Abstract：
:High-risk human papillomavirus (hrHPV) assessment as a primary screening test improves sensitivity but decreases specificity. Determining risk for cervical abnormalities and adapting policy accordingly may improve the balance between screening benefits and harms. Our aim is to assess the value of factors other than HPV in prediction of cervical abnormalities. Data from a Dutch prospective cohort were used. Women aged 18-29 years, not yet eligible for screening, were included in 2007. Data collection consisted of a questionnaire and a cervicovaginal self-sample. Linkage with PALGA (pathology database) was performed in 2017. The analyses included 1483 women. The full model, including sociodemographic and lifestyle factors, was compared to the null model, including baseline HPV only. The outcome of interest was cervical intraepithelial neoplasia 2 or worse (CIN2+). There were 86 women with CIN2+. Baseline hrHPV status was an important predictor (OR = 5.20, 95%CI = 3.27-8.27). The area under the ROC curve (AUC) of the null model was 0.67 (95%CI = 0.61-0.72). The full model had a slightly higher AUC of 0.73 (95%CI = 0.67-0.79). Bootstrap validation indicated that overfitting was present. This exploratory study has confirmed that a single hrHPV measurement is a strong predictor of cervical abnormalities, and additional risk factors in young women appeared to have limited added value. However, prediction based on hrHPV only does leave room for improvement. Future studies should therefore focus on women in the screening age range and search for other predictors to further enhance risk prediction. Adapting policy based on risk may eventually help optimise screening performance.
journal_name
Prev Medjournal_title
Preventive medicineauthors
van der Waal D,Bekkers RLM,Dick S,Lenselink CH,Massuger LFAG,Melchers WJG,Schmeink CE,Siebers AG,Broeders MJMdoi
10.1016/j.ypmed.2019.105927subject
Has Abstractpub_date
2020-01-01 00:00:00pages
105927eissn
0091-7435issn
1096-0260pii
S0091-7435(19)30410-4journal_volume
130pub_type
杂志文章abstract：OBJECTIVE:To identify determinants of use of smoking cessation aids among current and former smokers in the European Union (EU). METHODS:Data from n=9921 current and ex-smokers from 27 European countries (Eurobarometer 77.1, February-March 2012) were analysed. Multivariate binary logistic regression was used to assess...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2014.05.004
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:Cigarette smoking is the leading preventable cause of death and disease in the United States. Sexual minorities (lesbians, gay men, and bisexuals), smoke at higher rates than the general population. However, little else is known about sexual minority smokers. Furthermore, the sexual minority population is div...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2014.11.026
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Health professionals are credible sources of smoking cessation advice. This study describes changes in health professionals' reported provision of smoking cessation counseling activities for women during a community health education project that took place in two intervention counties (I) and compares these ...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.1999.0607
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:Pediatricians have an important and unique role to play in the anti-tobacco arena. They may prevent relapse to smoking in women who stopped smoking during pregnancy, encourage parents to protect infants and young children from environmental tobacco smoke (ETS), prevent the onset of smoking in children and ad...
journal_title：Preventive medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ypmed.2004.11.019
更新日期：2005-07-01 00:00:00
abstract：:All orthopedic treatment administered between 1970 and 1982 was analyzed in random subsamples of men 28, 38, and 48 years old being screened for serum gamma-glutamyltransferase (GGT) levels. Of 1,151 screened participants, 631 men had been treated for fracture, distortion, contusion, low-back pain with or without scia...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/0091-7435(86)90085-x
更新日期：1986-03-01 00:00:00
abstract：:Participation in secondary prevention programs such as cardiac rehabilitation (CR) reduces morbidity, mortality, and hospitalizations while improving quality of life. Executive function (EF) is a complex set of cognitive abilities that control and regulate behavior. EF predicts many health-related behaviors, but how E...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2019.105865
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:An elevated risk for coronary artery disease and lung cancer was reported for smokers and nonsmokers exposed to environmental tobacco smoke. Particularly in nonsmokers, in addition to the adverse effects of tobacco smoke, other factors which are associated with the exposure to environmental tobacco smoke may...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.2002.1024
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:In this cross-sectional study, we examined the relationship between socio-environmental characteristics of neighborhood of residence and the frequency of leisure-time physical activity (LTPA) among older adults from Porto (Portugal). METHOD:Data from EpiPorto - a prospective adult cohort study from Porto (Po...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2013.08.033
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To examine the effects of a tailored, print-based intervention for promoting physical activity among patients with type 2 diabetes. METHOD:This randomized controlled trial was conducted 2006-2007 in Tallahassee, FL. Patients diagnosed with type 2 diabetes (N=85; mean age=57.1 years; 74.1% Caucasian) were rec...
journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ypmed.2008.06.016
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:Few data are available to explain the ongoing increase in lung cancer mortality among Czech women. The study is aimed at examining the role of smoking and known or suspected cofactors. METHODS:Data collected by in-person interviews from 269 female lung cancer cases and 1079 controls were analyzed using unco...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.2001.1002
更新日期：2002-04-01 00:00:00
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journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2004.02.023
更新日期：2004-09-01 00:00:00
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journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.2000.0779
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:The objective of the study is to evaluate cross-sectional and longitudinal changes in children's commuting to school in a representative sample of a Brazilian city. METHODS:Two school-based studies were carried out in 2002 (n=2936; 7-10 years old) and 2007 (n=1232; 7-15 years old) in Florianopolis, Brazil. C...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2012.06.023
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:Cervical cancer causes over 4000 deaths yearly in the United States, although highly preventable through vaccination, screening, and early treatment. We aimed to determine demographic correlates for cervical cancer in North Carolina to identify target populations for interventions and to create a framework fo...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2012.01.020
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:We studied the contribution of physical load in daily activities, including activities in work, housekeeping, and leisure time, to the burden of low back problems (LBP) in the population. METHODS:Logistic regression models were used to calculate the association between physical load and several LBP paramete...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.2000.0737
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVE:This commentary offers a discussion of the paper by Bauman et al. (2011) published in Preventive Medicine. METHODS:We discuss the explanations for the findings of the manuscript by Bauman et al. (2011). RESULTS:We argue that there are social, commercial and environmental drivers of cycling rates and agree t...
journal_title：Preventive medicine
pub_type： 评论,杂志文章
doi：10.1016/j.ypmed.2011.12.011
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:The goal of this study is to better understand factors related to physician treatment of tobacco as a chronic medical condition. METHODS:In the fall of 2000, we conducted a mail survey of primary care physicians in a large mid-western health plan. The response rate was 61% (750/1235). The survey assessed ph...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2003.11.016
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Initiation of sun protection strategies can be promoted, to some extent, by educational efforts, but little is known about the merit of continuing education interventions in sustaining the desired behaviors or adding new behaviors. This prospective study clarifies the choices individuals make among the four ...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/0091-7435(92)90082-s
更新日期：1992-11-01 00:00:00
abstract：:Despite growing public awareness, health systems are struggling under the escalating burden of non-communicable diseases. While personal responsibility is crucial, alone it is insufficient. We argue that one must place themselves within the broader/global context to begin to truly understand the health implications of...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2014.05.006
更新日期：2014-07-01 00:00:00
abstract：INTRODUCTION:Data on hospitalization of immigrants to the United States are sparse, but small area analysis may improve the utility of existing data. METHODS:Applying logistic regression analysis to 2000 census and hospitalization data for New York City, we examined the odds of hospital admission by major diagnostic c...
journal_title：Preventive medicine
pub_type： 杂志文章
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更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:Attitudinal, mood, and personality variables have been identified as predictors of uptake of routine screening for a variety of cancers, including those of the breast, cervix, and colon. Little information exists, however, regarding characteristics of participants in ovarian cancer (OC) screening. METHOD:As...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2004.04.023
更新日期：2004-08-01 00:00:00
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journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
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更新日期：2017-06-01 00:00:00
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journal_title：Preventive medicine
pub_type： 杂志文章
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更新日期：1985-03-01 00:00:00
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journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/0091-7435(91)90011-r
更新日期：1991-01-01 00:00:00
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journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2012.07.011
更新日期：2012-10-01 00:00:00
abstract：:The 2014 National Research Council report on American incarceration optimistically anticipated the Affordable Care Act (ACA) would be "a turning point in the nation's health care, and … will provide unprecedented access to care for many people being released from correctional facilities." However, the ACA was not desi...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2019.105897
更新日期：2020-01-01 00:00:00
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journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ypmed.2014.12.019
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:The aim of this experiment was to examine the differential impact of a narrative and a non-narrative skin cancer message on health promoting actions and information-seeking behaviors. METHODS:Participants were 230 Flemish university students aged 18 to 25 years who participated in a web based experiment in F...
journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ypmed.2010.04.019
更新日期：2010-08-01 00:00:00
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journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2011.02.005
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Although colorectal cancer is not one of the major tobacco-related cancers, a possible association with tobacco has been suggested following the observation of a relationship between cigarette smoking and colorectal adenomas. The issue of a long latency of tobacco on colorectal carcinogenesis has also been s...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.1995.1091
更新日期：1995-11-01 00:00:00
