Abstract:
:Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound 18, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Quaglio D,Zhdanovskaya N,Tobajas G,Cuartas V,Balducci S,Christodoulou MS,Fabrizi G,Gargantilla M,Priego EM,Carmona Pestaña Á,Passarella D,Screpanti I,Botta B,Palermo R,Mori M,Ghirga F,Pérez-Pérez MJdoi
10.1021/acsmedchemlett.8b00608subject
Has Abstractpub_date
2019-02-26 00:00:00pages
639-643issue
4issn
1948-5875journal_volume
10pub_type
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