Abstract:
Objective:To evaluate the clinical efficacy of intensity modulated radiation therapy and endocrinotherapy for middle and advanced prostate cancer. Methods:Total 104 elderly patients with middle and advanced prostate cancer who were admitted to our hospital from November 2014 to August 2015 were selected using random number table method. They were divided into intensity-modulated radiotherapy combined with endocrinotherapy group (observation group) and conventional radiotherapy combined with endocrinotherapy group (control group), 52 each. The serum levels of prostate specific antigen (PSA) and free prostate antigen (f PSA) were measured three months after treatment. The short-term efficacy and toxic and side effects of the patients were observed, and the survival rate was recorded through three-year follow up. Results:The clinical effective rate of the observation group was 92.68%, and that of the control group was 70.73%; there was a significant difference between the two groups (P<0.05). The serum PSA and f PSA levels of the two groups were similar before treatment, but there was no significant difference (P>0.05). The serum PSA and f PSA levels after treatment were significantly lower than before treatment. The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). The one-year and three-year survival rates of the two groups were significantly different (90.0 vs. 80.0%, 60.0 vs. 43.3%, P>0.05). Conclusion:Intensity modulated radiotherapy combined with endocrinotherapy was safe and well tolerated in the treatment of middle and advanced prostate cancer. It can improve the short-term efficacy and effectively reduce the serum oncological index concentration of patients. It can be promoted in clinics.
journal_name
Pak J Med Scijournal_title
Pakistan journal of medical sciencesauthors
Zhang S,Zhao S,Fu Xdoi
10.12669/pjms.35.5.591subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1264-1269issue
5eissn
1682-024Xissn
1681-715Xpii
PJMS-35-1264journal_volume
35pub_type
杂志文章abstract:OBJECTIVE:To observe the fetomaternal morbidity and mortality with induction of labour in pregnant women with gestational hypertension. METHODS:The subjected study population included was 138 pregnant women with gestational hypertension. These pregnant women were between 34-40 weeks of gestational period in whom labou...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.331.10386
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Ventilator Associated Pneumonia (VAP) has an imperative place amongst nosocomial infections leading to increase morbidity and mortality rates. The present study aimed to determine risk factors for acquisition of ventilator- associated pneumonia in an intensive care unit (ICU). METHODS:A nested case-control s...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.295.3375
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abstract:Objective:A paradigm shift towards a PBL bidirectional dialogic feedback can enhance learners' performance. This study aimed to investigate undergraduate medical students' perceptions of their PBL feedback. Methods:We sent e-mail invitations to a web-based survey to year one and two students at College of Medicine, Ki...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.7.1778
更新日期:2020-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
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doi:10.12669/pjms.311.5858
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To determine the knowledge, misconceptions and motivations towards blood donation among university students in KSA. METHODS:This cross sectional study was carried out at the King Abdulaziz University, Rabigh campus, Jeddah, KSA. A total of 326 adult males were interviewed and each individual completed a ques...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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abstract:BACKGROUND AND OBJECTIVE:Each year millions of Muslims perform pilgrimage to Makkah, Saudi Arabia. It is particularly stressful during the peak five days, when all rituals have to be performed at specific periods of time at different sites. Poor diabetes control in people with diabetes predisposes to morbidity and incr...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.325.11217
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abstract:OBJECTIVE:To study the efficacy, desirable and undesirable effects of locally injectable preparation of botulinum toxin in patients suffering from Benign Essential Blepharospasm (BEB). METHODS:It was a prospective study carried out from October 2006 till November 2012 at a private set up, "Dr Shakaib's Eye Clinic", in...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.296.3853
更新日期:2013-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.2.243
更新日期:2019-03-01 00:00:00
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journal_title:Pakistan journal of medical sciences
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更新日期:2015-09-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.324.10381
更新日期:2016-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.314.7303
更新日期:2015-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
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doi:10.12669/pjms.302.4362
更新日期:2014-03-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.4.1651
更新日期:2020-05-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.345.15262
更新日期:2018-09-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.4.1920
更新日期:2020-05-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.321.8923
更新日期:2016-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.324.10409
更新日期:2016-07-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章
doi:10.12669/pjms.36.COVID19-S4.2785
更新日期:2020-05-01 00:00:00
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更新日期:2019-03-01 00:00:00
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journal_title:Pakistan journal of medical sciences
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更新日期:2018-07-01 00:00:00
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更新日期:2020-03-01 00:00:00
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更新日期:2020-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type:
doi:10.12669/pjms.314.7954
更新日期:2015-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
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更新日期:2015-09-01 00:00:00
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journal_title:Pakistan journal of medical sciences
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