Abstract:
Objectives:To measure correlation and concordance between measured LDL cholesterol (mLDLc) and Friedewald's calculated LDL cholesterol (cLDLc). To compare the mLDLc and cLDLc values for various anthropometric measures and biochemical indices including insulin resistance, nephropathy, glycated hemoglobin and triglycerides. Methods:Two hundred thirty two subjects were included in this cross-sectional analysis from Jan-2016 to July-2017 from a target population visiting PNS HAFEEZ hospital. Mean age of the subjects was 46.56(±11.95) years (n=232). These subjects underwent clinical evaluation including measurement of anthropometric measurements, biochemical testing for fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), lipid profile, urine albumin creatinine ratio (UACR), and insulin. Correlation and concordance between mLDLc and Friedewald's cLDLc were measured. Finally, Comparison of risk evaluation for mLDLc and cLDLc between groups formulated based upon UACR (Based upon a cut off of 2.5 mg/g) and fasting triglycerides (Group-1 :< 1.0 mmol/L, Group-2: 1.0-1.99 mmol/L and Group-3 :> 1.99 mmol/) was carried out. Results:There was significant positive linear correlation between mLDLc and cLDLc [r=0.468, <0.001]. Kendall's Coefficient of concordance between mLDLc and cLDLc was 0.055 (p<0.001). Differences evaluated by one way ANOVA analysis for mLDLc between various triglycerides groups were only significant between group-1 and group-2 [{Group-1:Mean=2.40, (2.19-2.61), n=43}, {Group-2:Mean=2.81, (2.69-2.92), n=136}, [{Group-3:Mean=2.59,(2.37-2.81), n=53}],(p=0.004) in comparison to cLDLc [{Group-1:Mean=2.63, (2.43-2.84), n=43}, {Group-2:Mean=2.85, (2.76-2.93), n=136}, [{Group-3:Mean=2.75, (2.60-2.90), n=53}]. Calculated method for LDLc showed higher UACR than mLDLc. (p=0.021). Conclusion:cLDLc over estimates LDL-cholesterol in comparison to mLDLc. The correlation between cLDLc and mLDLc was only moderate. However, cLDLc provided better degree of risk prediction for nephropathy and glycated hemoglobin than mLDLc.
journal_name
Pak J Med Scijournal_title
Pakistan journal of medical sciencesauthors
Khan SH,Niazi NK,Sobia F,Fazal N,Manzoor SM,Nadeem Adoi
10.12669/pjms.35.2.679subject
Has Abstractpub_date
2019-03-01 00:00:00pages
388-393issue
2eissn
1682-024Xissn
1681-715Xpii
PJMS-35-388journal_volume
35pub_type
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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journal_title:Pakistan journal of medical sciences
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.343.14345
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journal_title:Pakistan journal of medical sciences
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.5.3073
更新日期:2020-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.3.1490
更新日期:2020-03-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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journal_title:Pakistan journal of medical sciences
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.6.1322
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journal_title:Pakistan journal of medical sciences
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.323.9496
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.3.1661
更新日期:2020-03-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.3.136
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.316.8204
更新日期:2015-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.5.1993
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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journal_title:Pakistan journal of medical sciences
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journal_title:Pakistan journal of medical sciences
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更新日期:2018-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.4.661
更新日期:2019-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
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journal_title:Pakistan journal of medical sciences
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更新日期:2013-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.321.8169
更新日期:2016-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.326.10995
更新日期:2016-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.323.9541
更新日期:2016-05-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.295.3830
更新日期:2013-09-01 00:00:00
abstract::Etiology of neonatal seizures (NNS) is diverse and hypocalcemia is one of the treatable causes. Neonatal hypocalcemia (NHC) due to congenital hypoparathyroidism, either permanent or transient, is extremely rare. Its biochemical abnormalities include hypocalcemia, hyperphosphatemia and low levels of intact parathyroid ...
journal_title:Pakistan journal of medical sciences
pub_type:
doi:10.12669/pjms.315.7807
更新日期:2015-09-01 00:00:00