Repurposed Antimicrobial Combination Therapy: Tobramycin-Ciprofloxacin Hybrid Augments Activity of the Anticancer Drug Mitomycin C Against Multidrug-Resistant Gram-Negative Bacteria.

abstract：:Volvariella volvacea is a typical edible Basidiomycete with a high-temperature tolerance. It has a strong fibrinolysis capability and consumes abundant agricultural wastes. In agricultural cultivation, mycelial subculturing has been adopted, leading to serious strain degeneration. In this study, continuous mycelial su...

journal_title：Frontiers in microbiology

authors： Chen X,Zhang Z,Liu X,Cui B,Miao W,Cheng W,Zhao F

更新日期：2019-09-03 00:00:00

abstract：:Capsaicin (CAP) reduces body weight mainly through activation of transient receptor potential vanilloid 1 (TRPV1) cation channel. However, recent evidence indicates that the gut microbiota influences many physiological processes in host and might provoke obesity. This study determined whether the anti-obesity effect o...

journal_title：Frontiers in microbiology

authors： Shen W,Shen M,Zhao X,Zhu H,Yang Y,Lu S,Tan Y,Li G,Li M,Wang J,Hu F,Le S

更新日期：2017-02-23 00:00:00

abstract：:Ocular toxoplasmosis (OT) is one of the most common causes of posterior uveitis. The signaling of triggering receptor expressed on myeloid cells (TREM)-1 amplifies inflammation, whereas TREM-2 signaling is anti-inflammatory. IL-1β is a major driver of inflammation during infection. Toll-like receptors (TLRs) play impo...

journal_title：Frontiers in microbiology

authors： Zhang Y,He J,Zheng H,Huang S,Lu F

更新日期：2019-10-09 00:00:00

abstract：:The term microbiome describes the genetic material encoding the various microbial populations that inhabit our body. Whilst colonization of various body niches (e.g., the gut) by dynamic communities of microorganisms is now universally accepted, the existence of microbial populations in other "classically sterile" loc...

journal_title：Frontiers in microbiology

authors： Whittle E,Leonard MO,Harrison R,Gant TW,Tonge DP

更新日期：2019-01-17 00:00:00

abstract：:Two human-infecting avian influenza viruses (AIVs), H7N9 and H10N8, have emerged in China, which further indicate that the H9N2 subtype of AIVs, as an internal gene donor, may have an important role in the generation of new viruses with cross-species transmissibility and pathogenicity. H9N2 viruses that contain such i...

journal_title：Frontiers in microbiology

authors： Ye G,Liang CH,Hua DG,Song LY,Xiang YG,Guang C,Lan CH,Ping HY

更新日期：2016-02-29 00:00:00

abstract：:The intestinal microbiome influences the health of animals. However, little is known about the impact of indoor conditions and sex on intestinal microbiome diversity and composition in ducks. The present study aimed to investigate differences in the cecal microbiome between male and female ducks reared on the floor (P...

journal_title：Frontiers in microbiology

authors： Zhu C,Xu W,Tao Z,Song W,Liu H,Zhang S,Li H

更新日期：2020-10-08 00:00:00

abstract：:This study examined fungal diversity and composition in conventional (CM) and desert farming (DE) systems in Oman. Fungal diversity in the rhizosphere of tomato was assessed using 454-pyrosequencing and culture-based techniques. Both techniques produced variable results in terms of fungal diversity, with 25% of the fu...

journal_title：Frontiers in microbiology

authors： Kazerooni EA,Maharachchikumbura SSN,Rethinasamy V,Al-Mahrouqi H,Al-Sadi AM

更新日期：2017-08-02 00:00:00

abstract：:Shigella spp., the etiological agent of shigellosis or "bacillary dysentery," are responsible for considerable morbidity and mortality in excess of a million deaths globally per year. Although PCR-based techniques (such as PCR-based dipstick biosensors) have been used for the molecular diagnosis of infectious disease,...

journal_title：Frontiers in microbiology

authors： Wang Y,Wang Y,Xu J,Ye C

更新日期：2016-11-18 00:00:00

abstract：:To avoid conflict between biofuel and food resource production, marine macroalgae (main algal polysaccharides) have been suggested as potent feedstock for biofuel production. Flammeovirga pacifica WPAGA1, a typical marine polysaccharide-degrading bacterium, can utilize crude agarose as the sole carbon source. Transcri...

journal_title：Frontiers in microbiology

authors： Gao B,Li L,Wu H,Zhu D,Jin M,Qu W,Zeng R

更新日期：2019-06-12 00:00:00

abstract：:Ionic liquids discovery has celebrated 100 years. They consist solely of ions, one of which is typically organic and asymmetrical. Remarkable physical and chemical properties stirred their use as alternative solvents in many chemical processes. The recent demonstration of their occurrence in nature might boost their i...

journal_title：Frontiers in microbiology

authors： Hartmann DO,Petkovic M,Silva Pereira C

更新日期：2016-02-08 00:00:00

abstract：:Francisella tularensis is the causative agent of a spectrum of diseases collectively known as tularemia. The extreme virulence of the pathogen in humans, combined with the low infectious dose and the ease of dissemination by aerosol have led to concerns about its abuse as a bioweapon. Until recently, nothing was known...

journal_title：Frontiers in microbiology

authors： Kilmury SL,Twine SM

更新日期：2011-01-07 00:00:00

abstract：:Initially thought as being non-immunogenic, recombinant AAVs have emerged as efficient vector candidates for treating monogenic diseases. It is now clear however that they induce potent immune responses against transgene products which can lead to destruction of transduced cells. Therefore, developing strategies to ci...

journal_title：Frontiers in microbiology

authors： Adriouch S,Franck E,Drouot L,Bonneau C,Jolinon N,Salvetti A,Boyer O

更新日期：2011-09-29 00:00:00

abstract：:Application of nitrogen (N) fertilizers, predominantly as urea, is a major source of reactive N in the environment, with wide ranging effects including increased greenhouse gas accumulation in the atmosphere and aquatic eutrophication. The soil microbial community is the principal driver of soil N cycling; thus, impro...

journal_title：Frontiers in microbiology

authors： Staley C,Breuillin-Sessoms F,Wang P,Kaiser T,Venterea RT,Sadowsky MJ

更新日期：2018-04-04 00:00:00

abstract：:In smallholder farms of Côte d'Ivoire, particularly in the northeast of the country, Cajanus cajan (pigeonpea) has become an important crop because of its multiple beneficial facets. Pigeonpea seeds provide food to make ends meet, are sold on local markets, and aerial parts serve as forage for animals. Since it fixes ...

journal_title：Frontiers in microbiology

authors： Fossou RK,Ziegler D,Zézé A,Barja F,Perret X

更新日期：2016-11-11 00:00:00

abstract：:Fusarium wilt is a devastating soil-borne fungal disease caused by Fusarium oxysporum f.sp. cubense (Foc). In recent years, some antifungal bacteria have been applied for the prevention and biocontrol of pathogenic fungi. In our study, a bacterial strain HQB-1, isolated from banana rhizosphere soil, was cultured for i...

journal_title：Frontiers in microbiology

authors： Xu Z,Wang M,Du J,Huang T,Liu J,Dong T,Chen Y

更新日期：2020-12-10 00:00:00

abstract：:The multidomain (B-NG) protein FlhF, a flagellar biogenesis regulator in several bacteria, is the third paralog of the signal recognition particle (SRP)-GTPases Ffh and FtsY, which are known to drive protein-delivery to the plasma membrane. Previously, we showed that FlhF is required for Bacillus cereus pathogenicity ...

journal_title：Frontiers in microbiology

authors： Mazzantini D,Fonnesu R,Celandroni F,Calvigioni M,Vecchione A,Mrusek D,Bange G,Ghelardi E

更新日期：2020-05-06 00:00:00

abstract：:The complexity of the pathogenesis of inflammatory bowel disease (ulcerative colitis and Crohn's disease) has led to the quest of empirically drug therapies, combining immunosuppressant agents, biological therapy and modulators of the microbiota. Helminth parasites have been proposed as an alternative treatment of the...

journal_title：Frontiers in microbiology

authors： Roig J,Saiz ML,Galiano A,Trelis M,Cantalapiedra F,Monteagudo C,Giner E,Giner RM,Recio MC,Bernal D,Sánchez-Madrid F,Marcilla A

更新日期：2018-05-23 00:00:00

abstract：:The compatible solute dimethylsulfoniopropionate (DMSP), made by many marine organisms, is one of Earth's most abundant organosulfur molecules. Many marine bacteria import DMSP and can degrade it as a source of carbon and/or sulfur via DMSP cleavage or DMSP demethylation pathways, which can generate the climate active...

journal_title：Frontiers in microbiology

authors： Liu J,Liu J,Zhang SH,Liang J,Lin H,Song D,Yang GP,Todd JD,Zhang XH

更新日期：2018-12-21 00:00:00

abstract：:Weaning is stressful for piglets involving nutritional, physiological, and psychological challenges, leading to an increase in the secretion of cortisol, changes in gut microbiome and metabolites, whereas the underlying relationships remain unclear. To elucidate this, 14 Meishan female piglets were divided into the we...

journal_title：Frontiers in microbiology

authors： Jiang X,Lu N,Zhao H,Yuan H,Xia D,Lei H

更新日期：2020-08-28 00:00:00

abstract：:Proteae, and especially Proteus mirabilis, are often the cause of urinary tract infections (UTIs) in humans. They were reported as carriers of extended-spectrum β-lactamase (ESBL) genes, and recently of carbapenemases, mostly carried by the Salmonella genomic island 1 (SGI1) and Proteus genomic island 1 (PGI1). Protea...

journal_title：Frontiers in microbiology

authors： Schultz E,Cloeckaert A,Doublet B,Madec JY,Haenni M

更新日期：2017-01-19 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to suppress T-cell responses. Recently, we demonstrated that the human-pathogenic fungi Candida albicans and Aspergillus fumigatus induced a distinct subset of neutrophilic MDSCs. To dissect Candida-mediated MDSC induction ...

journal_title：Frontiers in microbiology

authors： Singh A,Lelis F,Braig S,Schäfer I,Hartl D,Rieber N

更新日期：2016-10-13 00:00:00

abstract：:The human gastric lumen is one of the most hostile environments of the human body suspected to be sterile until the discovery of Helicobacter pylori (H.p.). State of the art next generation sequencing technologies multiply the knowledge on H.p. functional genomics as well as on the colonization of supposed sterile hum...

journal_title：Frontiers in microbiology

authors： Klymiuk I,Bilgilier C,Stadlmann A,Thannesberger J,Kastner MT,Högenauer C,Püspök A,Biowski-Frotz S,Schrutka-Kölbl C,Thallinger GG,Steininger C

更新日期：2017-12-14 00:00:00

abstract：:Mycotic infections and their effect on the human condition have been widely overlooked and poorly surveilled by many health organizations even though mortality rates have increased in recent years. The increased usage of immunosuppressive and myeloablative therapies for the treatment of malignant as well as non-malign...

journal_title：Frontiers in microbiology

authors： Espinosa V,Rivera A

更新日期：2016-03-03 00:00:00

abstract：:The marine picocyanobacterium Synechococcus sp. WH7803 possesses two glutamine synthetases (GSs; EC 6.3.1.2), GSI encoded by glnA and GSIII encoded by glnN. This is the first work addressing the physiological regulation of both enzymes in a marine cyanobacterial strain. The increase of GS activity upon nitrogen starva...

journal_title：Frontiers in microbiology

authors： Domínguez-Martín MA,Díez J,García-Fernández JM

更新日期：2016-06-28 00:00:00

abstract：:Historically, vaccines have been designed to mimic the immunity induced by natural exposure to the target pathogen, but this approach has not been effective for any parasitic pathogen of humans or complex pathogens that cause chronic disease in humans, such as Plasmodium. Despite intense efforts by many laboratories a...

journal_title：Frontiers in microbiology

authors： Proietti C,Doolan DL

更新日期：2015-01-22 00:00:00

abstract：:The environmental fate and potential impacts of nanopesticides on agroecosystems under realistic agricultural conditions are poorly understood. As a result, the benefits and risks of these novel formulations compared to the conventional products are currently unclear. Here, we examined the effects of repeated realisti...

journal_title：Frontiers in microbiology

authors： Simonin M,Colman BP,Tang W,Judy JD,Anderson SM,Bergemann CM,Rocca JD,Unrine JM,Cassar N,Bernhardt ES

更新日期：2018-07-31 00:00:00

abstract：:Microbial biofilms in gravity-driven membrane (GDM) filtration systems can efficiently degrade the cyanotoxin microcystin (MC), but it is unclear if this function depends on the presence of MC-producing cyanobacteria in the source water habitat. We assessed the removal of MC from added Microcystis aeruginosa biomass i...

journal_title：Frontiers in microbiology

authors： Silva MOD,Desmond P,Derlon N,Morgenroth E,Pernthaler J

更新日期：2019-04-18 00:00:00

abstract：:Genetic diversity of phylogenetic or functional markers is widely used as a proxy of microbial diversity. However, it remains unclear to what extent functional diversity (FD), gene sequence diversity and community functioning are linked. For a range of denitrifying bacteria, we analyzed the relationships between (i) t...

journal_title：Frontiers in microbiology

authors： Salles JF,Le Roux X,Poly F

更新日期：2012-06-12 00:00:00

abstract：:Prion-like proteins can switch between a soluble intrinsically disordered conformation and a highly ordered amyloid assembly. This conformational promiscuity is encoded in specific sequence regions, known as prion domains (PrDs). Prions are best known as the causative factors of neurological diseases in mammals. Howev...

journal_title：Frontiers in microbiology

authors： Pallarès I,Iglesias V,Ventura S

更新日期：2016-01-07 00:00:00

abstract：:Genome-resolved environmental metagenomic sequencing has uncovered substantial previously unrecognized microbial diversity relevant for understanding the ecology and evolution of the biosphere, providing a more nuanced view of the distribution and ecological significance of traits including phototrophy across diverse ...

journal_title：Frontiers in microbiology

authors： Ward LM,Cardona T,Holland-Moritz H

更新日期：2019-07-23 00:00:00