Abdominal ventral hernia repair with current biological prostheses: an experimental large animal model.

Abstract:

:Biologic prostheses have emerged to address the limitations of synthetic materials for ventral hernia repairs; however, they lack experimental comparative data. Fifteen swine were randomly assigned to 1 of 3 bioprosthetic groups (DermaMatrix, AlloDerm, and Permacol) after creation of a full thickness ventral fascial defect. At 15 weeks, host incorporation, hernia recurrence, adhesion formation, neovascularization, inflammation, and biomechanical properties were assessed. No animals had hernia recurrence or eventration. DermaMatrix and Alloderm implants demonstrated more adhesions, greater inflammatory infiltration, and more longitudinal laxity, but near identical neovascularization and tensile strength to Permacol. We found that porcine acellular dermal products (Permacol) contain following essential properties of an ideal ventral hernia repair material: low inflammation, less elastin and stretch, lower adhesion rates and cost, and more contracture. The addition of lower cost xenogeneic acellular dermal products to the repertoire of available acellular dermal products demonstrates promise, but requires long-term clinical studies to verify advantages and efficacy.

journal_name

Ann Plast Surg

authors

Stanwix MG,Nam AJ,Hui-Chou HG,Ferrari JP,Aberman HM,Hawes ML,Keledjian KM,Jones LS,Rodriguez ED

doi

10.1097/SAP.0b013e3181e051ed

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

403-9

issue

4

eissn

0148-7043

issn

1536-3708

journal_volume

66

pub_type

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