Abstract:
:Coinfection by bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) frequently has been observed in cattle that develop severe pneumonia. We recently reported that BRSV infection significantly increased PM adherence to bovine lower respiratory tract epithelial cells. However, the molecular mechanisms of enhanced PM adherence are not completely understood. To investigate whether BRSV infection regulates any cellular adherence receptors on bovine bronchus- and lung-epithelial cells, we performed proteomic and functional analyses. The proteomic analysis showed that BRSV infection increased the accumulation of the platelet-activating factor receptor (PAFR) in both cell types. Molecular experiments, including specific blockade, knockdown, and overexpression of PAFR, indicated that PM adherence to these cell types depended on PAFR expression. These findings highlight the role, in cattle with severe pneumonia, of the synergistic effect of coinfection by BRSV and PM in the lower respiratory tract.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Sudaryatma PE,Saito A,Mekata H,Kubo M,Fahkrajang W,Mazimpaka E,Okabayashi Tdoi
10.3389/fmicb.2020.01676subject
Has Abstractpub_date
2020-07-31 00:00:00pages
1676issn
1664-302Xjournal_volume
11pub_type
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