Prognostic impact of combining whole-body PET/CT and brain PET/MR in patients with lung adenocarcinoma and brain metastases.

abstract：PURPOSE:Anti-PD-1/PD-L1 blockade can restore tumour-specific T-cell immunity and is an emerging therapy in non-small-cell lung cancer (NSCLC). We investigated the correlation between 18F-FDG PET/CT-based markers and tumour tissue expression of PD-L1, necrosis and clinical outcome in patients receiving checkpoint inhibi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Jreige M,Letovanec I,Chaba K,Renaud S,Rusakiewicz S,Cristina V,Peters S,Krueger T,de Leval L,Kandalaft LE,Nicod-Lalonde M,Romero P,Prior JO,Coukos G,Schaefer N

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:The study serves to optimise conditions for multi-pinhole SPECT small animal imaging of (123)I- and (99m)Tc-labelled radiopharmaceuticals with different distributions in murine heart and brain and to investigate detection and dose range thresholds for verification of differences in tracer uptake. METHODS:A Tri...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Pissarek M,Meyer-Kirchrath J,Hohlfeld T,Vollmar S,Oros-Peusquens AM,Flögel U,Jacoby C,Krügel U,Schramm N

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:The aim of the study was to assess the role of myocardial perfusion scintigraphy (MPS) in the prediction of future cardiac events in elderly hypertensive patients and to investigate if its prognostic value is maintained during a 10-year follow-up period. METHODS:A total of 229 consecutive patients ≥ 65 years o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nai Fovino L,Saladini G,Cervino AR,Saladini F,Gregianin M,Razzolini R,Evangelista L

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:Ischemia in hypertrophic cardiomyopathy (HCM) is caused by coronary microvascular dysfunction (CMD), which is detected by measuring myocardial blood flow (MBF) with PET. Whether CMD may be associated with ischemic left ventricular (LV) dysfunction is unclear. We therefore assessed LV ejection fraction (EF)...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sciagrà R,Calabretta R,Cipollini F,Passeri A,Castello A,Cecchi F,Olivotto I,Pupi A

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:It has been shown that some primary human tumours and their metastases, including prostate and breast tumours, overexpress gastrin-releasing peptide (GRP) receptors. Bombesin (BN) is a neuropeptide with a high affinity for these GRP receptors. We demonstrated successful scintigraphic visualisation of BN recepto...

journal_title：European journal of nuclear medicine and molecular imaging

authors： de Visser M,Bernard HF,Erion JL,Schmidt MA,Srinivasan A,Waser B,Reubi JC,Krenning EP,de Jong M

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:The specific binding ratio (SBR) of 123I-FP-CIT (FP-CIT) in the putamen decreases with age by about 5% per decade and most likely is about 10% higher in females. However, the clinical utility of age and sex correction of the SBR is still a matter of debate. This study tested the impact of age and sex correction...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schmitz-Steinkrüger H,Lange C,Apostolova I,Mathies FL,Frings L,Klutmann S,Hellwig S,Meyer PT,Buchert R

更新日期：2020-10-31 00:00:00

abstract：:Nuclear medicine has a central role in the diagnosis, staging, response assessment and long-term follow-up of neuroblastoma, the most common solid extracranial tumour in children. These EANM guidelines include updated information on 123I-mIBG, the most common study in nuclear medicine for the evaluation of neuroblasto...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bar-Sever Z,Biassoni L,Shulkin B,Kong G,Hofman MS,Lopci E,Manea I,Koziorowski J,Castellani R,Boubaker A,Lambert B,Pfluger T,Nadel H,Sharp S,Giammarile F

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans. METHODS:PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 mo...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Scott AM,Gunawardana DH,Wong J,Kirkwood I,Hicks RJ,Ho Shon I,Ramshaw JE,Robins P

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:(131)Iodine metaiodobenzylguanidine ((131)I-MIBG) is a radiopharmaceutical used for scintigraphic localisation of phaeochromocytomas and paragangliomas. The experience with its therapeutic use is limited. We report our experience for the treatment of malignant phaeochromocytoma and paraganglioma. MATERIALS AND...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Gedik GK,Hoefnagel CA,Bais E,Olmos RA

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) has been widely utilized in the study of traumatic brain injury (TBI) for decades. While most applications of PET have attempted to assess neuronal function after TBI, more recently, novel radiotracers have sought to image biomarkers in the context of TBI and chronic traumatic...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ayubcha C,Revheim ME,Newberg A,Moghbel M,Rojulpote C,Werner TJ,Alavi A

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:The folate receptor (FR) is frequently overexpressed in a variety of tumor types and, hence, an interesting target for radionuclide therapy. The aim of this study was to evaluate a new class of albumin-binding radioconjugates comprising 5-methyltetrahydrofolate (5-MTHF) as a targeting agent and to compare their...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Guzik P,Benešová M,Ratz M,Monné Rodríguez JM,Deberle LM,Schibli R,Müller C

更新日期：2020-10-15 00:00:00

abstract：PURPOSE:Both head and neck magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) play a crucial role in the staging of primary nasopharyngeal carcinoma (NPC). In this study, we sought to prospectively investigate the clinical utility of simulta...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Chan SC,Yeh CH,Yen TC,Ng SH,Chang JT,Lin CY,Yen-Ming T,Fan KH,Huang BS,Hsu CL,Chang KP,Wang HM,Liao CT

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the usefulness of L-4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) as a tumor-specific probe, in comparison to 18F-FDG and 11C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Watabe T,Ikeda H,Nagamori S,Wiriyasermkul P,Tanaka Y,Naka S,Kanai Y,Hagiwara K,Aoki M,Shimosegawa E,Kanai Y,Hatazawa J

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is increasingly used to evaluate treatment response in head and neck squamous cell carcinoma (HNSCC). This analysis assessed the diagnostic value of FDG-PET/CT in detecting nodal disease within 6 months after treat...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Helsen N,Van den Wyngaert T,Carp L,Stroobants S

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Radiolabelled meta-iodobenzylguanidine (mIBG), used as targeted therapy for neuroblastoma, is known to have effects on blood pressure (BP). In this study we audited BP changes in patients receiving (131)I-mIBG therapy for neuroblastoma to identify BP-related adverse events (AE) and possible predictive factors. ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kosmin MA,Bomanji JB,Cork NJ,Shankar A,Gaze MN

更新日期：2012-04-01 00:00:00

abstract：:Primary treatment of differentiated thyroid carcinoma consists of total thyroidectomy followed by ablation of thyroid tissue remnants and possible metastases by means of radioactive iodine. After complete destruction of remnants, metastases or recurrence can be detected by measurement of the serum thyroglobulin level ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： de Geus-Oei LF,Oei HY,Hennemann G,Krenning EP

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:To determine the impact on clinical management of patients with high-risk (HR) prostate cancer at diagnosis and patients with biochemical recurrence (BCR) using a new kit form of 68Ga-prostate-specific membrane antigen (PSMA), namely tris(hydroxypyridinone) (THP)-PSMA, with positron emission tomography-computed...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kulkarni M,Hughes S,Mallia A,Gibson V,Young J,Aggarwal A,Morris S,Challacombe B,Popert R,Brown C,Cathcart P,Dasgupta P,Warbey VS,Cook GJR

更新日期：2020-03-01 00:00:00

abstract：INTRODUCTION:Tumor hypoxia is a centerpiece of disease progression mechanisms such as neoangiogenesis or aggressive hypoxia-resistant malignant cells selection that impacts on radiotherapy strategies. Early identification of regions at risk for recurrence and prognostic-based classification of patients is a necessity t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Leimgruber A,Hickson K,Lee ST,Gan HK,Cher LM,Sachinidis JI,O'Keefe GJ,Scott AM

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Bone metastases are responsible for most of the morbidity associated with hormone-refractory prostate cancer (HRPC). 153Sm-ethylenediaminetetramethylene phosphonate (153Sm-EDTMP) has been approved for palliation of painful skeletal metastases. We retrospectively investigated the possible synergistic effect o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ricci S,Boni G,Pastina I,Genovesi D,Cianci C,Chiacchio S,Orlandini C,Grosso M,Alsharif A,Chioni A,Di Donato S,Francesca F,Selli C,Rubello D,Mariani G

更新日期：2007-07-01 00:00:00

abstract：:This study was performed to assess the potential benefit of positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (FDG) in patients with cervical metastasis of squamous cell carcinoma from an unknown primary tumour. Eighteen patients with cervical metastasis of squamous cell carcinoma from an unknown...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Stoeckli SJ,Mosna-Firlejczyk K,Goerres GW

更新日期：2003-03-01 00:00:00

abstract：:This paper updates the information on the prevalence of the disorders induced by iodine deficiency (IDD) in Europe. Thirty-two European countries were still affected by mild to severe iodine deficiency in the late 1990s. The most severely affected countries were in Eastern Europe, including Central Asia, but Western E...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Delange F

更新日期：2002-08-01 00:00:00

abstract：:We assessed the accuracy of brain perfusion single-photon emission computed tomography (SPECT) in discriminating between patients with probable Alzheimer's disease (AD) at the very early stage and age-matched controls before and after partial volume correction (PVC). Three-dimensional MRI was used for PVC. We randomly...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kanetaka H,Matsuda H,Asada T,Ohnishi T,Yamashita F,Imabayashi E,Tanaka F,Nakano S,Takasaki M

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:Carimas (Cardiac Image Analysis System) is a new software package developed at the Turku PET Centre for the quantitation of PET studies of the heart with a broad range of tracers. The goal of this study was to assess the reproducibility of results the package provides for myocardial perfusion (MP) quantitation ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nesterov SV,Han C,Mäki M,Kajander S,Naum AG,Helenius H,Lisinen I,Ukkonen H,Pietilä M,Joutsiniemi E,Knuuti J

更新日期：2009-10-01 00:00:00

abstract：RATIONALE:In Parkinson's disease (PD), spatial covariance analysis of 18F-FDG PET data has consistently revealed a characteristic PD-related brain pattern (PDRP). By quantifying PDRP expression on a scan-by-scan basis, this technique allows objective assessment of disease activity in individual subjects. We provide a f...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Meles SK,Renken RJ,Pagani M,Teune LK,Arnaldi D,Morbelli S,Nobili F,van Laar T,Obeso JA,Rodríguez-Oroz MC,Leenders KL

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:We investigated the performance of the Inveon small-animal PET/SPECT/CT system and compared the imaging capabilities of the SPECT and PET components. METHODS:For SPECT, the energy resolution, tomographic spatial resolution and system sensitivity were evaluated with a (99m)Tc solution using a single pinhole col...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Magota K,Kubo N,Kuge Y,Nishijima K,Zhao S,Tamaki N

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:To examine the diagnostic sensitivity and specificity of dopamine transporter SPECT imaging with a highly dopamine transporter selective radioligand. The study included consecutively enrolled, drug-naive patients with an average short history of parkinsonian motor symptoms, referred for diagnostic scanning. ME...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ziebell M,Andersen BB,Thomsen G,Pinborg LH,Karlsborg M,Hasselbalch SG,Knudsen GM

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:Dual-isotope simultaneous acquisition single-photon emission computed tomography (DISA SPECT) with 18F-fluorodeoxyglucose (FDG) and (99m)Tc-sestamibi appears attractive for the detection of viable myocardium because it permits simultaneous assessment of glucose utilisation and perfusion. Another potential benef...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Matsunari I,Kanayama S,Yoneyama T,Matsudaira M,Nakajima K,Taki J,Nekolla SG,Tonami N,Hisada K

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:Diagnostic imaging modalities have moderate sensitivity for the identification of lymph node (LN) metastases in prostate cancer (PCa) patients. Mapping the lymphatic drainage from the prostate can help to identify the LNs directly draining from the tumour (sentinel nodes (SNs)); the LNs stated to have the highe...

journal_title：European journal of nuclear medicine and molecular imaging

authors： de Korne CM,Wit EM,de Jong J,Valdés Olmos RA,Buckle T,van Leeuwen FWB,van der Poel HG

更新日期：2019-11-01 00:00:00

abstract：INTRODUCTION:Fluorescence guidance is an upcoming methodology to improve surgical accuracy. Challenging herein is the identification of the minimum dose at which the tracer can be detected with a clinical-grade fluorescence camera. Using a hybrid tracer such as indocyanine green (ICG)-(99m)Tc-nanocolloid, it has become...

journal_title：European journal of nuclear medicine and molecular imaging

authors： KleinJan GH,Bunschoten A,van den Berg NS,Olmos RA,Klop WM,Horenblas S,van der Poel HG,Wester HJ,van Leeuwen FW

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Hypometabolism of the posterior cingulate cortex (PCC) in early Alzheimer's disease (AD) is thought to arise in part due to AD-specific neuronal damage to the hippocampal formation. Here, we explored the association between microstructural alterations within the hippocampus and whole-brain glucose metabolism in...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yakushev I,Schreckenberger M,Müller MJ,Schermuly I,Cumming P,Stoeter P,Gerhard A,Fellgiebel A

更新日期：2011-12-01 00:00:00