Penis allotransplantation model in the rat.

Abstract:

:In this study we present the first experimental vascularized penile allogenic transplantation model in the rat. In group 1 (n = 6), the vascular anatomy of the male rat perineal region was determined. In 12 Lewis rats of group 2 (n = 24), the penile composite graft was transplanted as isotransplant by microvascular anastomosis of the pedicle of the penis to the saphenous vessels and in another 12 Lewis rats of group 2, penile composite graft was transplanted without vascular anastomosis. In group 3 (n = 12), penis composite graft was transplanted from 6 Lewis-Brown-Norway donors to 6 Lewis recipients under CsA immunosuppression. Direct observation, somatosensory evoked potential test, histologic examination and microangiography were used to assess the viability of the transplants. All vascularized isotransplants and allotransplants survived over 200 days (still under observation) whereas all the nonvascularized grafts were necrosed at 7 days posttransplant. In this study the new penile allograft transplantation model in the rat was developed and a new method of blood supply to a vascularized composite tissue with directly artery-to-corpus spongiosum anastomosis was introduced.

journal_name

Ann Plast Surg

authors

Sonmez E,Nasir S,Siemionow M

doi

10.1097/SAP.0b013e31817dc4d8

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

304-10

issue

3

eissn

0148-7043

issn

1536-3708

pii

00000637-200903000-00020

journal_volume

62

pub_type

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