Abstract：
OBJECTIVE:To analyze the clinical characteristics, immunohistochemistry, and treatment outcomes for skull base chordomas and the correlation between extent of resection/pathology type and outcomes. METHODS:The clinical materials of 77 consecutive patients with skull base chordomas were analyzed retrospectively. Follow-up data were available in 66 patients, ranging from 6 to 142 months (mean, 59.6 months). Outcome in survival was assessed by the overall survival (OS) and progression-free survival (PFS). Outcome in function was evaluated by Karnofsky performance score. RESULTS:Total or near-total tumor resection was achieved in 25 cases (32.5%), subtotal in 32 cases (47.6%), and partial resection in 9 cases (11.7%). Gamma knife radiosurgery was used in 22 patients (33.3%). Forty-two of the 77 patients had immunohistochemistry results and the rates of positive staining for cytokeratin, epithelial membrane antigen, vimentin, S-100 were 100%, 92.9%, 83.3%, and 88.1%, respectively. The PFS rates at 3, 5, and 8 years were 82.6%, 45.0%, and 18.2%, respectively. The OS rates at 3, 5, and 8 years were 89.2%, 70.9%, and 45.5 %, respectively. Less tumor resection and dedifferentiated pathology were risk factors for worse OS and PFS (P < 0.05). Among the 43 currently surviving patients, the mean Karnofsky performance score before the surgery and at the last follow-up were 87.3 and 82.4, respectively. CONCLUSIONS:Aggressive surgical resection should be performed for skull base chordomas, considering certain postoperative functional status. Immunohistochemical study is helpful in differential diagnosis. The combination of aggressive surgical resection and gamma knife radiosurgery for skull base chordomas may obtain favorable outcomes.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Ouyang T,Zhang N,Zhang Y,Jiao J,Ren J,Huang T,Chen Jdoi
10.1016/j.wneu.2013.01.010subject
Has Abstractpub_date
2014-05-01 00:00:00pages
790-7issue
5-6eissn
1878-8750issn
1878-8769pii
S1878-8750(13)00017-Xjournal_volume
81pub_type
杂志文章abstract：OBJECTIVE:Preoperative embolization may facilitate skull base meningioma resection, but its safety and efficacy in the Onyx era have not been investigated. In this retrospective cohort study, we evaluated the outcomes of preoperative embolization of skull base meningiomas using Onyx as the primary embolysate. METHODS:...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.208
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:Prognostic factors of favorable and unfavorable clinical outcome after aneurysmal subarachnoid hemorrhage (SAH) are still not completely known. We retrospectively analyzed the aneurysm location as a factor for patients' outcome after aneurysmal SAH. METHODS:We retrospectively selected patients from our prosp...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.04.086
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Vagus nerve stimulation (VNS) has become an increasingly popular procedure for the treatment of epilepsy and depression. Significant complications or side effects associated with VNS surgery may result from either the inadvertent direct injury to the vagus nerve as part of the surgical approach, placement of...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.08.014
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:The present study examined the physical extent of Modic type 1 (MT1) changes and other phenotypic magnetic resonance imaging (MRI) findings in the vertebrae of patients with low back pain (LBP) and MT1 changes. We also identified any correlations of these findings with the severity of pain and the Oswestry Di...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.09.132
更新日期：2019-01-01 00:00:00
abstract：:Rare anomalous courses of vertebral arteries in the craniovertebral junction may compress the spinal cord causing myelopathy. We report here the severest form of this pathologic condition successfully treated with transposition of bilateral vertebral artery using Gore-Tex tapes. A 73-year-old man presented with progre...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.10.050
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:With the continuous advancement of the spinal endoscopic technique in recent years, full-endoscopic operations provide a new approach for the treatment of migrated cervical disk herniation. CASE DESCRIPTION:A 42-year-old man presented with nuchal pain and limb numbness for 2 months, with recently developed ...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2019.08.054
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to assess the radiologic and clinical outcomes after lumbar fusion intervention and to compare the established posterior lumbar interbody fusion (PLIF) technique and dynamic hybrid instrumentation (topping off). METHODS:In this prospective randomized trial, all patients who pres...
journal_title：World neurosurgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.wneu.2018.06.005
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Tuberculous meningitis (TBM) is an endemic infectious disease in developing countries, and it can become a serious illness in children. Treatment of TBM is more difficult and prone to failure than treatment of pulmonary tuberculosis. TBM causes hydrocephalus, cerebral edema, increased intracranial pressure, ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.12.007
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Indocyanine green videoangiography (ICG-VA) after clipping can be misleading in evaluating aneurysm exclusion when the dye is injected before clipping. This is due to indocyanine green (ICG) entrapment by the clip blades in the aneurysm dome. METHODS:We examined the intraoperative findings of 7 patients pre...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.10.011
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Intracranial mycotic aneurysms are uncommon. They can occur due to extravascular extension or intravascular seeding of the vessel wall. They often result in subarachnoid hemorrhage with poor prognosis. We present a rare case of subarachnoid hemorrhage due to vertebral artery dissection with aproximal anterio...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.06.090
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) has been a major advance in the treatment of dystonias. Outcomes are, however, less predictable for secondary dystonias, predominantly due to progression of disease or specific brain lesions. There are few cases reported of globus pallidus internus (GPi)-DBS for posttraumatic dys...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.05.014
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Unfavorable anatomy can preclude traditional anterograde endovascular interventions. Transcirculation approaches, which consist of primary catheterization of a target artery from the contralateral side or opposite cerebral circulation, can provide alternative pathways for successful treatment of these patien...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2019.11.078
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:Academic metrics can be used to compare the productivity of researchers. We aimed to use a variety of bibliometric parameters to assess the productivity of neurosurgeons working in the United Kingdom. METHODS:Neurosurgical consultants working in the United Kingdom were identified using the Society of Britis...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.09.041
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Spinal cord herniation (SCH) is rare, is mostly idiopathic, and occurs predominantly in the thoracic spine. SCH is less common in the cervical spine and has been reported after posterior cervical spine surgery associated with the development of pseudomeningoceles. Two cases of SCH have been reported after an...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.01.078
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy of the combined use of a gasket seal closure and a vascularized pedicle nasoseptal flap (VP-NSF) multilayered reconstruction technique for high-flow cerebrospinal fluid (CSF) leaks resulting from endonasal endoscopic skull base surgery. METHODS:From October 2009-June 2011, a VP-NSF mul...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2014.06.004
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:Intracranial psammomatous meningiomas (PMs) are rarely reported due to their extremely low incidence. Knowledge about intracranial PMs is therefore poor. This study aimed to analyze the incidence, clinical features, radiologic findings, and surgical outcomes of intracranial PMs. METHODS:Approximately 5651 in...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.01.056
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:Craniopharyngiomas have traditionally represented a challenge for open transcranial or transsphenoidal microscopic neurosurgery because of their anatomical location and proximity to vital neurovascular structures. The extended endoscopic endonasal transsphenoidal approach has been more recently developed as a...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2011.07.011
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:To compare the treatment results between 1-level vertebral column decancellation (VCD) and pedicle subtraction osteotomy (PSO) for correcting severe kyphotic deformity in ankylosing spondylitis (AS). VCD and PSO have been used to correct AS-related kyphotic deformity, but the differences on correcting results...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.011
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:The decision between conservative management and invasive treatment of juxtaorbital intracranial vascular anomalies can be challenging. Whereas arteriovenous malformations (AVMs) can lead to vision loss and are potentially life-threatening if they rupture, invasive endovascular and surgical procedures also c...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2013.01.093
更新日期：2014-07-01 00:00:00
abstract：:We present an uncommon case of holocord, "rosary bead-like," multiloculated syringomyelia consistent with a fourth ventricle outlet obstruction in a 2-month-old infant who was previously shunted for posthemorrhagic hydrocephalus of prematurity. The shunt malfunction resulted in a syringomyelia because of the simultane...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.04.158
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:Large schwannomas with intradural and extradural extensions are often challenging surgical lesions. A variety of approaches, usually requiring large exposures, removal of facets and pars interarticularis, and spinal stabilization, have been described. The aim of this study is to describe the "dual approach," ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.07.103
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Hydrocephalus secondary to spinal cord tumors is rare. CASE DESCRIPTION:We present a 39-year-old male with gradual-onset headache whose initial diagnosis was cerebral aneurysm and communicating hydrocephalus. The correct diagnosis was primary intradural extramedullary malignant melanoma of the spinal cord. ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.07.046
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Ankylosing spondylitis (AS) is an inflammatory disease that involves above all the spine and the pelvis. In the spine, the inflammatory processes cause the formation of syndesmophytes between the vertebral bodies and the ossification of ligaments, with bony overgrowth. In this setting, dysphagia is a rare bu...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2020.04.031
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:To investigate the noninferiority of facet joint- and nuchal ligament-sparing laminectomy (FNL) compared with conventional open-door laminoplasty. METHODS:This retrospective study analyzed 31 patients who underwent FNL (7 women; median age, 71 years) and 29 patients who underwent laminoplasty (9 women; media...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.01.187
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Multiple sclerosis (MS) is a common autoimmune and neurodegenerative disease of the central nervous system characterized by inflammatory demyelination, axonal degeneration, and neuronal loss. The exact pathogenesis of MS remains uncertain; however, studies have shown that the development of MS is influenced ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.04.027
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Cerebral vasospasm is an important cause of morbidity after subarachnoid hemorrhage, but can also occur after resection of acoustic neuroma. This study aimed to identify factors associated with postoperative cerebral vasospasm in patients with acoustic neuroma. METHODS:This was a retrospective analysis of p...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.07.016
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Aneurysms of the extracranial vertebral artery are rare, and the treatment options are not standardized. We present a case of an extracranial vertebral artery aneurysm treated with flow diversion. CASE DESCRIPTION:In a 72-year-old woman, computed tomography angiography demonstrated a right extracranial vert...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.03.064
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Intracranial extraskeletal mesenchymal chondrosarcomas (MCSs) are rare tumors accounting for <0.16% of intracranial tumors. They are usually described as occurring in the age group of 20-30 years and are commonly found in the frontoparietal region arising from the falx and surrounding dura. We describe 3 cas...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.08.049
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:To elucidate the efficacy of dorsal root ganglion stimulation in the treatment of chronic neuropathic pain confined to the knee. METHODS:Retrospective analysis of prospectively collected data of 14 consecutive patients undergoing dorsal root ganglion stimulation for chronic knee pain, in a single center. Th...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.07.102
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:The laterocavernous sinus system is best defined as the entire territory served by the laterocavernous and the superior petrosal sinuses (SPS). METHODS:The laterocavernous sinus is a small but important venous structure located between the two dural layers forming the lateral wall of the cavernous sinus and...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2010.09.016
更新日期：2011-01-01 00:00:00
