Abstract:
:Outer membrane vesicles (OMVs) play an important role in the persistence of Helicobacter pylori infection. Helicobacter OMVs carry a plethora of virulence factors, including catalase (KatA), an antioxidant enzyme that counteracts the host respiratory burst. We found KatA to be enriched and surface-associated in OMVs compared to bacterial cells. This conferred OMV-dependent KatA activity resulting in neutralization of H2O2 and NaClO, and rescue of surrounding bacteria from oxidative damage. The antioxidant activity of OMVs was abolished by deletion of KatA. In conclusion, enrichment of antioxidative KatA in OMVs is highly important for efficient immune evasion.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Lekmeechai S,Su YC,Brant M,Alvarado-Kristensson M,Vallström A,Obi I,Arnqvist A,Riesbeck Kdoi
10.3389/fmicb.2018.01837subject
Has Abstractpub_date
2018-09-07 00:00:00pages
1837issn
1664-302Xjournal_volume
9pub_type
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