Abstract:
:Peptidoglycan (PG) is an essential molecule for the survival of bacteria, and thus, its biosynthesis and remodeling have always been in the spotlight when it comes to the development of antibiotics. The peptidoglycan polymer provides a protective function in bacteria, but at the same time is continuously subjected to editing activities that in some cases lead to the release of peptidoglycan fragments (i.e., muropeptides) to the environment. Several soluble muropeptides have been reported to work as signaling molecules. In this review, we summarize the mechanisms involved in muropeptide release (PG breakdown and PG recycling) and describe the known PG-receptor proteins responsible for PG sensing. Furthermore, we overview the role of muropeptides as signaling molecules, focusing on the microbial responses and their functions in the host beyond their immunostimulatory activity.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Irazoki O,Hernandez SB,Cava Fdoi
10.3389/fmicb.2019.00500subject
Has Abstractpub_date
2019-03-28 00:00:00pages
500issn
1664-302Xjournal_volume
10pub_type
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