Helicobacter pylori Outer Membrane Vesicles Protect the Pathogen From Reactive Oxygen Species of the Respiratory Burst.

Abstract:

:Outer membrane vesicles (OMVs) play an important role in the persistence of Helicobacter pylori infection. Helicobacter OMVs carry a plethora of virulence factors, including catalase (KatA), an antioxidant enzyme that counteracts the host respiratory burst. We found KatA to be enriched and surface-associated in OMVs compared to bacterial cells. This conferred OMV-dependent KatA activity resulting in neutralization of H2O2 and NaClO, and rescue of surrounding bacteria from oxidative damage. The antioxidant activity of OMVs was abolished by deletion of KatA. In conclusion, enrichment of antioxidative KatA in OMVs is highly important for efficient immune evasion.

journal_name

Front Microbiol

authors

Lekmeechai S,Su YC,Brant M,Alvarado-Kristensson M,Vallström A,Obi I,Arnqvist A,Riesbeck K

doi

10.3389/fmicb.2018.01837

subject

Has Abstract

pub_date

2018-09-07 00:00:00

pages

1837

issn

1664-302X

journal_volume

9

pub_type

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