Abstract：
BACKGROUND:Atlantoaxial instability, a common finding in patients with Down syndrome (DS), is attributed to laxity of ligamentous structures. Cervical spondylosis identified in these patients has a pathogenesis of ligament laxity and early degeneration compared with the normal population. No cases have been reported showing affection of thoracic or lower levels. CASE DESCRIPTION:Two adults with DS presented with progressive spastic paraparesis with hypertrophy of ligamentum flavum at the lower thoracic level, causing canal stenosis and myelopathy. Degenerative changes were seen in the entire spine. Both patients improved with canal decompression. CONCLUSIONS:Degenerative changes of the spine occur earlier in DS, probably due to increased movements across the vertebrae owing to laxity in the ligaments. Routine workup of patients with DS presenting in their adult lives should keep in mind the affection of lower spinal levels. Early identification of thoracic myelopathy and lumbar canal stenosis gives a chance of cure.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Champaneri H,Banerjee ADdoi
10.1016/j.wneu.2020.07.040subject
Has Abstractpub_date
2020-10-01 00:00:00pages
325-327eissn
1878-8750issn
1878-8769pii
S1878-8750(20)31551-5journal_volume
142pub_type
abstract：BACKGROUND:Osteoid osteomas (OOs) are benign bone forming tumors that, usually, occur in the extremities, with about 10% of them arising in the spine more commonly in the posterior elements. The aim of this study is to evaluate the long-term results of patients suffering from spinal OO treated with surgery and radiofre...
journal_title：World neurosurgery
pub_type： 杂志文章
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更新日期：2021-01-01 00:00:00
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journal_title：World neurosurgery
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更新日期：2020-12-01 00:00:00
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journal_title：World neurosurgery
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更新日期：2017-12-01 00:00:00
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更新日期：2018-08-01 00:00:00
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journal_title：World neurosurgery
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journal_title：World neurosurgery
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journal_title：World neurosurgery
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更新日期：2014-11-01 00:00:00
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更新日期：2019-06-01 00:00:00
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journal_title：World neurosurgery
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更新日期：2018-10-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.06.182
更新日期：2018-09-01 00:00:00
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journal_title：World neurosurgery
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doi：10.1016/j.wneu.2017.04.105
更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2016.05.076
更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2019.06.159
更新日期：2019-09-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.02.027
更新日期：2018-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.036
更新日期：2019-07-01 00:00:00
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更新日期：2020-06-01 00:00:00
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更新日期：2020-12-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2016-07-01 00:00:00
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更新日期：2019-06-01 00:00:00
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更新日期：2020-06-01 00:00:00
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更新日期：2020-11-26 00:00:00
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更新日期：2010-02-01 00:00:00
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更新日期：2020-09-01 00:00:00
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更新日期：2020-02-01 00:00:00
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journal_title：World neurosurgery
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