期：2015-03-01 00:00:00

  • Acrolein generation stimulates hypercontraction in isolated human blood vessels.

    abstract：:Increased risk of vasospasm, a spontaneous hyperconstriction, is associated with atherosclerosis, cigarette smoking, and hypertension-all conditions involving oxidative stress, lipid peroxidation, and inflammation. To test the role of the lipid peroxidation- and inflammation-derived aldehyde, acrolein, in human vasosp...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2006.09.009

    authors： Conklin DJ,Bhatnagar A,Cowley HR,Johnson GH,Wiechmann RJ,Sayre LM,Trent MB,Boor PJ

    更新日期：2006-12-15 00:00:00

  • Studies with 1,1'-ethylidenebis(tryptophan), a contaminant associated with L-tryptophan implicated in the eosinophilia-myalgia syndrome.

    abstract：:L-Tryptophan binds to a rat liver nuclear envelope protein, and this binding is saturable, stereospecific, and of high affinity. Utilizing an in vitro assay of [3H]tryptophan binding to rat hepatic nuclear envelopes, we have previously determined that the L-tryptophan obtained from Showa Denko and which was implicated...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1994.1096

    authors： Sidransky H,Verney E,Cosgrove JW,Latham PS,Mayeno AN

    更新日期：1994-05-01 00:00:00

  • Lactational exposure and neonatal kinetics of methylmercury and inorganic mercury in mice.

    abstract：:The concentration of mercury in milk and the distribution pattern in the sucking pup was followed over time after administration of a single iv injection of 0.5 mg/kg body wt of 203Hg-labeled methylmercuric chloride or mercuric chloride to lactating mice on Day 10 of lactation. Mercury concentrations in milk of the da...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1998.8566

    authors： Sundberg J,Jönsson S,Karlsson MO,Oskarsson A

    更新日期：1999-01-15 00:00:00

  • Induction of metallothionein by steroids in rat primary hepatocyte cultures.

    abstract：:The purpose of this study was to characterize the induction of metallothionein (MT) by steroids in rat primary hepatocyte cultures. Comparison of the characteristics of MT induction by a steroid (dexamethasone) to that by metals (Zn and Cd), examination of the involvement of the glucocorticoid receptor in the steroid ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(87)90242-0

    authors： Bracken WM,Klaassen CD

    更新日期：1987-03-15 00:00:00

  • Impaired regulation of surfactant phospholipid metabolism in the isolated rat lung after nitrogen dioxide inhalation.

    abstract：:Various drugs have been shown to stimulate surfactant phospholipid metabolism. Particularly beta-adrenergic agonists play an important role under physiologic conditions. For the first time we have studied whether nitrogen dioxide (NO2) inhalation alters beta-adrenergic regulation of surfactant phospholipid metabolism ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1105

    authors： Mengel RG,Bernhard W,Barth P,von Wichert P,Müller B

    更新日期：1993-06-01 00:00:00

  • Disruption of inositol phosphate accumulation in cerebellar granule cells by polychlorinated biphenyls: a consequence of altered Ca2+ homeostasis.

    abstract：:The present study examined the activation of protein kinase C (PKC) and disruption of Ca2+ homeostasis as potential mechanisms underlying effects of the polychlorinated biphenyl (PCB) congener 2,2'-dichlorobiphenyl (DCB) on inositol phosphate (IP) signaling in cerebellar granule cells. DCB (100 microM) increased basal...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.0311

    authors： Shafer TJ,Mundy WR,Tilson HA,Kodavanti PR

    更新日期：1996-12-01 00:00:00

  • Role of 3,4-dichlorophenyl methyl sulfone, a metabolite of o-dichlorobenzene, in the changes in hepatic microsomal drug-metabolizing enzymes caused by o-dichlorobenzene administration in rats.

    abstract：:2,3- and 3,4-Dichlorophenyl methyl sulfoxides and 2,3- and 3,4-dichlorophenyl methyl sulfones (2,3- and 3,4-DCPSO2Mes) were detected in the urine of rats administered o-dichlorobenzene (o-DCB). After administration of o-DCB to rats, swift decreases were observed in the concentrations of o-DCB in blood, liver, and kidn...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1997.8191

    authors： Kato Y,Kimura R

    更新日期：1997-08-01 00:00:00

  • Differential effects of arsenic species on Nrf2 and Bach1 nuclear localization in cultured hepatocytes.

    abstract：:Arsenic is a ubiquitous metalloid element present in both inorganic and organic forms in the environment. The liver is considered to be a primary organ of arsenic biotransformation and methylation, as well as the main target of arsenic toxicity. Studies have confirmed that Chang human hepatocytes have an efficient ars...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2021.115404

    authors： Liu D,Xu G,Bai C,Gu Y,Wang D,Li B

    更新日期：2021-01-09 00:00:00

  • Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells.

    abstract：:Targeting excessive production of reactive oxygen species (ROS) could be an effective therapeutic strategy to prevent oxidative stress-associated gastrointestinal inflammation. NADPH oxidase (NOX) and mitochondrial complexes (I and II) are the major sources of ROS production contributing to TNF-α/cycloheximide (CHX)-i...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.07.007

    authors： Babu D,Leclercq G,Goossens V,Remijsen Q,Vandenabeele P,Motterlini R,Lefebvre RA

    更新日期：2015-10-15 00:00:00

  • Enhanced hepatic expression of P450IIE1 following inhalation exposure to pyridine.

    abstract：:Previous research has shown that intraperitoneal injection of the solvent pyridine results in a dose- and time-dependent induction of hepatic P450IIE1 in rats, with a twofold increase observed at 6 hr post-treatment. However, inhalation is the primary route of exposure expected for humans exposed to pyridine in labora...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1014

    authors： Hotchkiss JA,Kim SG,Novak RF,Dahl AR

    更新日期：1993-01-01 00:00:00

  • The natural toxin juglone causes degradation of p53 and induces rapid H2AX phosphorylation and cell death in human fibroblasts.

    abstract：:Juglone (5-hydroxy-1,4-naphtoquinone) is a natural toxin produced by walnut trees. In this study we show that juglone differentially reduces viability of human cells in culture. Normal fibroblast were found to be especially sensitive to juglone and lost viability primarily through a rapid apoptotic and necrotic respon...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2005.03.005

    authors： Paulsen MT,Ljungman M

    更新日期：2005-11-15 00:00:00

  • 4-Methoxyestradiol-induced oxidative injuries in human lung epithelial cells.

    abstract：:Epidemiological studies indicated that people exposed to dioxins were prone to the development of lung diseases including lung cancer. Animal studies demonstrated that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased liver tumors and promoted lung metaplasia in females. Metabolic changes in 17beta-estradiol (E(2))...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.01.024

    authors： Cheng Y,Chang LW,Cheng LC,Tsai MH,Lin P

    更新日期：2007-05-01 00:00:00

  • Induction of Fas receptor and Fas ligand by nodularin is mediated by NF-κB in HepG2 cells.

    abstract：:Nodularin is a natural toxin with multiple features, including inhibitor of protein phosphatases 1 and 2A as well as tumor initiator and promoter. One unique feature of nodularin is that this chemical is a hepatotoxin. It can accumulate into the liver after contact and lead to severe damage to hepatocyte, such as apop...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2011.01.009

    authors： Feng G,Li Y,Bai Y

    更新日期：2011-03-15 00:00:00

  • Bone marrow toxicity induced by oral benzo[a]pyrene: protection resides at the level of the intestine and liver.

    abstract：:The Ah locus encodes a cytosolic receptor that regulates the induction of certain drug-metabolizing enzymes by polycyclic aromatic hydrocarbons such as benzo[a]pyrene. Some inbred mouse strains such as C57BL/6N have the high-affinity Ah receptor (Ahb/Ahb), others such as DBA/2N, the poor-affinity receptor (Ahd/Ahd). P...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(83)90157-6

    authors： Legraverend C,Harrison DE,Ruscetti FW,Nebert DW

    更新日期：1983-09-30 00:00:00

  • Use of an optimized in vitro lymphocyte blastogenesis assay to detect contact sensitivity to nickel sulfate in mice.

    abstract：:This study was designed to determine whether an optimized in vitro lymphocyte blastogenesis assay for identification of strong contact sensitizers would also detect sensitization to the weaker, clinically relevant allergen nickel sulfate (NiSO4). Though NiSO4 is effective in eliciting allergic skin reactions in patien...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(90)90286-4

    authors： Robinson MK,Sneller DL

    更新日期：1990-06-01 00:00:00

  • Uptake, distribution, and elimination of carbon tetrachloride in rat tissues following inhalation and ingestion exposures.

    abstract：:Carbon tetrachloride (CCl4) has been studied extensively for its hepatotoxic effects. There is a paucity of information, however, about its tissue deposition following administration by different routes and patterns of exposure. The specific objective of this study was to delineate the uptake, distribution, and elimin...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.8079

    authors： Sanzgiri UY,Srivatsan V,Muralidhara S,Dallas CE,Bruckner JV

    更新日期：1997-03-01 00:00:00

  • Goniothalamin prevents the development of chemically induced and spontaneous colitis in rodents and induces apoptosis in the HT-29 human colon tumor cell line.

    abstract：:Colon cancer is the third most incident type of cancer worldwide. One of the most important risk factors for colon cancer development are inflammatory bowel diseases (IBD), thus therapies focusing on IBD treatment have great potential to be used in cancer prevention. Nature has been a source of new therapeutic and pre...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.03.009

    authors： Vendramini-Costa DB,Alcaide A,Pelizzaro-Rocha KJ,Talero E,Ávila-Román J,Garcia-Mauriño S,Pilli RA,de Carvalho JE,Motilva V

    更新日期：2016-06-01 00:00:00

  • Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity.

    abstract：:Emerging evidence suggests that feeding a high-fat diet (HFD) to rodents affects the expression of genes involved in drug transport. However, gender-specific effects of HFD on drug transport are not known. The multidrug resistance-associated protein 2 (Mrp2, Abcc2) is a transporter highly expressed in the hepatocyte c...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.04.001

    authors： Kong B,Csanaky IL,Aleksunes LM,Patni M,Chen Q,Ma X,Jaeschke H,Weir S,Broward M,Klaassen CD,Guo GL

    更新日期：2012-06-01 00:00:00

  • Regulation of UDP glucuronosyltransferases in the gastrointestinal tract.

    abstract：:The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic effects of lipophilic chemicals in the environment. UGTs such as UGT1A7, UGT1A8, and UGT1A10 are exclusively expressed in gastrointestinal tissues, each with a unique tissue distribution patter...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2004.01.008

    authors： Gregory PA,Lewinsky RH,Gardner-Stephen DA,Mackenzie PI

    更新日期：2004-09-15 00:00:00

  • 2,2',4,6,6'-pentachlorobiphenyl induces apoptosis in human monocytic cells.

    abstract：:Polychlorinatedbiphenyls (PCBs) are a group of persistent and widely dispersed environmental pollutants, some of which may be immunotoxic. In the present study, we investigated the effect of PCBs on immune system by assessing apoptotic cell death in human monocytic U937 cells. Among the various congeners tested, 2,2',...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.2000.9034

    authors： Shin KJ,Bae SS,Hwang YA,Seo JK,Ryu SH,Suh PG

    更新日期：2000-11-15 00:00:00

  • Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the ED01 study.

    abstract：:The development of tumors in relationship to 2-acetylaminofluorene (AAF) dose and time on study has been evaluated in an experiment conducted by the National Center for Toxicological Research (NCTR) using more than 24,000 female BALB/c mice. By using a biologically based model of two-event carcinogenesis accounting ex...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(90)90284-2

    authors： Cohen SM,Ellwein LB

    更新日期：1990-06-01 00:00:00

  • Influence of iron and zinc status on cadmium accumulation in Bangladeshi women.

    abstract：:Cadmium is a widespread environmental contaminant present in food. The absorption in the intestine increases in individuals with low iron stores, but the effect of zinc deficiency is not clear. The aim of the present study was to assess the influence of iron and zinc status on cadmium accumulation in pregnant Banglade...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.04.009

    authors： Kippler M,Ekström EC,Lönnerdal B,Goessler W,Akesson A,El Arifeen S,Persson LA,Vahter M

    更新日期：2007-07-15 00:00:00

  • Influence of the Ah locus on the humoral immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: evidence for Ah-receptor-dependent and Ah-receptor-independent mechanisms of immunosuppression.

    abstract：:There are conflicting reports in the literature regarding the role of the Ah locus in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity. The present studies have utilized two congenic strains of C57Bl/6 mice that differ only at this locus to assess its influence on TCDD-induced suppression of antibody response...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(90)90356-y

    authors： Kerkvliet NI,Steppan LB,Brauner JA,Deyo JA,Henderson MC,Tomar RS,Buhler DR

    更新日期：1990-08-01 00:00:00

  • Reversal of bropirimine developmental toxicity with progesterone.

    abstract：:Bropirimine is an immunomodulator with experimental antiviral and antitumor activities. This pyrimidinone has been found to be embryolethal at doses (200 and 400 mg/kg) that produce only transient maternal toxicity, when administered to pregnant Upj:TUC(SD)spf rats on specific days of gestation. Serum analyses carried...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(91)90275-j

    authors： Black DL,Marks TA,Branstetter DG,Kirton KT

    更新日期：1991-03-15 00:00:00

  • Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1.

    abstract：:The multidrug resistance (MDR) transporter is a phosphorylated glycoprotein (P-gp) that has been implicated in the efflux of a large variety of xenobiotics, thereby protecting vital organs. This study examines the hypothesis that the multidrug resistance transporter is involved in restricting the entry of polychlorina...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0041-008x(02)00069-8

    authors： Tampal NM,Robertson LW,Srinivasan C,Ludewig G

    更新日期：2003-03-15 00:00:00

  • Estimation and analysis of the concentration-response surfaces associated with multiple-agent combinations.

    abstract：:Chinese hamster cells (V79) were treated with ethylnitrosourea (ENU) and cis-diamminedichloroplatinum(II) (DDP) alone and in combination. Sister chromatid exchanges (SCEs) were quantified as measures of genotoxicity of the two agents. The combination experiment employed a factorial design in which cells were treated, ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(86)90117-1

    authors： Solana RP,Chinchilli VM,Wilson J,Carter WH Jr,Carchman RA

    更新日期：1986-09-15 00:00:00

  • Maternal-to-zygotic transition as a potential target for niclosamide during early embryogenesis.

    abstract：:Niclosamide is an antihelminthic drug used worldwide for the treatment of tapeworm infections. Recent drug repurposing screens have highlighted the broad bioactivity of niclosamide across diverse mechanisms of action. As a result, niclosamide is being evaluated for a range of alternative drug-repurposing applications,...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.114699

    authors： Vliet SMF,Dasgupta S,Sparks NRL,Kirkwood JS,Vollaro A,Hur M,Zur Nieden NI,Volz DC

    更新日期：2019-10-01 00:00:00

  • Proposed mechanistic description of dose-dependent BDE-47 urinary elimination in mice using a physiologically based pharmacokinetic model.

    abstract：:Polybrominated diphenyl ethers (PBDEs) have been used in a wide variety of consumer applications as additive flame retardants. In North America, scientists have noted continuing increases in the levels of PBDE congeners measured in human serum. Some recent studies have found that PBDEs are associated with adverse heal...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2013.09.007

    authors： Emond C,Sanders JM,Wikoff D,Birnbaum LS

    更新日期：2013-12-01 00:00:00