Vagal Nerve Stimulation: Indications for Revision in Adult Refractory Epilepsy.

Abstract:

OBJECTIVE:The goal of this study was to assess the indications of revision for vagal nerve stimulation at a single institution in an adult population with drug-resistant epilepsy. METHODS:This was a retrospective review of a prospectively collected database who underwent vagal nerve stimulator implantation for drug-resistant epilepsy during 1992-2017. Patients receiving vagal nerve stimulation (VNS) implants were monitored throughout their perioperative and postoperative course and were classified according to type of seizure at the time of diagnosis and indications for VNS revision. In addition, response to dysfunctional VNS devices or adverse effects were noted. RESULTS:Most patients receiving VNS implants were given a diagnosis of complex partial seizures (CPSs) before implantation (95.1%). Other epileptic conditions identified requiring implantation included generalized seizures, generalized-atonic seizures, Lennox-Gastaut syndrome, CPS or generalized seizures, and tuberous sclerosis (with generalized characteristics). High lead impedance was the most common indication for revision (5.6%), whereas device ineffectiveness leading to continued seizures was the most common indication for removal (2.3%). Infection, lead fracture, and dual- to single-pin lead battery changes occurred at an incidence of 1.9%, requiring either implant removal or revision. Other events that occurred, albeit rarely, included skin extrusion (0.5%), postoperative hematoma (0.5%), and implant rejection (0.5%) necessitating removal. CONCLUSIONS:VNS implantation in adults was shown to be a well-tolerated procedure. In addition, indications for revision or removal of the VNS device was low in this population with lead fracture rates lower than the incidence reported in pediatric population literature.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Gigliotti MJ,Mao G,Dupré DA,Wilberger J

doi

10.1016/j.wneu.2018.09.008

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

e1047-e1053

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(18)32028-X

journal_volume

120

pub_type

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