Acute nonlymphocytic leukemia following treatment of malignant glioma. Report of two cases.

Abstract:

:Two patients with malignant brain tumors who developed acute nonlymphocytic leukemia after treatment with radiation and chemotherapy are described. Both patients survived more than 2 years after diagnosis of the brain tumor. Survival following the diagnosis of leukemia was short, and both patients died of hemorrhage secondary to thrombocytopenia. A review of the literature reveals that leukemia after combined-modality treatment of malignant brain tumors is rare. A prolonged survival period from diagnosis of the primary tumor, treatment with nitrosoureas and radiation, plus the development of a preleukemic myelodysplastic syndrome are all important features of therapy-related nonlymphocytic leukemia.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Kempin S,Sundaresan N,Shapiro WB,Arlin Z

doi

10.3171/jns.1984.60.6.1287

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

1287-90

issue

6

eissn

0022-3085

issn

1933-0693

journal_volume

60

pub_type

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