Endothelin-1 kinetics in plasma, urine, and blister fluid in burn patients.

Abstract:

:Endothelin-1, a peptide isolated from vascular endothelial cells, facilitates the constriction of vascular smooth muscle and various pharmacological actions including vasodilation, the proliferation of smooth muscle cells and fibroblasts, and the stimulation of arachidonic acid metabolism. In this study, plasma, urine, and blister fluid endothelin-1 concentrations were determined in burn patients and changes in vasoactive substances derived from endothelial cells secondary to burns were investigated. Plasma endothelin-1 concentrations in burn patients were significantly lower than those in healthy individuals at rest. However, extremely high blister fluid endothelin-1 concentrations were observed within 30 hours of a burn. The amounts of endothelin-1 excreted in urine by burn patients over 24 hours also were higher than those in healthy individuals. The finding of high concentrations of endothelin-1 in blister fluids suggests that endothelin-1 is produced at wound regions in burn victims. Clinically, it appears that endothelin-1 is involved in circulation at the wound surface or in the healing of burns.

journal_name

Ann Plast Surg

authors

Wakisaka N,Kubota T,Ando K,Aihara M,Inoue H,Ishida H

doi

10.1097/00000637-199609000-00012

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

305-9

issue

3

eissn

0148-7043

issn

1536-3708

journal_volume

37

pub_type

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