Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease.

abstract：:Mechanisms underlying hypertensive target organ damage (TOD) are not completely understood. The pathophysiological role of mitochondrial oxidative stress, resulting from mitochondrial dysfunction, in development of TOD is unclear. The stroke-prone spontaneously hypertensive rat (SHRSP) is a suitable model of human hyp...

journal_title：Oxidative medicine and cellular longevity

authors： Rubattu S,Stanzione R,Volpe M

更新日期：2016-01-01 00:00:00

abstract：:Due to the high biotolerance, favourable mechanical properties, and osseointegration ability, titanium is the basic biomaterial used in maxillofacial surgery. The passive layer of titanium dioxide on the surface of the implant effectively provides anticorrosive properties, but it can be damaged, resulting in the relea...

journal_title：Oxidative medicine and cellular longevity

authors： Borys J,Maciejczyk M,Antonowicz B,Krętowski A,Waszkiel D,Bortnik P,Czarniecka-Bargłowska K,Kocisz M,Szulimowska J,Czajkowski M,Waszkiewicz N,Zalewska A

更新日期：2018-06-14 00:00:00

abstract：:Hemolytic diseases are characterized by an accelerated breakdown of red blood cells (RBCs) and the release of hemoglobin (Hb). Following, RBC lysis Hb oxidation occurs with the formation of different redox states of Hb (metHb and ferrylHb) and the release of heme. ferrylHb is unstable and decomposes to metHb with the ...

journal_title：Oxidative medicine and cellular longevity

authors： Nyakundi BB,Erdei J,Tóth A,Balogh E,Nagy A,Nagy B Jr,Novák L,Bognár L,Paragh G,Kappelmayer J,Jeney V

更新日期：2020-04-25 00:00:00

abstract：:Reversible myocardial ischemia/reperfusion (I/R) or ischemic preconditioning (IPC) is associated with an immediate genomic response; IPC-induced immediate early genes are associated with reduced infarct size. Because the immediate early response gene X-1 (IEX-1) plays a central role in cell apoptosis, we examine wheth...

journal_title：Oxidative medicine and cellular longevity

authors： Xu MJ,Cai Y,Qu A,Shyy JY,Li W,Wang X

更新日期：2017-01-01 00:00:00

abstract：Background:The mechanisms of crosstalk between depression and gastric cancer (GC) remain ill defined. Given that reactive oxygen species (ROS) is involved in the pathophysiology of both GC and depression, we try to explore the activities of ROS in the development of GC and GC-related depression. Methods:110 patients w...

journal_title：Oxidative medicine and cellular longevity

authors： Huang T,Zhou F,Yuan X,Yang T,Liang X,Wang Y,Tu H,Chang J,Nan K,Wei Y

更新日期：2019-07-15 00:00:00

abstract：:Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks...

journal_title：Oxidative medicine and cellular longevity

authors： Othman MS,Fareid MA,Abdel Hameed RS,Abdel Moneim AE

更新日期：2020-10-19 00:00:00

abstract：:Bushen Tiansui Formula (BSTSF) is a traditional Chinese medicine prescription. It has been widely applied to treat Alzheimer's disease (AD) in the clinic; however, the mechanisms underlying its effects remain largely unknown. In this study, we used a rat AD model to study the effects of BSTSF on cognitive performance,...

journal_title：Oxidative medicine and cellular longevity

authors： Yi M,Zhang C,Zhang Z,Yi P,Xu P,Huang J,Peng W

更新日期：2020-06-19 00:00:00

abstract：:This study aims at investigating the radioprotective effect of ethanol extract from Ji-Xue-Teng (JXT, Spatholobus suberectus) on radiation-induced hematopoietic alteration and oxidative stress in the liver. Mice were exposed to a single acute γ-radiation for the whole body at the dose of 6.0 Gy, then subjected to admi...

journal_title：Oxidative medicine and cellular longevity

authors： Dong XZ,Wang YN,Tan X,Liu P,Guo DH,Yan C

更新日期：2018-10-28 00:00:00

abstract：:In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion. Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function. This is associated with elevated ROS production from overstimulated mitochondria. Mitochondria ar...

journal_title：Oxidative medicine and cellular longevity

authors： Li N,Stojanovski S,Maechler P

更新日期：2012-01-01 00:00:00

abstract：Objectives:Our previous study showed that aldose reductase (AR) played key roles in fatty liver ischemia-reperfusion (IR) injury by regulating inflammatory response and energy metabolism. Here, we aim to investigate the role and mechanism of AR in the regeneration of normal and fatty livers after liver surgery. Method...

journal_title：Oxidative medicine and cellular longevity

authors： Li CX,Wang HW,Jiang WJ,Li GC,Zhang YD,Luo CH,Li XC

更新日期：2020-02-27 00:00:00

abstract：:Exercise induced skeletal muscle phenotype change involves a complex interplay between signaling pathways and downstream regulators. This study aims to investigate the effect of acute exercise on mitochondrial H2O2 production and its association with p(66Shc), FOXO3a, and antioxidant enzymes. Male ICR/CD-1 mice were s...

journal_title：Oxidative medicine and cellular longevity

authors： Wang P,Li CG,Qi Z,Cui D,Ding S

更新日期：2015-01-01 00:00:00

abstract：:Bisphenol A (BPA) and its analogues (BPs) are suspected posing potential endocrine disrupting properties. They might migrate into foodstuffs through food packaging materials or contaminated water and soil. Dietary exposure is of paramount importance way for human health. European Food Safety Authority (EFSA) lowered t...

journal_title：Oxidative medicine and cellular longevity

authors： Yao K,Zhang J,Yin J,Zhao Y,Shen J,Jiang H,Shao B

更新日期：2020-12-17 00:00:00

abstract：:We aimed to evaluate the cardioprotective effect and mechanism of propofol in anthracycline-induced cardiomyocyte apoptosis. We selected the rat myocardial cell line, H9c2, and primary cardiomyocytes for in vitro study. The cardiomyocytes were treated with vehicle, Adriamycin® (ADM), propofol, or a combination of ADM ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao H,Zhang X,Zheng Y,Li Y,Wang X,Hu N,Zhou P,Wang K

更新日期：2018-04-18 00:00:00

abstract：Objective:The aim of this study was to establish a 3T3-L1 adipocyte model and ApoE-/- mouse model of intermittent hypoxia (IH) composite abnormal glucose metabolism (AGM) in vitro and in vivo and explore their synergistic damage effect leading to atherosclerosis (AS) and the influence of SREBP-1 signaling molecule-rela...

journal_title：Oxidative medicine and cellular longevity

authors： Ma L,Zhang J,Qiao Y,Sun X,Mao T,Lei S,Zheng Q,Liu Y

更新日期：2019-02-04 00:00:00

abstract：:Extracorporeal shock wave (ECSW) and adipose-derived mesenchymal stem cells (ADMSCs) have been recognized to have capacities of anti-inflammation and angiogenesis. We tested the hypothesis that ECSW and ADMSC therapy could attenuate ischemia-reperfusion- (IR-) induced thigh injury (femoral artery tightened for 6 h the...

journal_title：Oxidative medicine and cellular longevity

authors： Yin TC,Wu RW,Sheu JJ,Sung PH,Chen KH,Chiang JY,Hsueh SK,Chung WJ,Lin PY,Hsu SL,Chen CC,Chen CY,Shao PL,Yip HK

更新日期：2018-04-02 00:00:00

abstract：:Barley grass powder is the best functional food that provides nutrition and eliminates toxins from cells in human beings; however, its functional ingredients have played an important role as health benefit. In order to better cognize the preventive and therapeutic role of barley grass for chronic diseases, we carried ...

journal_title：Oxidative medicine and cellular longevity

authors： Zeng Y,Pu X,Yang J,Du J,Yang X,Li X,Li L,Zhou Y,Yang T

更新日期：2018-04-04 00:00:00

abstract：:The present study aims to explore the protective effect of human bone marrow mesenchymal stem cells (hBMSCs) on radiation-induced aortic injury (RIAI). hBMSCs were isolated and cultured from human bone marrow. Male C57/BL mice were irradiated with a dose of 18-Gy 6MV X-ray and randomly treated with either vehicle or h...

journal_title：Oxidative medicine and cellular longevity

authors： Shen Y,Jiang X,Meng L,Xia C,Zhang L,Xin Y

更新日期：2018-02-28 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase IV (CaMKIV) is an upstream regulator of CaMKK-CaMKIV signaling cascade that activates various transcription factors, thereby regulating several cellular activities including, neuronal communication and immune response. Owing to the abnormal expression in cancer and neurodege...

journal_title：Oxidative medicine and cellular longevity

authors： Gupta P,Khan S,Fakhar Z,Hussain A,Rehman MT,AlAjmi MF,Islam A,Ahmad F,Hassan MI

更新日期：2020-07-16 00:00:00

abstract：:Ischemia-reperfusion (IR) injury is directly related to the formation of reactive oxygen species (ROS), endothelial cell injury, increased vascular permeability, and the activation of neutrophils and platelets, cytokines, and the complement system. Several studies have confirmed the destructiveness of the toxic oxygen...

journal_title：Oxidative medicine and cellular longevity

authors： Ferrari RS,Andrade CF

更新日期：2015-01-01 00:00:00

abstract：:Previous studies have shown that metformin not only is a hypoglycemic agent but also has neuroprotective effects. However, the mechanism of action of metformin in ischemic stroke is unclear. Oxidative stress is an important factor in the pathogenesis of cerebral ischemia-reperfusion injury. It has been reported that m...

journal_title：Oxidative medicine and cellular longevity

authors： Zeng J,Zhu L,Liu J,Zhu T,Xie Z,Sun X,Zhang H

更新日期：2019-12-16 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and a great socioeconomic burden in the aging society. Compelling evidence demonstrates that molecular change characteristics for AD, such as oxidative stress and amyloid β (Aβ) oligomerization, precede by decades the onset of clinical dementia and that the...

journal_title：Oxidative medicine and cellular longevity

authors： Wojsiat J,Zoltowska KM,Laskowska-Kaszub K,Wojda U

更新日期：2018-01-31 00:00:00

abstract：:Patients with triple negative breast cancer (TNBC) often suffer relapse, and clinical improvements offered by radiotherapy and chemotherapy are modest. Although targeted therapy and immunotherapy have been a topic of significant research in recent years, scientific developments have not yet translated to significant i...

journal_title：Oxidative medicine and cellular longevity

authors： He Z,Zhang H,Li H,Wang Y,Qian J,Cai X,Sun L,Huang J

更新日期：2020-11-05 00:00:00

abstract：:Galectin-3 is an important modulator of several biological functions. It has been implicated in numerous disease conditions, particularly in the long-term complications of diabetes because of its ability to bind the advanced glycation/lipoxidation end products that accumulate in target organs and exert their toxic eff...

journal_title：Oxidative medicine and cellular longevity

authors： Menini S,Iacobini C,Blasetti Fantauzzi C,Pesce CM,Pugliese G

更新日期：2016-01-01 00:00:00

abstract：:As one of the major risks for urolithiasis, hyperoxaluria can be caused by genetic defect or dietary intake. And high oxalate induced renal epithelial cells injury is related to oxidative stress and mitochondrial dysfunction. Here, we investigated whether MitoTEMPO, a mitochondria-targeted antioxidant, could protect a...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang J,Wang Q,Xu C,Lu Y,Hu H,Qin B,Wang Y,He D,Li C,Yu X,Wang S,Liu J

更新日期：2017-01-01 00:00:00

abstract：:Based on the role of oxidative stress in the pathophysiological mechanisms of sepsis and the importance of PCT as a clinically applicable biomarker for early detection of inflammatory response initiation, we aimed this study at examining the correlation between PCT levels and oxidative stress parameters (prooxidants a...

journal_title：Oxidative medicine and cellular longevity

authors： Petrovic J,Turnic TN,Zivkovic V,Andjic M,Draginic N,Stojanovic A,Milinkovic I,Bolevich S,Jevdjic J,Jakovljevic V

更新日期：2020-09-04 00:00:00

abstract：:2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile, 5TIO1, is a new 2-aminothiophene derivative with promising pharmacological activities. The aim of this study was to evaluate its antioxidant activity in different areas of mice central nervous system. Male Swiss adult mice were in...

journal_title：Oxidative medicine and cellular longevity

authors： Fortes AC,Almeida AA,Oliveira GA,Santos PS,De Lucca Junior W,Mendonça Junior FJ,Freitas RM,Soares-Sobrinho JL,Soares MF

更新日期：2013-01-01 00:00:00

abstract：:The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a redox-sensitive transcription factor controlling a variety of downstream antioxidant and cytodefensive genes. Nrf2 has a powerful anti-inflammatory ...

journal_title：Oxidative medicine and cellular longevity

authors： Hassanein EHM,Sayed AM,Hussein OE,Mahmoud AM

更新日期：2020-04-22 00:00:00

abstract：:As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

journal_title：Oxidative medicine and cellular longevity

authors： Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

更新日期：2020-04-12 00:00:00

abstract：:Sphingosine kinase (SphK) exhibits two isoforms, SphK1 and SphK2. Both forms catalyze the synthesis of sphingosine 1-phosphate (S1P), a sphingolipid involved in ischemic preconditioning (IPC). Since the ratio of SphK1:SphK2 changes dramatically with aging, it is important to assess the role of SphK2 in IR injury and I...

journal_title：Oxidative medicine and cellular longevity

authors： Vessey DA,Li L,Jin ZQ,Kelley M,Honbo N,Zhang J,Karliner JS

更新日期：2011-01-01 00:00:00

abstract：:Oxidative stress and vascular endothelial dysfunction are established characteristics of cystic fibrosis (CF). Oxidative stress may contribute to vascular dysfunction via inhibition of nitric oxide (NO) bioavailability. Purpose. To determine if ingestion of a single antioxidant cocktail (AOC) improves vascular endothe...

journal_title：Oxidative medicine and cellular longevity

authors： Tucker MA,Fox BM,Seigler N,Rodriguez-Miguelez P,Looney J,Thomas J,McKie KT,Forseen C,Davison GW,Harris RA

更新日期：2019-06-19 00:00:00