A comparative analysis of the ability of five classes of pharmacological agents to augment skin flap survival in various models and species: an attempt to standardize skin flap research.

Abstract:

:There is a myriad of research in the pharmacological manipulation of skin flap survival. However, skepticism exists as to whether any of these drugs is clinically useful. We evaluated the efficacy of five categories of agents in improving skin flap survival in five different rat flap models. Diltiazem, isoxsuprine hydrochloride, nitroglycerin, prazosin hydrochloride (two doses), and methyldopa were compared in a double-blind, randomized fashion. Their benefits were assessed in a musculocutaneous flap, axial flap, and three types of random flaps. The "best" drug was determined to be nitroglycerin. Its efficacy was verified in a primate model.

journal_name

Ann Plast Surg

authors

Waters LM,Pearl RM,Macaulay RM

doi

10.1097/00000637-198908000-00004

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

117-22

issue

2

eissn

0148-7043

issn

1536-3708

journal_volume

23

pub_type

杂志文章
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