Toward an understanding of nonsyndromic craniosynostosis: altered patterns of TGF-beta receptor and FGF receptor expression induced by intrauterine head constraint.

Abstract:

:Although the etiology of nonsyndromic forms of craniosynostosis remains uncertain, recent experiments from our laboratory have demonstrated that fetal head constraint induces cranial suture fusion in mice through a process associated with altered patterns of transforming growth factor beta (TGF-beta) isoform expression. Other recent studies have highlighted the role of secreted signaling molecules, including members of the TGF-beta superfamily and the fibroblast growth factors (FGFs), as well as their receptors, in regulating suture development and fusion. The purpose of these experiments was to examine the potential role of TGF-beta receptors and FGF receptor 2 (FGFR2) in nonsyndromic craniosynostosis by determining their temporospatial patterns of expression during development complicated by intrauterine head constraint. This study consisted of two groups of C57BI/6J mice: an experimental group subjected to intrauterine constraint and a control unconstrained group. Fetal head constraint was induced by performing uterine cerclage on day 17.5 of gestation and allowing intrauterine fetal growth to continue 24 and 48 hours beyond the normal gestational period. Control animals underwent hysterotomy on day 17.5 and the nonconstrained pups were allowed to continue intra-abdominal fetal growth 48 hours beyond normal gestation. Expression of TGF-beta receptor types I and II, and FGFR2 in the calvarial tissue was determined by immunohistochemical analysis. In the unconstrained control animals, there was minimal immunoreactivity for both TGF-beta receptors and FGFR2 within the coronal suture. After 24 hours of constraint, however, there was a marked increase in immunoreactivity of TGF-beta receptors and FGFR2 in the osteoblasts along the osteogenic fronts and in the dural cells. After 48 hours, there was continued expression of both type I and type II receptors and FGFR2 within the midsutural mesenchyme of the coronal suture, in the osteoblasts, and in the dura. The authors demonstrated substantial upregulation of TGF-beta receptor types I and II and FGFR2 in coronal sutures subjected to in utero constraint. These results suggest an important role for TGF-beta/TGF-beta receptor, and FGF/FGFR signaling in the pathogenesis of constraint-induced craniosynostosis.

journal_name

Ann Plast Surg

authors

Hunenko O,Karmacharya J,Ong G,Kirschner RE

doi

10.1097/00000637-200105000-00015

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

546-53; discussion 553-4

issue

5

eissn

0148-7043

issn

1536-3708

journal_volume

46

pub_type

杂志文章
  • Aesthetic surgery performed by plastic surgery residents: an analysis of safety and patient satisfaction.

    abstract:BACKGROUND:Aesthetic surgery is an integral component of plastic surgery. Despite its importance, adequate training in aesthetic surgery is met with challenges. Although the educational benefit of resident clinics has been demonstrated, such clinics are rarely found outside the United States. The objective of the prese...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e31828d7090

    authors: Koulaxouzidis G,Momeni A,Simunovic F,Lampert F,Bannasch H,Stark GB

    更新日期:2014-12-01 00:00:00

  • Madelung Disease Affecting Scrotal Region.

    abstract::Madelung disease is an uncommon disease characterized by large subcutaneous adipose masses. Mediterranean countries show higher disease incidence. We review the current concepts concerning this pathology, including etiology, diagnosis, and treatment. Madelung disease usually affects the upper half of the body, but we ...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SAP.0000000000000714

    authors: da Costa JN,Gomes T,Matias J

    更新日期:2017-01-01 00:00:00

  • Compression neuropathy of the ulnar digital nerves in the thumbs of a massage therapist.

    abstract::Compression neuropathies of digital nerves, caused by hypertrophied or anomalous muscles, are rare compared with such occurrences above the wrist. We reported a case of compression neuropathy of the ulnar digital nerves in bilateral thumbs of a massage therapist. Entrapment of the digital nerves by the hypertrophied f...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e31826a1607

    authors: Chen CC,Chien HF,Chen CL

    更新日期:2014-01-01 00:00:00

  • Influence of Cdp-Choline Administration on Early Burn Edema in Rats.

    abstract:PURPOSE:The cholinergic anti-inflammatory pathway may play an important role in early burn edema. Therefore, we evaluated the influence of cdp-choline on early systemic burn edema and leukocyte activation in shock in rat mesenteries after burn plasma transfer. METHODS:Burn plasma harvested from donor rats 4 hours afte...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000000605

    authors: Hernekamp JF,Hu SX,Schmidt VJ,Vogelpohl J,Kneser U,Kremer T

    更新日期:2015-10-01 00:00:00

  • Management of Incidental Hernia Discovered During Abdominal Contouring in Post-Bariatric Surgery Patients.

    abstract:PURPOSE:An increase in bariatric surgery has led to a rise in postbariatric contouring procedures. Despite a comprehensive preoperative assessment, body habitus in these patients may significantly limit the abdominal exam. Abdominal contouring procedures typically elevate large portions of the skin and fat off the abdo...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000001546

    authors: Levy AS,Dinesh A,Ahmed L,Morrison N,Engdahl R

    更新日期:2018-11-01 00:00:00

  • Nasal reconstruction after severe facial burns using a local turndown flap.

    abstract::Reconstruction of the nose after severe burn injury is a challenging problem. There are usually associated facial burns, which limits the availability of local flaps. Reconstruction with unburned distant tissue is often not appropriate because of the resulting mismatch in color and texture. Successful nasal reconstruc...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e31817d87ed

    authors: Taylor HO,Carty M,Driscoll D,Lewis M,Donelan MB

    更新日期:2009-02-01 00:00:00

  • Aesthetic treatment of the columella.

    abstract::Through a transfixion incision, a rhomboidal portion of both the depressor muscle of the nasal septum and the orbicular muscle of the mouth are excised. The remaining columellar tissues are brought nearer to each other by means of a mattress suture tied over a double-foam bolus. This simple procedure yields three adva...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198905000-00001

    authors: Cachay-Velásquez H,Laguinge RE

    更新日期:1989-05-01 00:00:00

  • Accuracy of High-Resolution Ultrasonography in the Detection of Extensor Tendon Lacerations.

    abstract:BACKGROUND:Lacerations to the extensor mechanism are usually diagnosed clinically. Ultrasound (US) has been a growing diagnostic tool for tendon injuries since the 1990s. To date, there has been no publication establishing the accuracy and reliability of US in the evaluation of extensor mechanism lacerations in the han...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000000524

    authors: Dezfuli B,Taljanovic MS,Melville DM,Krupinski EA,Sheppard JE

    更新日期:2016-02-01 00:00:00

  • Anterolateral thigh flap for trauma reconstruction.

    abstract::High velocity injuries have traditionally been covered with free muscle flaps. We sought to evaluate the utility of the anterolateral thigh flap (ALT) flap as a primary choice in reconstructing traumatic injuries in Western patients.A retrospective chart review was conducted of 122 patients treated at the R Adams Cowl...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e3181a20ab0

    authors: Lee JC,St-Hilaire H,Christy MR,Wise MW,Rodriguez ED

    更新日期:2010-02-01 00:00:00

  • Tensor fascia lata myocutaneous flap in lower abdominal wall reconstruction.

    abstract::The tensor fascia lata myocutaneous flap provides a reliable autogenous building block for anatomical lower abdominal wall reconstruction. Preservation of innervation allows maintenance of voluntary motor control and protective sensation. The excellent blood supply of this flap is particularly helpful in reconstructin...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198108000-00014

    authors: White DN,Pearl RM,Laub DR,DeFiebre BK

    更新日期:1981-08-01 00:00:00

  • Histological changes of the voice tube and possible clinical consequences after voice reconstruction with free ileocolon flap.

    abstract::Free ileocolon flap has become a valid option for restoration of speech after pharyngolaryngectomy. After transfer, deprivation of the trophic intestinal contents and exposure to chronic intermittent airflow could substantially modify the structure of the voice tube, compromising its function. Biopsy specimens from 14...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e31824680a9

    authors: Gharb BB,Rampazzo A,Hsu CT,Bassetto F,Spanio di Spilimbergo S,Chen HC

    更新日期:2013-07-01 00:00:00

  • Primary breast reconstruction with a subpectoral silicone tissue expander.

    abstract::A Silastic tissue expander inserted subpectorally at the time of modified radical mastectomy has provided early development of the reconstructive envelope, thereby simplifying matching of the contralateral breast. Significant emotional support for the woman faced with imminent loss of her breast has been repeatedly ob...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198511000-00007

    authors: Paul MD

    更新日期:1985-11-01 00:00:00

  • Intraosseous wiring in toe-to-hand transplantation.

    abstract::Although there are many reports on bony fixations in finger replantations, information pertaining to fixation methods in toe-to-hand transplantations is scarce. The results of intraosseous wiring were evaluated in 68 toe-to-hand transplantations in 47 patients. Clinical and radiological evaluation of bony union was co...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199507000-00013

    authors: Yim KK,Wei FC

    更新日期:1995-07-01 00:00:00

  • Posttraumatic epidermal inclusion cyst of the deep infratemporal fossa.

    abstract::The authors report a case of an epidermal inclusion cyst found in the deep infratemporal fossa 12 years after the patient sustained blunt trauma to that region. Posttraumatic epidermal inclusion cysts are rare and occur mainly in the fingers, palms, and soles. Introduction of the epidermal elements into the dermis dur...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-200101000-00015

    authors: Acarturk TO,Stofman GM

    更新日期:2001-01-01 00:00:00

  • Use of the osteomuscular dorsal scapular flap in the reconstruction of mandibular defects.

    abstract::The gold standard for mandibular defect reconstruction is the fibular free flap. Nevertheless, the pedicled osteomuscular dorsal scapular flap as a reconstructive tool offers promise for mandibular defect reconstruction and could be the first choice in certain circumstances. Its use in resource-limited settings offers...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e318230992e

    authors: Nthumba PM

    更新日期:2013-01-01 00:00:00

  • Critical closing pressure, local perfusion pressure, and the failing skin flap.

    abstract::A simple apparatus was devised to perfuse the rat groin flap to study the relationship between perfusion pressure and flow. Results demonstrate that a relatively high intraarterial pressure must be applied to this skin flap before blood flow will commence. Results suggest that this critical closing phenomenon is the r...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198206000-00009

    authors: Cutting C,Ballantyne D,Shaw W,Converse JM

    更新日期:1982-06-01 00:00:00

  • Centripetal rotation-advancement for cleft lip nasal deformities.

    abstract::A technique for reconstruction of the bilateral cleft lip nose is described. The literature for bilateral cleft lip nasal repair and the use of autogenous cartilage grafts is reviewed. ...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-197905000-00003

    authors: Gorney M,Rosenberg HL

    更新日期:1979-05-01 00:00:00

  • Burn scar sarcoma.

    abstract::A case of malignant fibrous histiocytomas arising in a burn scar is described. Burn scar sarcomas are exceedingly rare tumors whose precise behavior, pathogenesis, and treatment remain to be elucidated. ...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198805000-00014

    authors: Gargan TJ,Mitchell L,Plaus W

    更新日期:1988-05-01 00:00:00

  • Utilization of the burn unit for nonburn patients: the "wound intensive care unit".

    abstract::Burn units and experienced burn nurses are valuable, expensive resources that are underutilized when the burn census is low. Burn facilities can be used to treat other conditions or injuries to provide optimum wound management or to provide overflow intensive care unit beds. We studied via a questionnaire survey the a...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198911000-00008

    authors: Barillo DJ,Hallock GG,Mastropieri CJ,Troiani YM,Knowlton C

    更新日期:1989-11-01 00:00:00

  • Locating perforator vessels by dynamic infrared imaging and flow Doppler with no thermal cold challenge.

    abstract:BACKGROUND:Dynamic Infrared Imaging (DIRI) is a noninvasive technique that precisely analyzes the infrared radiation of any object. We used this technique to locate the dominant perforator vessels in flap surgery in conjunction with conventional Doppler. METHODS:Ten patients scheduled for deep inferior epigastric arte...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e3181ef6da3

    authors: Tenorio X,Mahajan AL,Elias B,van Riempst JS,Wettstein R,Harder Y,Pittet B

    更新日期:2011-08-01 00:00:00

  • Surgical relations of the orbit and optic nerve: an anatomical study under magnification.

    abstract::Whether operating on soft tissue, bony tissue, or both, as in major craniofacial procedures, patient safety is enhanced by better understanding of the anatomical details of the orbit. The myth and mystery of the optic nerve is made clear here, especially by our magnification techniques. ...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198004000-00001

    authors: Habal MB,Maniscalco JE

    更新日期:1980-04-01 00:00:00

  • Island volar advancement flap for reconstruction of thumb defects.

    abstract:BACKGROUND:The volar advancement flap of the thumb described by Moberg has been used for pulp defects up to 1 to 1.5 cm since its mobility is quite limited due to the stiff nature and fibrous connections of the regional skin with underlying structures. There have been several attempts to increase the mobility of this u...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e318216e6b1

    authors: Mutaf M,Temel M,Günal E,Işık D

    更新日期:2012-02-01 00:00:00

  • A tailored approach to the surgical treatment of cubital tunnel syndrome.

    abstract::Multiple studies have compared the outcome of surgery for cubital tunnel syndrome (CUTS), yet there remains no clear guidelines for treatment. We describe an approach to CUTS that includes tailoring the procedure to the pathology found at surgery. Patients treated surgically were retrospectively reviewed. Following in...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e318219183d

    authors: Keith J,Wollstein R

    更新日期:2011-06-01 00:00:00

  • The management of pigmented lesions of the nail bed.

    abstract::Pigmented lesions of the nail bed, especially without a history of trauma, represent a diagnostic challenge to the clinician. These lesions are often categorized as melanonychia striata (MS), which refers to any linear tan-brown-black pigmentation of the nail bed. The differential diagnosis of MS includes subungual he...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199608000-00002

    authors: Glat PM,Spector JA,Roses DF,Shapiro RA,Harris MN,Beasley RW,Grossman JA

    更新日期:1996-08-01 00:00:00

  • Correction of blepharoptosis in oculopharyngeal muscular dystrophy.

    abstract::Oculopharyngeal muscular dystrophy is a hereditary, autosomal dominant, slowly progressive disorder with onset that occurs during middle age. Major symptoms are ptosis and dysphagia resulting primarily from selectively involved levator palpebrae and the pharyngeal muscles. Progressive, usually symmetrical blepharoptos...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-200210000-00015

    authors: Kang DH,Koo SH,Ahn DS,Park SH,Yoon ES

    更新日期:2002-10-01 00:00:00

  • Correction of frontal bone hypertrophy with setback osteotomy and hydroxyapatite cement.

    abstract::This case report illustrates a method of correction for severe hypertrophy of the frontal bone. Accurate preoperative assessment including physical examination, photographs, and radiological studies are necessary. The anterior table of the frontal bone is removed, recontoured, and stabilized to the adjacent bone while...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-200044050-00017

    authors: Nahabedian MY,Al-Shunnar B,Manson PN

    更新日期:2000-05-01 00:00:00

  • Reactive thrombocytosis without endothelial damage does not affect the microvascular anastomotic patency.

    abstract::There is still controversy about the correlation of thrombocytosis and thrombosis complication. Using a rodent splenectomy-induced thrombocytosis model and a thrombogenic endothelial damage model (inverted suture resulting in an intraluminal thrombogenic adventitia of divided femoral artery), the authors investigated ...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-200301000-00010

    authors: Kuo YR,Yang KD,Huang MN,Wei FC,Jeng SF

    更新日期:2003-01-01 00:00:00

  • Soft tissue reconstruction using vascularized tissue transplantation following resection of musculoskeletal sarcoma: evaluation of oncologic and functional outcomes in 55 cases.

    abstract::Oncologic resection of musculoskeletal sarcoma sometimes requires reconstruction with vascularized soft tissue transplantation. To date, few reports have described treatment outcomes of such cases. In the present study, 55 cases were enrolled to examine oncologic/functional outcomes, complications, and the risks for p...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e31817fe4b3

    authors: Morii T,Mochizuki K,Takushima A,Okazaki M,Satomi K

    更新日期:2009-03-01 00:00:00

  • Vein, silastic, and polyglycolic acid fine mesh: a comparative study in peripheral nerve repair.

    abstract::We investigated three sheathing materials (autogenous vein, silastic, and polyglycolic acid fine mesh) using the rat model. Forty rats were divided into five groups of eight animals each. Group A animals underwent transection of the sciatic nerve but had no repair. In Group B, a standard epineural repair was performed...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199509000-00008

    authors: Lolley RD,Bose WJ,Bastian F,Bassam B,Meyer FN,Anderson LD

    更新日期:1995-09-01 00:00:00

  • Internal mammary perforators as recipient vessels for deep inferior epigastric perforator and muscle-sparing free transverse rectus abdominis musculocutaneous flap breast reconstruction in an Asian population.

    abstract:BACKGROUND:The use of internal mammary perforators (IMPs) as recipient vessels in autologous free flap breast reconstruction has many additional benefits compared with the internal mammary or thoracodorsal vessels. Our goals were to analyze the characteristics of these vessels and to evaluate the reliability of using t...

    journal_title:Annals of plastic surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SAP.0b013e318270704b

    authors: Halim AS,Alwi AA

    更新日期:2014-08-01 00:00:00