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TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides.

Abstract：

:TAR DNA binding protein 43 (TDP-43) is a key target in amyotrophic lateral sclerosis (ALS) treatment. Here, based on hydrophobic tagging strategy, we designed and synthesized a series of single or double hydrophobic tags conjugated peptides D1-D8. Among them, it was found that D4 displayed strongest ability to induce TDP-43 degradation in cells. D4 could reduce TDP-43 induced cytotoxicity. Besides, D4 could reduce TDP-43 levels in a transgenic drosophila model.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Gao N,Huang YP,Chu TT,Li QQ,Zhou B,Chen YX,Zhao YF,Li YM

doi

10.1016/j.bioorg.2018.11.042

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

254-259

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(18)30704-1

journal_volume

84

pub_type

杂志文章

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