A model of chronic nerve compression in the rat.

Abstract:

:This article describes a model of chronic nerve compression in the rat. The sciatic nerve of adult male Sprague Dawley rats was banded with a 1-cm Silastic tube for varying periods of time. Morphometric analysis, electrodiagnostic studies, and histological evaluation were carried out 3, 5, 8, and 12 months after banding. Histological evaluation at 3 months was normal. At 5 months perineurial thickening was demonstrated. In the periphery of the fascicles, segmental demyelination was noted; central fibers appeared normal. At 8 months there was further epineurial and perineurial thickening. Marked thinning of the myelin was noted in all fibers and evidence of Wallerian degeneration was apparent. Progressive connective tissue and nerve fiber changes were noted at 12 months. Nerve conduction studies after 3 months of compression demonstrated an increase in conduction velocity compared to the normal unbanded control nerves. Progressive slowing of conduction velocity was noted from 5 through 12 months.

journal_name

Ann Plast Surg

authors

O'Brien JP,Mackinnon SE,MacLean AR,Hudson AR,Dellon AL,Hunter DA

doi

10.1097/00000637-198711000-00008

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

430-5

issue

5

eissn

0148-7043

issn

1536-3708

journal_volume

19

pub_type

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