Abstract:
PURPOSE:The cholinergic anti-inflammatory pathway may play an important role in early burn edema. Therefore, we evaluated the influence of cdp-choline on early systemic burn edema and leukocyte activation in shock in rat mesenteries after burn plasma transfer. METHODS:Burn plasma harvested from donor rats 4 hours after thermal injury (30% total body surface area, 100°C water, 12 seconds) was administered intravenously to healthy animals during 2 hours of intravital microscopy. Shamburn plasma (same procedure but water at 37°C) was transferred for negative controls. In the study group, bolus injection of 100 mg/kg body weight cdp-choline was undertaken 15 minutes before examination. Intravital microscopy was performed in the ileal portion of rat mesenteries at 0, 60, and 120 minutes. Capillary leakage was assessed by fluorescein isothiocyanate-albumin extravasation and leukocyte-endothelial interaction were observed via transillumination microscopy. To assure comparable hemodynamic conditions, microhemodynamic parameters, foremost venular wall shear rate, were assessed. RESULTS:Capillary leakage increased significantly after burn plasma transfer when compared to the shamburn group. Additional intravenous administration of cdp-choline attenuates macromolecular efflux to shamburn levels. Leukocyte activation is reduced after cdp-choline treatment. CONCLUSIONS:The significant increase of albumin efflux in rat mesenteries after burn plasma transfer is decreased by additional cdp-choline bolus administration. Further investigations for proof of the relevance of the cholinergic anti-inflammatory pathway in early burn trauma are strongly required.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Hernekamp JF,Hu SX,Schmidt VJ,Vogelpohl J,Kneser U,Kremer Tdoi
10.1097/SAP.0000000000000605subject
Has Abstractpub_date
2015-10-01 00:00:00pages
388-92issue
4eissn
0148-7043issn
1536-3708pii
00000637-201510000-00007journal_volume
75pub_type
杂志文章abstract::Local fascial flaps independently are a versatile option, reliable when properly designed, and technically simple to execute especially when compared to microsurgical tissue transfers. Although free flaps continue to be the method of choice to repair major distal extremity defects, for smaller wounds it could be prefe...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199704000-00014
更新日期:1997-04-01 00:00:00
abstract::We propose that, the face should be regarded as an organ. We compare the anatomic structure and functions of the face with those of the kidney, one of the most commonly transplanted solid organs. Composite tissue allografts demonstrated to improve the quality of life. Although not classified as a life-essential transp...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181844ea3
更新日期:2008-09-01 00:00:00
abstract::Out of 262 hands with total finger amputations treated by replantation of finger/fingers from January 2001 until January 2006, there were only 6 cases of type III ring avulsion injuries, all of which were replanted. Radical resection of the damaged part of the artery with primary vein grafting was used in each case; o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000252717.88972.01
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Preoperative localization of the perforators allows precise planning of the flap design and improves surgical efficiency. Recently, infrared thermography is introduced as a reliable alternative, where the perforator corresponds to the "hot spot" on the thermogram. This study aims to compare the application o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002369
更新日期:2020-05-01 00:00:00
abstract::Local infection is a rare complication after aesthetic rhinoplasty. In the past serious complications and 1 death have been reported. We present 5 cases of local infection after primary and secondary procedures. Infection seems to have more to do with technical details during an operation, such as the external lateral...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198610000-00007
更新日期:1986-10-01 00:00:00
abstract::Abdominal wall reconstruction of ventral hernia defects with loss of visceral domain and inadequate soft-tissue coverage presents a surgical challenge. Four patients with large, skin grafted ventral hernia defects were treated by staged abdominal wall reconstruction. During the initial stage, tissue expanders were pla...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200044020-00004
更新日期:2000-02-01 00:00:00
abstract::The gold standard for mandibular defect reconstruction is the fibular free flap. Nevertheless, the pedicled osteomuscular dorsal scapular flap as a reconstructive tool offers promise for mandibular defect reconstruction and could be the first choice in certain circumstances. Its use in resource-limited settings offers...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318230992e
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to investigate the efficacy of cilostazol for prevention of thrombosis in microsurgical anastomosis. We used not only a patency test, but also ultrasonography to evaluate the blood flow volume (FV) more accurately and objectivity. In addition, we evaluated the accuracy and sensitivity of ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31819aad6c
更新日期:2010-04-01 00:00:00
abstract::Postoperative hematoma is a complication of septal surgery that can be associated with significant morbidity and possibly even mortality in some cases. A simple suction drainage technique using a scalp vein cannula and vacuum tube can prevent a septal hematoma without the need for bulky nasal packing (with its attenda...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199002000-00017
更新日期:1990-02-01 00:00:00
abstract::Previous work in our laboratory has indicated that ischemic preconditioning improves musculocutaneous flap survival 2.5 times that of the control flap area when the flaps are subsequently subjected to 4 hours of global ischemia. The preconditioning protocol used in this study was arbitrarily designed to be 10 minutes ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199804000-00018
更新日期:1998-04-01 00:00:00
abstract::Regional metastases from head and neck cutaneous tumors are uncommon, and most present within 2 years from initial diagnosis. Occasionally such metastases may manifest at a later date, increasing the possibility of being derived from a second noncutaneous primary cancer of the head and neck region. The authors studied...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199903000-00010
更新日期:1999-03-01 00:00:00
abstract::A case of a closed rupture of a single slip of flexor digitorum superficialis to the little finger is described. Closed rupture injuries of the flexor digitorum profundus tendon are quite common, but closed injuries to the superficialis tendon have been rarely reported. A single slip avulsion rupture of this tendon wo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200110000-00012
更新日期:2001-10-01 00:00:00
abstract::Lymphedema is a condition characterized by progressive swelling and adipose deposition that occurs commonly after lymphadenectomy. Recent clinical studies have suggested that the transfer of lymph nodes to the lymphedematous limb can improve lymphatic function. In this report, we investigate dynamic modulation of lymp...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000428
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:We describe the risk factors for complications and outcome of perineal wounds after abdominoperineal resections (APRs). METHODS:A retrospective chart review was performed, and patient demographics, risk factors, extent of APR, closure of perineal wounds, exposure to radiation, and outcome were collected. R...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31823fac2b
更新日期:2013-08-01 00:00:00
abstract::From 1979 to 1983, 14 patients were treated at the University of Maryland Hospital for injuries sustained as a result of the injection of crushed pentazocine tablets partially dissolved in water into the arterial system of the upper extremity. Eight patients received intraarterial reserpine within 15 hours of the inju...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198701000-00010
更新日期:1987-01-01 00:00:00
abstract::Primary or delayed primary repair of flexor tendon lacerations in the digital sheath has become the accepted practice among surgeons expert in the treatment of hand injuries. The youngest patient reported in the literature we reviewed was 3 months old. We report a case of flexor tendon laceration at the time of delive...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198211000-00011
更新日期:1982-11-01 00:00:00
abstract::We investigated three sheathing materials (autogenous vein, silastic, and polyglycolic acid fine mesh) using the rat model. Forty rats were divided into five groups of eight animals each. Group A animals underwent transection of the sciatic nerve but had no repair. In Group B, a standard epineural repair was performed...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199509000-00008
更新日期:1995-09-01 00:00:00
abstract::In this study we present the first experimental vascularized penile allogenic transplantation model in the rat. In group 1 (n = 6), the vascular anatomy of the male rat perineal region was determined. In 12 Lewis rats of group 2 (n = 24), the penile composite graft was transplanted as isotransplant by microvascular an...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31817dc4d8
更新日期:2009-03-01 00:00:00
abstract::This article describes a model of chronic nerve compression in the rat. The sciatic nerve of adult male Sprague Dawley rats was banded with a 1-cm Silastic tube for varying periods of time. Morphometric analysis, electrodiagnostic studies, and histological evaluation were carried out 3, 5, 8, and 12 months after bandi...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198711000-00008
更新日期:1987-11-01 00:00:00
abstract::Four cases of unilateral temporomandibular (TM) joint ankylosis were successfully treated by metatarsophalangeal to TM joint replacement by microvascular technique. Results 6 to 20 months postoperatively were encouraging. Further follow-up studies are necessary to evaluate the long-term results. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198512000-00008
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Implant-based breast reconstruction is commonly performed by plastic surgeons worldwide. Bacterial contamination is of paramount concern because of its role in biofilm formation and capsular contracture. Plastic surgeons have adopted a variety of perioperative interventions in efforts to reduce implant conta...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000822
更新日期:2017-02-01 00:00:00
abstract::Craniofacial surgical techniques have yielded better methods of treating severe craniofacial trauma. In this paper surgical techniques are discussed in principle and specifically presented through case reports. We conclude that the most important factors for successful reconstruction after craniofacial trauma are to d...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198612000-00012
更新日期:1986-12-01 00:00:00
abstract::Forelimb buds of rat embryos at day 13 of gestation were cut and cultured in Dulbecco's modified Eagle medium. In the absence of serum, the epidermis did not cover the wound surface. In the presence of fetal calf serum or ultroser G, a serum substitute, epidermal wound closure appeared in a concentration-dependent man...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198912000-00002
更新日期:1989-12-01 00:00:00
abstract::A 4-year-old girl was referred to the plastic surgery unit with metastatic malignant melanoma diagnosed in a cervical lymph node. She had previously undergone excision of a Spitz nevus of the cheek at age 18 months. The management of this patient is discussed along with a review of the literature relating to Spitz nev...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000037277.03962.4F
更新日期:2003-05-01 00:00:00
abstract::The reconstruction of scalp defects presents a clinical challenge. Free tissue transfer has played an increasingly important role in the reconstruction of complex scalp defects. In many cases, patient medical comorbidities along with the length of the operative procedures incurs significant patient risk. Artificial de...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318180c913
更新日期:2009-06-01 00:00:00
abstract::The Lymphatic Microsurgical Preventing Healing Approach (LYMPHA) procedure entails performing a lymphovenous bypass (LVB) at the time of axillary lymph node dissection to reduce lymphedema risk. The two most common fluorophores utilized in LVB are blue dye and indocyanine green. We developed a novel application of flu...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001034
更新日期:2017-06-01 00:00:00
abstract::An unusual case of extensive cutaneous leishmaniasis of the upper limb in a patient with leukemia is presented. A trial of medical therapy (sodium stibogluconate) resulted in rapid healing of the large ulcers. The incidence of leishmaniasis is increasing globally as a result of the ease of travel and migrating populat...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200206000-00018
更新日期:2002-06-01 00:00:00
abstract::Although the etiology of nonsyndromic forms of craniosynostosis remains uncertain, recent experiments from our laboratory have demonstrated that fetal head constraint induces cranial suture fusion in mice through a process associated with altered patterns of transforming growth factor beta (TGF-beta) isoform expressio...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200105000-00015
更新日期:2001-05-01 00:00:00
abstract::This article discusses a method of reconstruction of breast crease for correction of postoperative deformities. These deformities are usually the result of implant insertion for the purpose of breast enlargement or reconstruction. The operation is performed by creating a new crease in the appropriate site by suturing ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200103000-00013
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:This study aimed to present the results of a series of forequarter amputations (FQAs) and to evaluate the reconstructive methods used. SUMMARY BACKGROUND DATA:Although FQA has become a rare procedure in the era of limb-sparing treatment of extremity malignancies, it is a useful option when resection of a sho...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002204
更新日期:2020-06-01 00:00:00