Hybrid fluorescein-guided surgery for pituitary adenoma resection: a pilot study.

Abstract:

OBJECTIVE:The authors conducted a pilot study on hybrid fluorescein-guided surgery for pituitary adenoma resection and herein describe the feasibility and safety of this technique. METHODS:In this pilot study, the authors included all consecutive patients presenting with pituitary adenomas, functioning and nonfunctioning. They performed a hybrid fluorescein-guided surgical technique for tumor resection. An endonasal endoscopic approach was used; after exposure of the rostrum of the sphenoid sinus, they administered a bolus of 8 mg/kg of fluorescein sodium (FNa) intravenously, and during resection, they alternated between endoscopic and microscopic techniques to guide the resection under a YELLOW 560 filter. RESULTS:The study included 15 patients, 7 men (47%) and 8 women (53%). Of the pituitary adenomas, 7 (46%) were nonfunctioning, 6 (40%) were GH secreting, 1 (7%) was prolactin secreting, and 1 (7%) was ACTH secreting. There were no FNa-related complications (anaphylactic reactions); yellowish staining of urine, skin, and mucosa was seen in all patients and resolved in a maximum time of 24 hours. After color spectrophotometric analysis, the authors identified a statistical difference in fluorescence among tumor, gland, and scar tissue (p = 0.01). CONCLUSIONS:This is the first study of its kind to describe the feasibility and safety of using FNa to guide the resection of pituitary adenomas. The authors found this technique to be safe and feasible. It may be used to obtain better surgical results, especially for hormone-producing and recurring tumors, as well as for reducing the learning curve in pituitary adenoma surgery.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Romano-Feinholz S,Alcocer-Barradas V,Benítez-Gasca A,Martínez-de la Maza E,Valencia-Ramos C,Gómez-Amador JL

doi

10.3171/2019.1.JNS181512

subject

Has Abstract

pub_date

2019-04-05 00:00:00

pages

1490-1498

issue

5

eissn

0022-3085

issn

1933-0693

pii

2019.1.JNS181512

journal_volume

132

pub_type

杂志文章
  • Outcome following hindbrain decompression of symptomatic Chiari malformations in children previously treated with myelomeningocele closure and shunts.

    abstract::Between 1975 and 1989, 25 children treated with myelomeningocele closure and shunting for hydrocephalus at the Children's Hospital of Pittsburgh developed progressive lower brain-stem dysfunction from their Chiari malformation. Retrospective univariate and multivariate analyses of these cases were undertaken to assess...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.77.6.0881

    authors: Pollack IF,Pang D,Albright AL,Krieger D

    更新日期:1992-12-01 00:00:00

  • Comparison of percutaneous balloon compression and glycerol rhizotomy for the treatment of trigeminal neuralgia.

    abstract:OBJECT:The aim of this study was to compare percutaneous balloon compression (PBC) and percutaneous retrogasserian glycerol rhizotomy (PRGR) in terms of effectiveness, complications, and technical aspects. METHODS:Sixty-six consecutive PBC procedures were performed in 45 patients between January 2004 and December 2008...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2010.1.JNS091106

    authors: Kouzounias K,Lind G,Schechtmann G,Winter J,Linderoth B

    更新日期:2010-09-01 00:00:00

  • Fibroblastic tumor of the abducens nerve. Case report.

    abstract::Tumors of the cranial nerves are uncommon, and are usually schwannomas or neurofibromas. The authors describe a case of a fibroblastic tumor involving the sixth cranial nerve. Based upon electron microscopy and immunohistochemistry, the tumor was not of nerve-sheath origin, but was comprised of fibroblasts. Clinical, ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.2.0296

    authors: Nehls DG,Sonntag VK,Murphy AR,Johnson PC,Waggener JD

    更新日期:1985-02-01 00:00:00

  • Delineating gray and white matter involvement in brain lesions: three-dimensional alignment of functional magnetic resonance and diffusion-tensor imaging.

    abstract:OBJECT:The role of functional magnetic resonance (fMR) imaging has become increasingly important in the presurgical mapping of gray matter. Neurosurgical interventions often involve fiber bundles that connect critical functional areas. Recently, diffusion-tensor (DT) imaging has enabled the visualization of fiber bundl...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.6.1018

    authors: Hendler T,Pianka P,Sigal M,Kafri M,Ben-Bashat D,Constantini S,Graif M,Fried I,Assaf Y

    更新日期:2003-12-01 00:00:00

  • Acute nonlymphocytic leukemia following treatment of malignant glioma. Report of two cases.

    abstract::Two patients with malignant brain tumors who developed acute nonlymphocytic leukemia after treatment with radiation and chemotherapy are described. Both patients survived more than 2 years after diagnosis of the brain tumor. Survival following the diagnosis of leukemia was short, and both patients died of hemorrhage s...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.6.1287

    authors: Kempin S,Sundaresan N,Shapiro WB,Arlin Z

    更新日期:1984-06-01 00:00:00

  • The role of surgery for high-grade intracranial dural arteriovenous fistulas: importance of obliteration of venous outflow.

    abstract:OBJECT:Surgical intervention may be required if endovascular embolization is insufficient to completely obliterate intracranial dural arteriovenous fistulas (DAVFs). The authors report their 14-year experience with 23 patients harboring diverse intracranial DAVFs that required surgical intervention. METHODS:Between 19...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2008.9.JNS08733

    authors: Liu JK,Dogan A,Ellegala DB,Carlson J,Nesbit GM,Barnwell SL,Delashaw JB

    更新日期:2009-05-01 00:00:00

  • The effects of ischemia on long-tract neural conduction in the spinal cord.

    abstract::In this experiment, the effects of ischemia on neural conduction in the monkey spinal cord were studied. In six monkeys generalized ischemia of the spinal cord was created by bleeding the animals to a hypotensive level below the lower limits of autoregulation in the spinal cord. The progressive development of spinal c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.50.5.0639

    authors: Kobrine AI,Evans DE,Rizzoli HV

    更新日期:1979-05-01 00:00:00

  • Radiographic absence of the posterior communicating arteries and the prediction of cognitive dysfunction after carotid endarterectomy.

    abstract:OBJECT:Approximately 25% of patients exhibit cognitive dysfunction 24 hours after carotid endarterectomy (CEA). One of the purported mechanisms of early cognitive dysfunction (eCD) is hypoperfusion due to inadequate collateral circulation during cross-clamping of the carotid artery. The authors assessed whether poor co...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.5.JNS131736

    authors: Sussman ES,Kellner CP,Mergeche JL,Bruce SS,McDowell MM,Heyer EJ,Connolly ES

    更新日期:2014-09-01 00:00:00

  • Occurrence of meningioma 36 years after treatment for craniopharyngioma without radiation therapy. Case report.

    abstract::A meningioma occurred 36 years after surgical removal of a craniopharyngioma. No radiation therapy was instituted after the initial surgery. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1983.58.6.0947

    authors: Arienta C

    更新日期:1983-06-01 00:00:00

  • Presence of immunosuppressive factors in brain-tumor cyst fluid.

    abstract::The present investigation was conducted to examine the effects upon normal lymphocyte activation of the addition of brain-tumor cyst fluid or cerebrospinal fluid (CSF) to an in vitro culture system. It was believed that factors present in these fluids may play a role in local and systemic immunosuppression in brain-tu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1983.59.5.0790

    authors: Kikuchi K,Neuwelt EA

    更新日期:1983-11-01 00:00:00

  • Recurrent spinal cord tethering by sacral nerve root following lipomyelomeningocele surgery. Case report.

    abstract::A 21-year-old woman had recurrent progressive weakness/hypesthesia and pain in both lower extremities. At the age of 5 and 19 years, she had undergone surgical resection of a lipomyelomeningocele at L5-S1. Surgical exploration revealed that the cord was tethered and pulled over to the side by an excessively short righ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.75.1.0143

    authors: Barolat G,Schaefer D,Zeme S

    更新日期:1991-07-01 00:00:00

  • Giant-cell tumor of the sphenoid bone. Review of 10 cases.

    abstract::Giant-cell tumor rarely affects the sphenoid bone. Ten cases of this tumor seen at the Mayo Clinic are reviewed, bringing the number of cases in the world literature to 31. These tumors, which present in the second and third decades of life and are slightly more frequent in women than in men, may present with various ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1983.59.2.0322

    authors: Wolfe JT 3rd,Scheithauer BW,Dahlin DC

    更新日期:1983-08-01 00:00:00

  • Effect of phenytoin and corticosteroids on seizures and lipid peroxidation in experimental posttraumatic epilepsy.

    abstract::Head trauma, intracerebral hematoma formation, and hemorrhagic cerebral infarction cause extravasation of the intravascular contents, red blood cell (RBC) hemolysis, hemosiderin deposition within the neuropil, and an increased incidence of epilepsy. Reports conflict regarding the efficacy of the administration of prop...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.3.0467

    authors: Willmore LJ,Triggs WJ

    更新日期:1984-03-01 00:00:00

  • Spinal cord injury without radiological abnormality in preschool-aged children: correlation of magnetic resonance imaging findings with neurological outcomes.

    abstract:OBJECT:Spinal cord injury without radiological abnormality (SCIWORA) was defined in the era when magnetic resonance (MR) images were not popularly used as diagnostic tools. Although it is generally accepted that MR imaging can effectively illustrate the level and severity of spinal cord injury in the acute phase of tra...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2005.103.1.0017

    authors: Liao CC,Lui TN,Chen LR,Chuang CC,Huang YC

    更新日期:2005-07-01 00:00:00

  • Drowning hazard with deep brain stimulation: case report.

    abstract::The caudal zona incerta target within the posterior subthalamic area is an investigational site for deep brain stimulation (DBS) in Parkinson disease (PD) and tremor. The authors report on a patient with tremor-predominant PD who, despite excellent tremor control and an otherwise normal neurological examination, exhib...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.5.JNS15589

    authors: Bangash OK,Thorburn M,Garcia-Vega J,Walters S,Stell R,Starkstein SE,Lind CR

    更新日期:2016-05-01 00:00:00

  • Dural arteriovenous malformation of the skull base with intraosseous vascular nidus. Report of two cases.

    abstract::Intracranial arteriovenous malformations (AVM's) have been classified as pure pial, pure dural, and mixed pial and dural. Dural AVM's are relatively uncommon, with 377 cases documented up to 1990. These lesions were believed to be situated within the walls of the sinuses, but during the last decade researchers discove...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.4.0620

    authors: Malik GM,Mahmood A,Mehta BA

    更新日期:1994-10-01 00:00:00

  • Use of a wedged microcatheter for curative transarterial embolization of complex intracranial dural arteriovenous fistulas: indications, endovascular technique, and outcome in 21 patients.

    abstract:OBJECT:The aim of this study was to describe the application of a novel transarterial approach to curative embolization of complex intracranial dural arteriovenous fistulas (DAVFs). This technique is particularly useful in patients harboring high-grade DAVFs with direct cortical venous drainage or for whom transvenous ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.98.3.0498

    authors: Nelson PK,Russell SM,Woo HH,Alastra AJ,Vidovich DV

    更新日期:2003-03-01 00:00:00

  • Radiotherapy and CCNU in the treatment of high-grade supratentorial astrocytomas.

    abstract::Forty-one consecutive patients with supratentorial primary brain tumors (38 Grade III and IV astrocytomas, one giant-cell astrocytoma, and two cases with insufficient tissue for diagnosis) were randomly allocated within 2 weeks of surgery to one of three therapeutic groups. Group 1 (15 patients) received radiation the...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3171/jns.1976.45.2.0129

    authors: Weir B,Band P,Urtasun R,Blain G,Mclean D,Wilson F,Mielke B,Grace M

    更新日期:1976-08-01 00:00:00

  • Acute posttraumatic spinal cord herniation. Case report and review of the literature.

    abstract::Transdural herniations of the spinal cord are rare, and those occurring acutely after a spinal cord injury (SCI) are particularly unusual. In this report, the authors present the case of acute posttraumatic spinal cord herniation in a patient who sustained severe polytraumatic injuries. The clinical manifestations wer...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/spi.2001.94.2.0316

    authors: Marquardt G,Weidauer S,Zanella FE,Seifert V

    更新日期:2001-04-01 00:00:00

  • Delayed complication after Gamma Knife surgery for mesial temporal lobe epilepsy.

    abstract:OBJECT:Despite the controversy over the clinical significance of Gamma Knife surgery (GKS) for refractory mesial temporal lobe epilepsy (MTLE), the modality has attracted attention because it is less invasive than resection. The authors report long-term outcomes for 7 patients, focusing in particular on the long-term c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.2.JNS111296

    authors: Usami K,Kawai K,Koga T,Shin M,Kurita H,Suzuki I,Saito N

    更新日期:2012-06-01 00:00:00

  • Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note.

    abstract::Rapid growth and diffuse brain infiltration are hallmarks of malignant gliomas. The underlying molecular pathomechanisms of these tumors, however, remain to be determined. The authors present a novel glioma invasion model that allows researchers to monitor consecutively tumor cell proliferation and migration in an org...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.102.4.0738

    authors: Eyüpoglu IY,Hahnen E,Heckel A,Siebzehnrübl FA,Buslei R,Fahlbusch R,Blümcke I

    更新日期:2005-04-01 00:00:00

  • Improving health care transition and longitudinal care for adolescents and young adults with hydrocephalus: report from the Hydrocephalus Association Transition Summit.

    abstract::The health care needs of children with hydrocephalus continue beyond childhood and adolescence; however, pediatric hospitals and pediatric neurosurgeons are often unable to provide them care after they become adults. Each year in the US, an estimated 5000-6000 adolescents and young adults (collectively, youth) with hy...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.6.JNS188

    authors: Williams MA,van der Willigen T,White PH,Cartwright CC,Wood DL,Hamilton MG

    更新日期:2018-11-01 00:00:00

  • Early results of CyberKnife radiosurgery for arteriovenous malformations.

    abstract:OBJECT:The authors describe a method that utilizes an image-guided robotic radiosurgical apparatus (the CyberKnife) for treatment of cerebral arteriovenous malformations (AVMs). This procedure required the development of an original technique that allows a high degree of automation. METHODS:Angiographic images were im...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2008.10.JNS08749

    authors: Colombo F,Cavedon C,Casentini L,Francescon P,Causin F,Pinna V

    更新日期:2009-10-01 00:00:00

  • Phenotypic diversity in patients with craniosynostoses unrelated to Apert syndrome: the role of fibroblast growth factor receptor gene mutations.

    abstract:OBJECT:The goal of this study was to elucidate the genotype-phenotype relationship in syndromic craniosynostoses by analyzing the mutations of the fibroblast growth factor receptor (FGFR) gene and its clinical manifestations in patients, particularly those in atypical cases. METHODS:Twenty patients with craniosynostos...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2005.102.1.0023

    authors: Ito S,Sekido K,Kanno H,Sato H,Tanaka M,Yamaguchi K,Yamamoto I

    更新日期:2005-01-01 00:00:00

  • Alcohol and mortality after moderate to severe traumatic brain injury: a meta-analysis of observational studies.

    abstract::OBJECT Experimental studies have shown numerous neuroprotective properties of alcohol ("ethanol") after TBI, but clinical studies have provided conflicting results. The authors aimed to assess the relationship between positive blood alcohol concentration (BAC) on hospital admission and mortality after moderate to seve...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.3171/2015.4.JNS141746

    authors: Raj R,Mikkonen ED,Siironen J,Hernesniemi J,Lappalainen J,Skrifvars MB

    更新日期:2016-06-01 00:00:00

  • Early results of surgery in patients with nonfunctioning pituitary adenoma and analysis of the risk of tumor recurrence.

    abstract:OBJECT:Nonfunctioning pituitary adenomas (NFPAs) are benign tumors of the pituitary gland that typically cause visual and/or hormonal dysfunction. Surgery is the treatment of choice, but patients remain at risk for tumor recurrence for several years afterwards. The authors evaluate the early results of surgery and the ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/108/3/0525

    authors: Losa M,Mortini P,Barzaghi R,Ribotto P,Terreni MR,Marzoli SB,Pieralli S,Giovanelli M

    更新日期:2008-03-01 00:00:00

  • Distal posterior inferior cerebellar artery aneurysms: clinical features and management.

    abstract:OBJECT:Aneurysms located on the distal portion of the posterior inferior cerebellar artery (PICA) are uncommon, and their underlying pathology, natural history, and clinical management are poorly understood. To clarify these lesions more fully, the authors undertook a retrospective analysis of the clinical features and...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.97.4.0756

    authors: Lewis SB,Chang DJ,Peace DA,Lafrentz PJ,Day AL

    更新日期:2002-10-01 00:00:00

  • The nonsurgical nature of patients with subarachnoid or intraparenchymal hemorrhage associated with mild traumatic brain injury.

    abstract:OBJECT:Mild traumatic brain injury (mTBI), as defined by Glasgow Coma Scale (GCS) score of 13 or higher, is a common problem in the United States and worldwide, estimated to affect more than 1 million patients yearly. When associated with intracranial hemorrhage, it is a common reason for neurosurgical consultation and...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.10.JNS132713

    authors: Ditty BJ,Omar NB,Foreman PM,Patel DM,Pritchard PR,Okor MO

    更新日期:2015-09-01 00:00:00

  • Cerebral microvascular architecture following experimental cold injury.

    abstract::The sequential changes in microvascular architecture following local cold injury in rat brains were studied post mortem by scanning electron microscopy and the vascular casting method. The findings were compared with the results of immunohistochemical studies of injured endothelial cells using the bromodeoxyuridine (B...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.68.4.0608

    authors: Orita T,Nishizaki T,Kamiryo T,Harada K,Aoki H

    更新日期:1988-04-01 00:00:00

  • Patterns of care and outcomes among elderly individuals with primary malignant astrocytoma.

    abstract:OBJECT:This study was undertaken to evaluate the association between age at diagnosis, patterns of care, and outcome among elderly individuals with anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM). Methods Using the Surveillance, Epidemiology and End Results database, the authors identified 1753 individual...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/108/4/0642

    authors: Barnholtz-Sloan JS,Williams VL,Maldonado JL,Shahani D,Stockwell HG,Chamberlain M,Sloan AE

    更新日期:2008-04-01 00:00:00