当前位置： SCI文献检索 > BIOORGANIC CHEMISTRY期刊下所有文献 > Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae).

Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae).

Abstract：

:Two natural products, compounds 1 and 2 were isolated from the root bark of Ziziphus abyssinica for the first time and were structurally elucidated as β-amyrin and polpunonic acid, respectively. Both compounds were further subjected to an in vivo study in rats to evaluate their anti-arthritic potency. Compared to the arthritic control group, rats treated with different doses of 1 or 2 (3, 10, and 30 mg/kg) exhibited significantly higher total change in body weight as well as lower arthritic scores and total change in paw edema and erythema. Histopathological examinations of the hind paws of the rats further demonstrated the beneficial effects of both compounds as they significantly reversed cartilage erosion, subchondral cyst, and Weichselbaum's lacunae formation. Evidence of bone remodeling was also observed in all groups of rats treated with 1 or 2. Hematological and serum biochemical parameters were not significantly affected by treatment of 1 or 2. Taken together, the results from the present study suggest potential therapeutic benefit of β-amyrin and polpunonic acid in rheumatoid arthritis and related inflammatory disorders.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Henneh IT,Huang B,Musayev FN,Hashimi RA,Safo MK,Armah FA,Ameyaw EO,Adokoh CK,Ekor M,Zhang Y

doi

10.1016/j.bioorg.2020.103744

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

103744

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(20)30018-3

journal_volume

98

pub_type

杂志文章

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