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Genetic diversity of Kemerovo virus and phylogenetic relationships within the Great Island virus genetic group.

Abstract：

:Kemerovo virus (KEMV) is a member of the Great Island virus genetic group, belonging to the tick-borne arboviruses of the genus Orbivirus within the family Reoviridae. Nine strains of KEMV, which were isolated from various locations in Russia, were sequenced by high-throughput sequencing to study their intraspecific diversity and the interspecific relationships of viruses within the Great Island genetic group. For the first time, multiple reassortment within KEMV was reliably demonstrated. Different types of independently emerged alternative reading frames in segment 9 and heterogeneity of the viral population in one of the KEMV strains were found. The hypothesis of the role of an alternative open reading frame (ORF) in segment 9 in KEMV cellular tropism was not confirmed in this study.

journal_name

Ticks Tick Borne Dis

journal_title

Ticks and tick-borne diseases

authors

Safonova MV,Gmyl AP,Lukashev AN,Speranskaya AS,Neverov AD,Fedonin GG,Pimkina EV,Matsvay AD,Khafizov KF,Karganova GG,Kozlovskaya LI,Valdokhina AV,Bulanenko VP,Dedkov VG

doi

10.1016/j.ttbdis.2019.101333

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

101333

issue

2

eissn

1877-959X

issn

1877-9603

pii

S1877-959X(19)30246-8

journal_volume

11

pub_type

杂志文章

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