Differential Regulation of Myeloid-Derived Suppressor Cells by Candida Species.

Abstract:

:Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to suppress T-cell responses. Recently, we demonstrated that the human-pathogenic fungi Candida albicans and Aspergillus fumigatus induced a distinct subset of neutrophilic MDSCs. To dissect Candida-mediated MDSC induction in more depth, we studied the relative efficacy of different pathogenic non-albicans Candida species to induce and functionally modulate neutrophilic MDSCs, including C. glabrata, C. parapsilosis, C. dubliniensis, and C. krusei. Our data demonstrate that the extent of MDSC generation is largely dependent on the Candida species with MDSCs induced by C. krusei and C. glabrata showing a higher suppressive activity compared to MDSCs induced by C. albicans. In summary, these studies show that fungal MDSC induction is differentially regulated at the species level and differentially affects effector T-cell responses.

journal_name

Front Microbiol

authors

Singh A,Lelis F,Braig S,Schäfer I,Hartl D,Rieber N

doi

10.3389/fmicb.2016.01624

subject

Has Abstract

pub_date

2016-10-13 00:00:00

pages

1624

issn

1664-302X

journal_volume

7

pub_type

杂志文章
  • Effects of Peptide Thanatin on the Growth and Transcriptome of Penicillium digitatum.

    abstract::Penicillium digitatum is the most damaging pathogen provoking green mold in citrus fruit during storage, and there is an urgent need for novel antifungal agents with high efficiency. The aim of this study was to investigate the antifungal effects of peptide thanatin against P. digitatum and the molecular mechanisms. R...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.606482

    authors: Feng G,Li X,Wang W,Deng L,Zeng K

    更新日期:2020-12-14 00:00:00

  • The Addition of ViriditecTM Aqueous Ozone to Peracetic Acid as an Antimicrobial Spray Increases Air Quality While Maintaining Salmonella Typhimurium, Non-pathogenic Escherichia coli, and Campylobacter jejuni Reduction on Whole Carcasses.

    abstract::Currently, the most utilized antimicrobial in processing facilities is peracetic acid, PAA; however, this chemical is increasingly recognized as a hazard to human health. Preliminary evidence suggests that ozone, when introduced in a specific manner, can reduce the noxious nature of PAA. Therefore, the objective of th...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.03180

    authors: Dittoe DK,Feye KM,Peyton B,Worlie D,Draper MJ,Ricke SC

    更新日期:2019-01-08 00:00:00

  • A Novel MSCRAMM Subfamily in Coagulase Negative Staphylococcal Species.

    abstract::Coagulase negative staphylococci (CoNS) are important opportunistic pathogens. Staphylococcus epidermidis, a coagulase negative staphylococcus, is the third leading cause of nosocomial infections in the US. Surface proteins like Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) are major vi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00540

    authors: Arora S,Uhlemann AC,Lowy FD,Hook M

    更新日期:2016-04-29 00:00:00

  • Bacterial Community Composition and Potential Driving Factors in Different Reef Habitats of the Spermonde Archipelago, Indonesia.

    abstract::Coastal eutrophication is a key driver of shifts in bacterial communities on coral reefs. With fringing and patch reefs at varying distances from the coast the Spermonde Archipelago in southern Sulawesi, Indonesia offers ideal conditions to study the effects of coastal eutrophication along a spatially defined gradient...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00662

    authors: Kegler HF,Lukman M,Teichberg M,Plass-Johnson J,Hassenrück C,Wild C,Gärdes A

    更新日期:2017-04-20 00:00:00

  • Defining Nutrient Combinations for Optimal Growth and Polyhydroxybutyrate Production by Methylosinus trichosporium OB3b Using Response Surface Methodology.

    abstract::Methane and methanol are common industrial by-products that can be used as feedstocks for the production of value-added products by methylotrophic bacteria. Alphaproteobacterial methanotrophs are known to produce and accumulate the biopolymer polyhydroxybutyrate (PHB) under conditions of nutrient starvation. The prese...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01513

    authors: Zaldívar Carrillo JA,Stein LY,Sauvageau D

    更新日期:2018-07-18 00:00:00

  • Importance of Promyelocytic Leukema Protein (PML) for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication.

    abstract::Many DNA virus replication-related proteins are associated with promyelocytic leukemia protein (PML), a component of nuclear domain 10 (ND10), which has been investigated for its potential involvement in viral replication. In the case of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic gene products, K8 (K-bZIP), ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02324

    authors: Hossain MG,Ohsaki E,Honda T,Ueda K

    更新日期:2018-10-08 00:00:00

  • Genomic Characterization of Flavobacterium psychrophilum Serotypes and Development of a Multiplex PCR-Based Serotyping Scheme.

    abstract::Flavobacterium psychrophilum is a devastating bacterial pathogen of salmonids reared in freshwater worldwide. So far, serological diversity between isolates has been described but the underlying molecular factors remain unknown. By combining complete genome sequence analysis and the serotyping method proposed by Loren...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01752

    authors: Rochat T,Fujiwara-Nagata E,Calvez S,Dalsgaard I,Madsen L,Calteau A,Lunazzi A,Nicolas P,Wiklund T,Bernardet JF,Duchaud E

    更新日期:2017-09-12 00:00:00

  • Factors influencing the diversity of iron uptake systems in aquatic microorganisms.

    abstract::Iron (Fe) is an essential micronutrient for many processes in all living cells. Dissolved Fe (dFe) concentrations in the ocean are of the order of a few nM, and Fe is often a factor limiting primary production. Bioavailability of Fe in aquatic environments is believed to be primarily controlled through chelation by Fe...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2012.00362

    authors: Desai DK,Desai FD,Laroche J

    更新日期:2012-10-18 00:00:00

  • Expanding the Current Knowledge About the Role of Interleukin-10 to Major Concerning Bacteria.

    abstract::Interleukin-10 (IL-10) is one of the most important anti-inflammatory cytokine produced during bacterial infection. Two related phenomena explain the importance of IL-10 production in this context: first, the wide range of cells able to produce this cytokine and second, the wide effects that it causes on target cells....

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2018.02047

    authors: Peñaloza HF,Noguera LP,Riedel CA,Bueno SM

    更新日期:2018-09-18 00:00:00

  • PacBio and Illumina MiSeq Amplicon Sequencing Confirm Full Recovery of the Bacterial Community After Subacute Ruminal Acidosis Challenge in the RUSITEC System.

    abstract::The impact of subacute rumen acidosis (SARA) on the rumen bacterial community has been frequently studied in in vivo trials. Here we investigated whether these alterations can be mirrored by using the rumen simulation technique (RUSITEC) as an in vitro model for this disease. We hypothezised that the bacterial communi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.01813

    authors: Brede M,Orton T,Pinior B,Roch FF,Dzieciol M,Zwirzitz B,Wagner M,Breves G,Wetzels SU

    更新日期:2020-08-07 00:00:00

  • Green Tea Catechin-Inactivated Viral Vaccine Platform.

    abstract::Traditionally, chemical agents such as formalin (FA) and β-propiolactone (BPL) have long been used for the preparation of inactivated vaccines or toxoids. It has been shown that FA extensively modifies vaccine antigens and thus affects immunogenicity profiles, sometimes compromising the protective efficacy of the vacc...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02469

    authors: Lee YH,Jang YH,Byun YH,Cheong Y,Kim P,Lee YJ,Lee YJ,Sung JM,Son A,Lee HM,Lee J,Yang SW,Song JM,Seong BL

    更新日期:2017-12-12 00:00:00

  • Rapid Sequencing of Multiple RNA Viruses in Their Native Form.

    abstract::Long-read nanopore sequencing by a MinION device offers the unique possibility to directly sequence native RNA. We combined an enzymatic poly-A tailing reaction with the native RNA sequencing to (i) sequence complex population of single-stranded (ss)RNA viruses in parallel, (ii) detect genome, subgenomic mRNA/mRNA sim...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00260

    authors: Wongsurawat T,Jenjaroenpun P,Taylor MK,Lee J,Tolardo AL,Parvathareddy J,Kandel S,Wadley TD,Kaewnapan B,Athipanyasilp N,Skidmore A,Chung D,Chaimayo C,Whitt M,Kantakamalakul W,Sutthent R,Horthongkham N,Ussery DW,Jonsson

    更新日期:2019-02-25 00:00:00

  • Reveromycins A and B from Streptomyces sp. 3-10: Antifungal Activity against Plant Pathogenic Fungi In vitro and in a Strawberry Food Model System.

    abstract::This study was conducted to determine the antifungal activity of the metabolites from Streptomyces sp. 3-10, and to purify and identify the metabolites. Meanwhile, the taxonomic status of strain 3-10 was re-evaluated. The cultural filtrates of strain 3-10 in potato dextrose broth were extracted with ethyl acetate. The...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00550

    authors: Lyu A,Liu H,Che H,Yang L,Zhang J,Wu M,Chen W,Li G

    更新日期:2017-04-03 00:00:00

  • Combatting cyanobacteria with hydrogen peroxide: a laboratory study on the consequences for phytoplankton community and diversity.

    abstract::Experiments with different phytoplankton densities in lake samples showed that a high biomass increases the rate of hydrogen peroxide (HP) degradation and decreases the effectiveness of HP in the selective suppression of dominant cyanobacteria. However, selective application of HP requires usage of low doses only, acc...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00714

    authors: Weenink EF,Luimstra VM,Schuurmans JM,Van Herk MJ,Visser PM,Matthijs HC

    更新日期:2015-07-22 00:00:00

  • A Glacier Bacterium Produces High Yield of Cryoprotective Exopolysaccharide.

    abstract::Pseudomonas sp. BGI-2 is a psychrotrophic bacterium isolated from the ice sample collected from Batura glacier, Pakistan. This strain produces highly viscous colonies on agar media supplemented with glucose. In this study, we have optimized growth and production of exopolysaccharide (EPS) by the cold-adapted Pseudomon...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.03096

    authors: Ali P,Shah AA,Hasan F,Hertkorn N,Gonsior M,Sajjad W,Chen F

    更新日期:2020-02-11 00:00:00

  • SNORD126 Promotes Hepatitis C Virus Infection by Upregulating Claudin-1 via Activation of PI3K-AKT Signaling Pathway.

    abstract::Hepatitis C virus (HCV) infection involves a variety of viral and host factors, some of which promote the infection process. A small nucleolar RNA, C/D box 126 (SNORD126), was previously shown to be associated with hepatocellular carcinoma (HCC). However, the role of SNORD126 in HCV infection, which is one of the prim...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.565590

    authors: Qian X,Xu C,Wu B,Tang H,Zhao P,Qi Z

    更新日期:2020-09-15 00:00:00

  • Dynamic Alterations in Yak Rumen Bacteria Community and Metabolome Characteristics in Response to Feed Type.

    abstract::Current knowledge about the relationships between ruminal bacterial communities and metabolite profiles in the yak rumen is limited. This is due to differences in the nutritional and metabolic features between yak and other ordinary cattle combined with difficulties associated with farm-based research and a lack of te...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01116

    authors: Liu C,Wu H,Liu S,Chai S,Meng Q,Zhou Z

    更新日期:2019-05-22 00:00:00

  • The Profile and Antimicrobial Activity of Bacillus Lipopeptide Extracts of Five Potential Biocontrol Strains.

    abstract::In this study the efficacy of two different methods for extracting lipopeptides produced by five Bacillus strains-ethyl acetate extraction, and acid precipitation followed by methanol extraction-was investigated using mass spectrometry. High performance thin layer chromatography (HPTLC) was also used for the simultane...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00925

    authors: Dimkić I,Stanković S,Nišavić M,Petković M,Ristivojević P,Fira D,Berić T

    更新日期:2017-05-23 00:00:00

  • The Negative Effects of KPN00353 on Glycerol Kinase and Microaerobic 1,3-Propanediol Production in Klebsiella pneumoniae.

    abstract::1,3-Propanediol (1,3-PD) is a valuable chemical intermediate in the synthesis of polyesters, polyethers, and polyurethanes, which have applications in various products such as cloth, bottles, films, tarpaulins, canoes, foam seals, high-resilience foam seating, and surface coatings. Klebsiella pneumoniae can produce 1,...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02441

    authors: Jeng WY,Panjaitan NSD,Horng YT,Chung WT,Chien CC,Soo PC

    更新日期:2017-12-07 00:00:00

  • Sequence-based Analysis of the Vitis vinifera L. cv Cabernet Sauvignon Grape Must Mycobiome in Three South African Vineyards Employing Distinct Agronomic Systems.

    abstract::Recent microbiomic research of agricultural habitats has highlighted tremendous microbial biodiversity associated with such ecosystems. Data generated in vineyards have furthermore highlighted significant regional differences in vineyard biodiversity, hinting at the possibility that such differences might be responsib...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.01358

    authors: Setati ME,Jacobson D,Bauer FF

    更新日期:2015-11-30 00:00:00

  • Molecular Characteristics of Carbapenem-Resistant Enterobacter cloacae in Ningxia Province, China.

    abstract::The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has become a major public health concern worldwide and a new challenge in the treatment of infectious diseases. The molecular characteristics of Enterobacter cloacae in Ningxia China are unknown. In this study, we reported 10 carbapenem-resistant E. cloaca...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00094

    authors: Shi Z,Zhao H,Li G,Jia W

    更新日期:2017-01-31 00:00:00

  • Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce Long-Term Adaptation of E. coli Cultures in Large-Scale Bioreactors: Experimental Evidence and Mathematical Model.

    abstract::Rapidly changing concentrations of substrates frequently occur during large-scale microbial cultivations. These changing conditions, caused by large mixing times, result in a heterogeneous population distribution. Here, we present a powerful and efficient modeling approach to predict the influence of varying substrate...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01195

    authors: Nieß A,Löffler M,Simen JD,Takors R

    更新日期:2017-06-28 00:00:00

  • Early Ongoing Speciation of Ogataea uvarum Sp. Nov. Within the Grape Ecosystem Revealed by the Internal Variability Among the rDNA Operon Repeats.

    abstract::A yeast strain was isolated during a study on vineyard-associated yeast strains from Apulia in Southern Italy. ITS and LSU D1/D2 rDNA sequences showed this strain not to belong to any known species and was described as the type strain of Ogataea uvarum sp. nov., a close relative of O. philodendri. Several secondary pe...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01687

    authors: Roscini L,Tristezza M,Corte L,Colabella C,Perrotta C,Rampino P,Robert V,Vu D,Cardinali G,Grieco F

    更新日期:2018-08-03 00:00:00

  • The Association between Invasive Group A Streptococcal Diseases and Viral Respiratory Tract Infections.

    abstract::Viral infections of the upper respiratory tract are associated with a variety of invasive diseases caused by Streptococcus pyogenes, the group A streptococcus, including pneumonia, necrotizing fasciitis, toxic shock syndrome, and bacteremia. While these polymicrobial infections, or superinfections, are complex, progre...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2016.00342

    authors: Herrera AL,Huber VC,Chaussee MS

    更新日期:2016-03-21 00:00:00

  • The role of adjuvants in therapeutic protection against paracoccidioidomycosis after immunization with the P10 peptide.

    abstract::Paracoccidioidomycosis (PCM), a common chronic mycosis in Latin America, is a granulomatous systemic disease caused by the thermo-dimorphic fungus Paracoccidioides brasiliensis. The glycoprotein gp43 is the main antigen target of P. brasiliensis and a 15-mer internal peptide (QTLIAIHTLAIRYAN), known as P10, defines a ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2012.00154

    authors: Mayorga O,Muñoz JE,Lincopan N,Teixeira AF,Ferreira LC,Travassos LR,Taborda CP

    更新日期:2012-05-04 00:00:00

  • Geobacillus and Bacillus Spore Inactivation by Low Energy Electron Beam Technology: Resistance and Influencing Factors.

    abstract::Low energy electron beam (LEEB) treatment is an emerging non-thermal technology that performs surface decontamination with a minimal influence on food quality. Bacterial spore resistance toward LEEB treatment and its influencing factors were investigated in this study. Spores from Geobacillus and Bacillus species were...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02720

    authors: Zhang Y,Moeller R,Tran S,Dubovcova B,Akepsimaidis G,Meneses N,Drissner D,Mathys A

    更新日期:2018-11-23 00:00:00

  • Field Displacement of Aflatoxigenic Aspergillus flavus Strains Through Repeated Biological Control Applications.

    abstract::A popular pre-harvest strategy to mitigate aflatoxin contamination of corn involves field application of non-aflatoxigenic strains of Aspergillus flavus. The basis of this biological control may involve multiple factors, but competitive displacement of aflatoxigenic strains by the biocontrol strains is a likely mechan...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01788

    authors: Weaver MA,Abbas HK

    更新日期:2019-08-07 00:00:00

  • Herring Oil and Omega Fatty Acids Inhibit Staphylococcus aureus Biofilm Formation and Virulence.

    abstract::Staphylococcus aureus is notorious for its ability to become resistant to antibiotics and biofilms play a critical role in antibiotic tolerance. S. aureus is also capable of secreting several exotoxins associated with the pathogenesis of sepsis and pneumonia. Thus, the objectives of the study were to examine S. aureus...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01241

    authors: Kim YG,Lee JH,Raorane CJ,Oh ST,Park JG,Lee J

    更新日期:2018-06-15 00:00:00

  • Antimicrobial food packaging: potential and pitfalls.

    abstract::Nowadays food preservation, quality maintenance, and safety are major growing concerns of the food industry. It is evident that over time consumers' demand for natural and safe food products with stringent regulations to prevent food-borne infectious diseases. Antimicrobial packaging which is thought to be a subset of...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2015.00611

    authors: Malhotra B,Keshwani A,Kharkwal H

    更新日期:2015-06-16 00:00:00

  • Mammalian MicroRNAs: Post-Transcriptional Gene Regulation in RNA Virus Infection and Therapeutic Applications.

    abstract::RNA silencing mediated by microRNAs (miRNAs) is a recently discovered gene regulatory mechanism involved in various aspects of biology, such as development, cell differentiation and proliferation, and innate immunity against viral infections. miRNAs, which are a class of small (21-25 nucleotides) RNAs, target messenge...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2010.00108

    authors: Tsunetsugu-Yokota Y,Yamamoto T

    更新日期:2010-10-13 00:00:00