Structurally modified glycyrrhetinic acid derivatives as anti-inflammatory agents.

Abstract:

:With the aim of finding new anti-inflammatory drugs, a series of new Glycyrrhetinic acid derivatives (1-34) have been designed and synthesized by structural modification, and their anti-inflammatory activities in vitro have been evaluated. The anti-inflammatory activities assay demonstrated that compound 5b suppressed the expression of pro-inflammatory cytokines including IL-6, TNF-α and NO, it also suppressed the expression of iNOS and COX-2 in LPS-induced RAW264.7 cells in a dose-dependent manner. Additionally, western blot results indicated that the suppressing effect of compound 5b on pro-inflammatory cytokines were correlated with the suppression of NF-κB and MAPK signaling pathways. The results attained in this study indicated that compound 5b had the potential to be developed into an anti-inflammation agent and it may be applied to the prevention and treatment of inflammatory diseases.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Bian M,Zhen D,Shen QK,Du HH,Ma QQ,Quan ZS

doi

10.1016/j.bioorg.2020.104598

subject

Has Abstract

pub_date

2020-12-29 00:00:00

pages

104598

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(20)31896-4

journal_volume

107

pub_type

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