Abstract:
:Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to suppress T-cell responses. Recently, we demonstrated that the human-pathogenic fungi Candida albicans and Aspergillus fumigatus induced a distinct subset of neutrophilic MDSCs. To dissect Candida-mediated MDSC induction in more depth, we studied the relative efficacy of different pathogenic non-albicans Candida species to induce and functionally modulate neutrophilic MDSCs, including C. glabrata, C. parapsilosis, C. dubliniensis, and C. krusei. Our data demonstrate that the extent of MDSC generation is largely dependent on the Candida species with MDSCs induced by C. krusei and C. glabrata showing a higher suppressive activity compared to MDSCs induced by C. albicans. In summary, these studies show that fungal MDSC induction is differentially regulated at the species level and differentially affects effector T-cell responses.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Singh A,Lelis F,Braig S,Schäfer I,Hartl D,Rieber Ndoi
10.3389/fmicb.2016.01624subject
Has Abstractpub_date
2016-10-13 00:00:00pages
1624issn
1664-302Xjournal_volume
7pub_type
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