Radiotherapy and CCNU in the treatment of high-grade supratentorial astrocytomas.

Abstract:

:Forty-one consecutive patients with supratentorial primary brain tumors (38 Grade III and IV astrocytomas, one giant-cell astrocytoma, and two cases with insufficient tissue for diagnosis) were randomly allocated within 2 weeks of surgery to one of three therapeutic groups. Group 1 (15 patients) received radiation therapy totaling 4000 to 4500 rads in 4 to 5 weeks. Group 2 (13 patients) received 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea CCNU) 130 mg/sq m orally every 6 weeks. Group 3 (13 patients) received radiation therapy plus CCNU as for Groups 1 and 2. When the disease progressed, patients in Groups 1 and 2 were crossed over to receive CCNU and irradiation respectively. The median survival time in these groups was 188, 259, and 252 days, and the mean survival 263, 262, and 329 days. The median time from diagnosis to crossover (Groups 1 and 2) or to progression (Group 3) was 163, 99, and 220 days, and the mean time was 172, 108, and 231 days. There was no statistically significant difference between the means or medians in any of these situations.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Weir B,Band P,Urtasun R,Blain G,Mclean D,Wilson F,Mielke B,Grace M

doi

10.3171/jns.1976.45.2.0129

subject

Has Abstract

pub_date

1976-08-01 00:00:00

pages

129-34

issue

2

eissn

0022-3085

issn

1933-0693

journal_volume

45

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::All patients who underwent decompressive lumbar laminectomy in the Washtenaw County, Michigan metropolitan area during a 7-year period were studied for the purpose of defining long-term outcome, clinical correlations, and the need for subsequent fusion. Outcome was determined by questionnaire and physical examination ...

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    doi:10.3171/jns.1994.81.5.0699

    authors: Tuite GF,Stern JD,Doran SE,Papadopoulos SM,McGillicuddy JE,Oyedijo DI,Grube SV,Lundquist C,Gilmer HS,Schork MA

    更新日期:1994-11-01 00:00:00

  • Seizure incidence in the acute postneurosurgical period diagnosed using continuous electroencephalography.

    abstract::OBJECTIVEDelay in diagnosis and subsequent treatment of nonconvulsive seizures can lead to worsened outcomes. The gold standard in detecting nonconvulsive seizures is continuous video-electroencephalography (cEEG). Compared to routine, 30-minute EEG, the use of cEEG increases the likelihood of capturing intermittent n...

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    pub_type: 杂志文章

    doi:10.3171/2018.1.JNS171466

    authors: Freund B,Probasco JC,Ritzl EK

    更新日期:2018-05-01 00:00:00

  • Transcriptional expression of survivin and its splice variants in brain tumors in humans.

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    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.4.0738

    authors: Yamada Y,Kuroiwa T,Nakagawa T,Kajimoto Y,Dohi T,Azuma H,Tsuji M,Kami K,Miyatake S

    更新日期:2003-10-01 00:00:00

  • Bleeding risk of cerebral cavernous malformations in patients on β-blocker medication: a cohort study.

    abstract::OBJECTIVECerebral cavernous malformations (CCMs) are frequently diagnosed vascular malformations of the brain. Although most CCMs are asymptomatic, some can be responsible for intracerebral hemorrhage or seizures. In selected cases, microsurgical resection is the preferred treatment option. Treatment with the unselect...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.12.JNS172404

    authors: Goldberg J,Jaeggi C,Schoeni D,Mordasini P,Raabe A,Bervini D

    更新日期:2018-06-15 00:00:00

  • Efficacy of intraarterial superselective indocyanine green videoangiography in cerebral arteriovenous malformation surgery in a hybrid operating room.

    abstract:OBJECTIVE:Although intravenous indocyanine green (ICG) videoangiography has been reported to be useful when applied to cerebral arteriovenous malformation (AVM) surgery, the ICG that remains after the procedure makes it difficult to understand the anatomy, to evaluate nidus blood flow changes, and to repeat ICG videoan...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2020.3.JNS20319

    authors: Shimada K,Yamaguchi T,Miyamoto T,Sogabe S,Korai M,Okazaki T,Kanematsu Y,Satomi J,Nagahiro S,Takagi Y

    更新日期:2020-05-22 00:00:00

  • Reduction of spinal cord injury by administration of iloprost, a stable prostacyclin analog.

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    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1997.86.6.1007

    authors: Taoka Y,Okajima K,Uchiba M,Murakami K,Harada N,Johno M,Naruo M,Okabe H,Takatsuki K

    更新日期:1997-06-01 00:00:00

  • The relationship between ruptured aneurysm location, subarachnoid hemorrhage clot thickness, and incidence of radiographic or symptomatic vasospasm in patients enrolled in a prospective randomized controlled trial.

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    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,随机对照试验

    doi:10.3171/2013.10.JNS13419

    authors: Abla AA,Wilson DA,Williamson RW,Nakaji P,McDougall CG,Zabramski JM,Albuquerque FC,Spetzler RF

    更新日期:2014-02-01 00:00:00

  • Computerized tomography findings in arteriovenous malformations of the brain.

    abstract::Computerized tomography (CT) scans of 54 patients with an arteriovenous malformation (AVM) of the brain were reviewed. The 31 males and 23 females (mean age: 33 years) were classified according to clinical presentation: 1) intracranial hemorrhage (30 patients); 2) seizure disorder (19 patients); and 3) other neurologi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.51.6.0765

    authors: LeBlanc R,Ethier R,Little JR

    更新日期:1979-12-01 00:00:00

  • Inverse correlation of epidermal growth factor receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines.

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    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.100.3.0523

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    更新日期:2004-03-01 00:00:00

  • Early versus delayed heparin reversal after carotid endarterectomy in the dog. A scanning electron microscopy study.

    abstract::The present study investigates the hematological reaction to arterial injury during the first 10 minutes after endarterectomy in dogs to determine if heparin reversal during this early period predisposes to thrombus formation. Known platelet physiology would predict that heparinization during this early period would b...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1983.58.5.0708

    authors: Ercius MS,Chandler WF,Ford JW,Burkel WE

    更新日期:1983-05-01 00:00:00

  • Unenhanced and gadolinium-DTPA-enhanced MR imaging in postoperative evaluation in pediatric brain tumors.

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    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1989.71.1.0049

    authors: Dickman CA,Rekate HL,Bird CR,Drayer BP,Medina M

    更新日期:1989-07-01 00:00:00

  • Combined supra/infratentorial-transsinus approach to large pineal region tumors.

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    pub_type: 杂志文章

    doi:10.3171/jns.1998.88.6.1050

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    更新日期:1998-06-01 00:00:00

  • Solitary dorsal intramedullary schwannoma. Case report.

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    pub_type: 杂志文章,评审

    doi:10.3171/jns.1991.74.5.0816

    authors: Herregodts P,Vloeberghs M,Schmedding E,Goossens A,Stadnik T,D'Haens J

    更新日期:1991-05-01 00:00:00

  • Pressure-volume index as a function of cerebral perfusion pressure. Part 2: The effects of low cerebral perfusion pressure and autoregulation.

    abstract::The pressure-volume index (PVI) was measured in six adult cats while cerebral perfusion pressure (CPP) was reduced from normal levels to below the autoregulatory range by a continuous infusion of adenosine triphosphate. Anesthesia was induced with methohexital and maintained with an N2O:O2 (70%:30%) mixture. Body temp...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.67.3.0377

    authors: Gray WJ,Rosner MJ

    更新日期:1987-09-01 00:00:00

  • Selective sacral rootlet neurectomy in the treatment of detrusor hyperreflexia. Technique and long-term results.

    abstract::Selective sacral neurectomy was performed in 12 patients with intractable urge incontinence of long duration (mean 12 years) caused by detrusor hyperreflexia. There was great variation in the innervation of the bladder, but resection of an S-3 root or rootlet was carried out in all patients. Six of the patients, who w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.68.2.0241

    authors: Tørring J,Petersen T,Klemar B,Søgaard I

    更新日期:1988-02-01 00:00:00

  • A more potent bystander cytocidal effect elicited by tumor cells expressing the herpes simplex virus-thymidine kinase gene than by fibroblast virus-producer cells in vitro.

    abstract::Retrovirus-mediated herpes simplex virus-thymidine kinase (HSV-tk) gene therapy is a promising approach in the treatment of brain tumors. Previous in vitro and in vivo studies have demonstrated a bystander effect in which nonmodified tumor cells in proximity to HSV-tk-modified tumor cells are killed with the modified ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.83.4.0698

    authors: Vrionis FD,Wu JK,Qi P,Cano W,Cherington V

    更新日期:1995-10-01 00:00:00

  • Atlantooccipital instability. Case report.

    abstract::A patient is presented who had neck pain and transient episodes of visual-field defect followed by unconsciousness when he hyperextended his neck. Radiographic examination revealed atlantooccipital instability on flexion and extension views. Treatment by fusion of the occiput to C-2 resulted in relief of symptoms. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.48.4.0636

    authors: Finney HL,Roberts TS

    更新日期:1978-04-01 00:00:00

  • Acidophil stem-cell pituitary adenoma in a prepubescent female. Case report.

    abstract::Acidophil stem-cell pituitary adenomas account for less than 5% of pituitary tumors. Only 15 cases have previously been reported, with a mean age of occurrence of 38.7 years. A case of this unusual tumor is reported in a prepubertal girl. Clinical symptoms included prominent behavioral disturbance with associated head...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1989.70.2.0266

    authors: Marks WA,Brumback RA,Schaefer GB,Pendleton BD,Farris BK,Culbertson JL

    更新日期:1989-02-01 00:00:00

  • Surgical strategy for distal anterior cerebral artery aneurysms: microsurgical anatomy.

    abstract:OBJECT:Most distal anterior cerebral artery (ACA) aneurysms arise at the pericallosal-callosomarginal artery (PerA-CMA) junction, which is usually located in the A3 segment of the ACA around the genu of the corpus callosum. Aneurysms in the PerA-CMA junction are divided into two types according to their location: supra...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.3.0517

    authors: Kawashima M,Matsushima T,Sasaki T

    更新日期:2003-09-01 00:00:00

  • Magnetic resonance imaging techniques for visualization of the subthalamic nucleus.

    abstract::The authors reviewed 70 publications on MR imaging-based targeting techniques for identifying the subthalamic nucleus (STN) for deep brain stimulation in patients with Parkinson disease. Of these 70 publications, 33 presented quantitatively validated results. There is still no consensus on which targeting technique ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/2011.6.JNS101571

    authors: Brunenberg EJ,Platel B,Hofman PA,Ter Haar Romeny BM,Visser-Vandewalle V

    更新日期:2011-11-01 00:00:00

  • Repair of a vertebral artery dissection. Case report.

    abstract::The case is presented of a 38-year-old woman who suffered multiple cerebellar infarctions as a result of emboli from a vertebral artery dissection. Surgical therapy led to a satisfactory recovery. This case emphasizes the importance of an aggressive approach to such lesions. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.4.0662

    authors: Alexander JJ,Glagov S,Zarins CK

    更新日期:1986-04-01 00:00:00

  • Hyperacute measurement of intracranial pressure, cerebral perfusion pressure, jugular venous oxygen saturation, and laser Doppler flowmetry, before and during removal of traumatic acute subdural hematoma.

    abstract:OBJECT:The poor prognosis for traumatic acute subdural hematoma (ASDH) might be due to underlying primary brain damage, ischemia, or both. Ischemia in ASDH is likely caused by increased intracranial pressure (ICP) leading to decreased cerebral perfusion pressure (CPP), but the degree to which these phenomena occur is u...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2001.95.4.0569

    authors: Verweij BH,Muizelaar JP,Vinas FC

    更新日期:2001-10-01 00:00:00

  • A historical case of beaten-copper cranium.

    abstract::The authors present the oldest historical case of a so-called beaten-copper cranium. The typical pattern was identified on a skull from a child, probably a boy, who died at approximately 6 years of age and was buried in a provisional cemetery used during the siege of Hanau, Germany, in 1635 and 1636. Morphological and...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.3171/ped.2007.106.1.71

    authors: Rühli FJ,Nicklisch N,Alt KW

    更新日期:2007-01-01 00:00:00

  • Premorbid oral antithrombotic therapy and risk for reaccumulation, reoperation, and mortality in acute subdural hematomas.

    abstract:OBJECT:Acute subdural hematomas (SDHs) impart serious morbidity and mortality on the elderly population, with only 5% of those older than 65 years of age attaining functional independence. Despite its widespread use, oral antithrombotic therapy (OAT) in the context of acute SDH has not been extensively studied. The aut...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2010.7.JNS10446

    authors: Panczykowski DM,Okonkwo DO

    更新日期:2011-01-01 00:00:00

  • Outpatient brain tumor craniotomy under general anesthesia.

    abstract::OBJECTIVE Outpatient craniotomy has many advantages to the psychological and physical well-being of patients, as well as benefits to the health care system. Its efficacy and safety have been well demonstrated, but barriers to its widespread adoption remain. Among the challenges is a perception that its application is ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.11.JNS152151

    authors: Au K,Bharadwaj S,Venkatraghavan L,Bernstein M

    更新日期:2016-11-01 00:00:00

  • Obstructive hydrocephalus caused by intraventricular collapse of malacotic brain. Case report.

    abstract::The authors present the case of a 68-year-old man who experienced acute obstructive hydrocephalus after having suffered an infarction in the occipital lobe. Histopathological and serial neuroimaging examinations revealed that portions of a large disintegrating occipital infarct had entered the lateral ventricle and ob...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2001.95.1.0119

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    更新日期:2001-07-01 00:00:00

  • Deep brain stimulation versus anterior capsulotomy for obsessive-compulsive disorder: a review of the literature.

    abstract::Obsessive-compulsive disorder (OCD) is a chronic and debilitating psychiatric condition. Traditionally, anterior capsulotomy (AC) was an established procedure for treatment of patients with refractory OCD. Over recent decades, deep brain stimulation (DBS) has gained popularity. In this paper the authors review the pub...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/2014.11.JNS132618

    authors: Pepper J,Hariz M,Zrinzo L

    更新日期:2015-05-01 00:00:00

  • Surgical management of atlantoaxial nonunions.

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    pub_type: 杂志文章

    doi:10.3171/jns.1995.83.2.0248

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  • Longitudinal evaluation of corticospinal tract in patients with resected brainstem cavernous malformations using high-definition fiber tractography and diffusion connectometry analysis: preliminary experience.

    abstract:OBJECT:Brainstem cavernous malformations (CMs) are challenging due to a higher symptomatic hemorrhage rate and potential morbidity associated with their resection. The authors aimed to preoperatively define the relationship of CMs to the perilesional corticospinal tracts (CSTs) by obtaining qualitative and quantitative...

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    pub_type: 杂志文章

    doi:10.3171/2014.12.JNS142169

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    更新日期:2015-11-01 00:00:00

  • Adult rhombencephalosynapsis. Case report.

    abstract::Rhombencephalosynapsis (RS) is a relatively rare developmental disorder of the cerebellum in which the cerebellar hemispheres are fused across the midline without being separated by a cleft or the vermis. The condition may be associated with hydrocephalus and other intracranial and extracranial abnormalities. The auth...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.93.2.0323

    authors: Guyot LL,Kazmierczak CD,Michael DB

    更新日期:2000-08-01 00:00:00