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Disease progression impacts health-related quality of life in amyotrophic lateral sclerosis.

Abstract：

OBJECTIVES:To determine the impact of disease progression on health-related quality of life in amyotrophic lateral sclerosis (ALS). METHODS:A total of 161 patients with ALS were enrolled. Assessments included the revised ALS Functional Rating Scale and the ALS Assessment Questionnaire (ALSAQ-40). Data analysis comprised linear regression and multivariate analyses. RESULTS:ALSFRS-R score (β = 0.75, p < 0.001), depression (β = 0.08, p < 0.001), pain (β = 0.07, p < 0.001), hopelessness (β = 0.07, p = 0.001), and progression rate (β = 0.02, p = 0.02) explained 76% of the ALSAQ-40 summary index variance. Progression rate alone explained 7% of the ALSAQ-40 summary index variance. The subdomains of emotional well-being, followed by ADL, and finally communication and eating were most strongly influenced by progression rate. CONCLUSION:Our study demonstrates the importance of physical health for emotional well-being. In particular, slower disease progression is associated with higher levels of emotional well-being in ALS.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Prell T,Gaur N,Stubendorff B,Rödiger A,Witte OW,Grosskreutz J

doi

10.1016/j.jns.2018.12.035

subject

Has Abstract

pub_date

2019-02-15 00:00:00

pages

92-95

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(18)30530-6

journal_volume

397

pub_type

杂志文章

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