Prevalence and Fluconazole Susceptibility Profile of Candida spp. Clinical Isolates in a Brazilian Tertiary Hospital in Minas Gerais, Brazil.

Abstract:

:Candidiasis has become an important concern for clinical practice, especially with the increasing incidence of immunocompromised patients. In this scenario, the development resistance to fluconazole presents a challenge for treating these opportunistic infections. The aim of this study was to evaluate some epidemiology features of Candida infections in a Brazilian University Hospital using data, previously unavailable. We observed that 44% of the 93 clinical isolates tested, belonged to Candida albicans species and 56% belonged to non-Candida albicans species (mainly Candida tropicalis and Candida glabrata). Most strains were isolated from urine samples where C. albicans was predominantly detected. 29 strains presented a fluconazole resistance phenotype and of these, 22 were chemosensitised by FK506, a classical inhibitor of ABC transporters related to azoles resistance. These data suggest the probable role of efflux pumps in this resistance phenotype. Our study highlights the need for developing effective control measures for fungal infections, rational use of antifungal drugs and development of new molecules able to abrogate the active transport of antifungals.

journal_name

An Acad Bras Cienc

authors

Neves-Junior A,Cartágenes-Pinto AC,Rocha DA,de Sá LF,Junqueira Mde L,Ferreira-Pereira A

doi

10.1590/0001-3765201520140717

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

1349-59

issue

2 Suppl

eissn

0001-3765

issn

1678-2690

pii

S0001-37652015005040717

journal_volume

87

pub_type

杂志文章
  • Growth and intestinal morphology of juvenile pacu Piaractus mesopotamicus (Holmberg 1887) fed dietary prebiotics (mannanoligosaccharides - MOS).

    abstract::Intensification of aquaculture production systems exposes fish to numerous stressors, which may negatively affect their growth and limit profitability of aquaculture systems. This study determined effects of increasing levels of dietary mannanoligosaccharides on growth and intestine morphology of pacu. Fish (44.04 g) ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201420130088

    authors: Sado RY,Bicudo AJ,Cyrino JE

    更新日期:2014-09-01 00:00:00

  • Metabolic responses to dietary carbohydrate/lipids ratios in neotropical hybrid catfish (♂Pseudoplatystoma corruscans×♀Pseudoplatystoma fasciatum).

    abstract::The purpose of this study was to assess the effect of different carbohydrate and lipid (CHO/L) ratios on the performance and energy metabolism of hybrid catfish (♂Pseudoplatystoma corruscans × ♀ Pseudoplatystoma fasciatum). One hundred and sixty-eight fish (104.9±16.5 g BW) were distributed into 24 100-L tanks. The ex...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920190075

    authors: Okamura D,Fortes-Silva R,Paulino RR,Araújo FG,Costa DVD,Pereira RT,Rosa PV

    更新日期:2019-11-25 00:00:00

  • Effects of maternal artificial vocalization on hyperprolific lactating sows and piglets behavior.

    abstract::The objective of this trial was to evaluate the behavioral patterns and performance of lactating sows and their litters under the effect of artificial vocalization. Twenty-eight sows and their litters were distributed in a completely randomized design in a 2x2 factorial scheme (artificial vocalization x lactation week...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820180340

    authors: Moreira RHR,Oliveira RF,Palencia JYP,Lemes MAG,Silva MD,Garbossa CAP,Abreu MLT,Moura GB,Ferreira RA

    更新日期:2018-10-01 00:00:00

  • Richness and abundance of the cardini group of Drosophila (Diptera, Drosophilidae) in the Caatinga and Atlantic Forest biomes in northeastern Brazil.

    abstract::Brazil has a high diversity of flies of the genus Drosophila, and part of this richness is represented by the cardini group. We analyzed the fluctuations in the richness and abundance of this group, in environments that had never previously been studied in the northeastern region of Brazil. Among the 28,204 drosophili...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201420130314

    authors: Rohde C,Silva DM,Oliveira GF,Monteiro LS,Montes MA,Garcia AC

    更新日期:2014-12-01 00:00:00

  • Potentially mobile of heavy metals on the surface sediments in tropical hyper-saline and positive estuaries.

    abstract::Estuarine sediments represent important pools of trace metals, released from both anthropogenic and natural sources. Fluctuations in the water column physicochemical conditions, on the other hand, may transfer metals from solid to liquid compartment and resulting in contamination of the surrounding environment. The pr...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720170110

    authors: Silva CARE,Fonseca EMD,Grotto BW,Souza FES,Baptista JA Neto

    更新日期:2017-10-01 00:00:00

  • Population structure and allometry of Podocnemis unifilis (Testudines, Podocnemididae) in a protected area upstream Belo Monte dam in Xingu River, Brazil.

    abstract::Amazon river turtles are increasingly threatened by habitat loss and alteration due to the Brazilian energy policy based on construction of hydroelectric dams, meanwhile, populational studies remain scarce. We described the population structure, and established body allometric relationships of Podocnemis unifilis in t...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140321

    authors: Miorando PS,Giarrizzo T,Pezzuti JC

    更新日期:2015-10-01 00:00:00

  • Bioethanol production with different dosages of the commercial Acrylamide polymer compared to a Bioextract in clarifying sugarcane juice.

    abstract::One of the most important steps is to clarify the juice, which are added synthetic polymer acrylamide base, aiming the fast settling of impurities present in the juice. However, this input is expensive and may have carcinogenic and neurotoxic actions to humans. The search for new natural flocculants that have similari...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720170473

    authors: Freita CM,Freita LA,Tralli LF,Silva AF,Mendes FQ,Teixeira V,Mutton MJR

    更新日期:2017-10-01 00:00:00

  • Genetic parameters for performance and carcass traits in a paternal 1 lineage of broiler.

    abstract::The objective of this study was to estimate variance components for performance and carcass traits in a paternal broiler line. The (co)variance components were estimated by the restricted maximum likelihood method applied to the animal model, including the fixed effect of group (sex and hatch) and additive genetic and...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020180697

    authors: Cruz VAR,Grupioni NV,Mendonça GG,Venturini GC,Ledur MC,Peixoto JO,Munari DP

    更新日期:2020-01-01 00:00:00

  • Bromophenol concentrations in fish from Salvador, BA, Brazil.

    abstract::The main objective of this work is to evaluate the occurrence of bromophenols (2bromophenol, 4bromophenol, 2,4dibromophenol, 2,6dibromophenol and 2,4,6tribromophenol), in the flesh and guts in two species of the LutjanidaeFamily: Lutjanus synagris and Ocyurus chrysurus. The bromophenols were extracted by steam distill...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000200002

    authors: Oliveira AS,Silva VM,Veloso MC,Santos GV,Andrade JB

    更新日期:2009-06-01 00:00:00

  • Consumption of Euterpe edulis fruit by wildlife: implications for conservation and management of the Southern Brazilian Atlantic Forest.

    abstract::This study aimed to measure the wildlife consumption of Euterpe edulis fruit and use this data to discuss management possibilities. To estimate infructescence fruit volume consumed, collectors were installed in fruit-bearing palms. To characterize consumption from the ground, samples were placed next to fruiting palms...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180537

    authors: Silva JZD,Reis MSD

    更新日期:2019-01-01 00:00:00

  • Tephritidae flies associated with Chuquiraga avellanedae (Asteraceae) in Patagonia, Argentina.

    abstract::In Patagonia, knowledge about the interaction among tephritids and the native flora is very scarce. In this study we identified for the first time two tephritid species (Cecidochares sp. and Neosphaeniscus m-nigrum) associated with the capitula of Chuquiraga avellanedae. This is the first record of a host plant for th...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020191524

    authors: Martinez FJ,Norrbom AL,Schliserman P,Campanella MV

    更新日期:2020-10-12 00:00:00

  • Influence of the nycthemeral cycle on the roosting behaviour of the Orange-winged Amazon.

    abstract::Environmental stimuli exert important effects on the expression of the endogenous rhythms. Daily movements of groups of parrots in response to the light/dark cycle have been studied by several researchers. However, the factors modifying the intrinsic rhythmicity of this behaviour remain little known. This study descri...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012005000029

    authors: Moura LN,Silva ML,Vielliard JM

    更新日期:2012-06-01 00:00:00

  • Electrocyte physiology: I. Temperature dependence of membrane excitability.

    abstract::Some membrane characteristics of the isolated electrocyte of the Sachs organ are presented as function of temperature. Excitability curves are shown for electrocytes kept in standard saline at different temperatures. It is shown that rheobase varies directly with temperature. Apparently membrane resistance varies from...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Esquibel MA,Negreiros J,Gawryszewski LG

    更新日期:1980-09-01 00:00:00

  • Cyanobacterial blooms in stratified and destratified eutrophic reservoirs in semi-arid region of Brazil.

    abstract::This study investigated the dynamics of cyanobacteria in two deep, eutrophic reservoirs in a semi-arid region of Brazil during periods of stratification and destratification. Four collections were carried out at each reservoir at two depths at three-month intervals. The following abiotic variables were analyzed: water...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652011000400019

    authors: Dantas EW,Moura AN,Bittencourt-Oliveira Mdo C

    更新日期:2011-12-01 00:00:00

  • Uncertainties Associated with Arithmetic Map Operations in GIS.

    abstract::Arithmetic map operations are very common procedures used in GIS to combine raster maps resulting in a new and improved raster map. It is essential that this new map be accompanied by an assessment of uncertainty. This paper shows how we can calculate the uncertainty of the resulting map after performing some arithmet...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170589

    authors: Yamamoto JK,Kikuda AT,Rampazzo GJ,Leite CBB

    更新日期:2018-08-01 00:00:00

  • Antiproliferative effect of guava fruit extracts in MDA-MB-435 and MCF-7 human breast cancer cell lines.

    abstract::Breast cancer is the most frequent and lethal neoplastic disease among women worldwide. Psidium Guajava is a promising functional food against cancer, owing to a variety of bioactive compounds. This study aimed to evaluate the anticarcinogenic potential of Pedro Sato (PS), Hitigio (HI) and Tsumori (TS) guava cultivars...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020191500

    authors: Correa MG,Couto JS,Trindade BB,Abreu JP,Nakajima VM,Oliveira FL,Farah A,Teodoro AJ

    更新日期:2020-01-01 00:00:00

  • The theorical-methodological construction of theses and dissertations and their epistemological problems.

    abstract::This essay discusses the problem of the lack of dialogue between theory/empirical reality in the construction of the theoretical structure of dissertations and doctorates in Human Sciences in Brazil; taking Geography as an example, Santos (2000) observed this problem, which persists at the national level. The proposal...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920171020

    authors: Gomes RD

    更新日期:2019-01-01 00:00:00

  • Interspecific variation in leaf pigments and nutrients of five tree species from a subtropical forest in southern Brazil.

    abstract::The purpose of this study was to analyze the seasonal variation in the nutrient and pigment content of leaves from five tree species - of which three are perennial (Cupania vernalis, Matayba elaeagnoides and Nectandra lanceolata) and two are deciduous (Cedrela fissilis and Jacaranda micrantha) - in an ecotone between ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620140605

    authors: Bündchen M,Boeger MR,Reissmann CB,Geronazzo KM

    更新日期:2016-01-01 00:00:00

  • The exotic wasp Megastigmus transvaalensis (Hymenoptera: Torymidae): first record and damage on the Brazilian peppertree, Schinus terebinthifolius drupes, in São Paulo, Brazil.

    abstract::This paper records the first report of Megastigmus transvaalensis Hussey (Hymenoptera: Torymidae) in Brazilian peppertree, Schinus terebinthifolius Raddi (Anacardiaceae) drupes in Sorocaba, state of São Paulo, Brazil. This wasp is an invasive species and was found damaging S. terebinthifolius drupes in urban areas (35...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140478

    authors: Ferreira-Filho PJ,Piña-Rodrigues FC,Silva JM,Guerreiro JC,Ghiotto TC,Piotrowski I,Dias LP,Wilcken CF,Zanuncio JC

    更新日期:2015-10-01 00:00:00

  • The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks.

    abstract::Long-term potentiation (LTP) is the enhancement of postsynaptic responses for hours, days or weeks following the brief repetitive afferent stimulation of presynaptic afferents. It has been proposed many times over the last 30 years to be the basis of long-term memory. Several recent findings finally supported this hyp...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652008000100007

    authors: Izquierdo I,Cammarota M,Da Silva WC,Bevilaqua LR,Rossato JI,Bonini JS,Mello P,Benetti F,Costa JC,Medina JH

    更新日期:2008-03-01 00:00:00

  • Semi-automated counting model for arbuscular mycorrhizal fungi spores using the Circle Hough Transform and an artificial neural network.

    abstract::Arbuscular Mycorrhizae (AM) are mutualistic associations between Arbuscular Mycorrhizal Fungi (AMF) and the roots of many plant species. AMF spores give rise to filaments that develop in the root system of plants and contribute to the absorption of water and some nutrients. This article introduces a semi-automated cou...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180165

    authors: Melo CAO,Lopes JG,Andrade AO,Trindade RMP,Magalhães RS

    更新日期:2019-10-21 00:00:00

  • Entry, dispersion and differentiation of microglia in the developing central nervous system.

    abstract::Microglial cells within the developing central nervous system (CNS) originate from mesodermic precursors of hematopoietic lineage that enter the nervous parenchyma from the meninges, ventricular space and/or blood stream. Once in the nervous parenchyma, microglial cells increase in number and disperse throughout the C...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/s0001-37652000000100013

    authors: Navascués J,Calvente R,Marín-Teva JL,Cuadros MA

    更新日期:2000-01-01 00:00:00

  • Antipsychotic profile of alstonine: ethnopharmacology of a traditional Nigerian botanical remedy.

    abstract::Although recently developed drugs have brought significant improvement, the treatment of psychotic disorders still presents serious drawbacks. Since inherent complexity and lack of satisfactory understanding of the underlying pathophysiology impose limits for rational drug design, resourceful approaches in the search ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Costa-Campos L,Elisabetsky E,Lara DR,Carlson TJ,King SR,Ubillas R,Nunes DS,Iwu MM,Nkemjika CO,Ozioko A,Agwu CO

    更新日期:1999-01-01 00:00:00

  • Annual, seasonal and spatial abundance of the seabob shrimp Xiphopenaeus kroyeri (Decapoda, Penaeidae) off the Southeastern coast of Brazil.

    abstract::We investigated the influence of environmental factors in spatial and temporal distribution of the seabob shrimp Xiphopenaeus kroyeri in Santos Bay and São Vicente Estuary, state of São Paulo, Brazil. Monthly samples were obtained, from May 2008 through April 2010, from four locations in the estuary and four in the ba...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201420130230

    authors: Heckler GS,Lopes M,Simões SM,Shimizu RM,Costa RC

    更新日期:2014-09-01 00:00:00

  • Identification of caffeic acid and rutin by UHPLC MS/MS and antioxidant activity of Commelina erecta Lineu. in cell culture.

    abstract::The Commelina erecta L. (C. erecta) also known as erva-de-santa-luzia is reported by local population to have medical properties against some pathological conditions. In this study, two extracts of C. erecta leaves (aqueous and ethanolic) were phytochemically analysed and evaluated for their in-vitro antioxidant activ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020190491

    authors: Otsuka FAM,Santos RB,Chaves LF,Santos RS,Chaves Filho AB,Miyamoto S,Matos HR

    更新日期:2020-01-01 00:00:00

  • [The use of tapioca as coverage in viral titration].

    abstract::Virus titration is an important step required on viral vaccines quality control. "Plaque assay", which employs several types of overlay media, is usually used on viral titrations. In this paper we describe the use of Tapioca as an overlay media. Firstly, the toxicity of Tapioca was tested on Vero cells inoculated or n...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Post PR,de Carvalho R,Brito EC,Galler R

    更新日期:1992-01-01 00:00:00

  • Voltammetric characteristics of miconazole and its cathodic stripping voltammetric determination.

    abstract::Miconazole is reduced at mercury electrode above pH 6 involving organometallic compound formation, responsible for an anomalous polarographic behavior. The electrodic process presents a large contribution of the adsorption effects. The drug can be determined by cathodic stripping voltammetry from 8.0 x 10(-8) to 1, 5 ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652002000300005

    authors: Pereira FC,Stradiotto NR,Zanoni MV

    更新日期:2002-09-01 00:00:00

  • Radiopharmaceuticals drug interactions: a critical review.

    abstract::Radiopharmaceuticals play a critical role in modern medicine primarily for diagnostic purposes, but also for monitoring disease progression and response to treatment. As the use of image has been increased, so has the use of prescription medications. These trends increase the risk of interactions between medications a...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/s0001-37652008000400008

    authors: Santos-Oliveira R,Smith SW,Carneiro-Leão AM

    更新日期:2008-12-01 00:00:00

  • Trophic ecology of the intertidal sea anemone Bunodosoma zamponii (Cnidaria, Actiniaria): diet composition, seasonal variation and trophic parameters.

    abstract::Sea anemones are considered as polyphagous opportunistic predators and it has been suggested that their diet reflects the structure of the community they inhabit. The feeding ecology of intertidal species is an interesting topic to study due to their wide variety of strategies to obtain food. In this sense, we studied...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020190520

    authors: Erralde SM,AcuÑa FH

    更新日期:2020-10-19 00:00:00

  • The classic episode of biological invasion: Cochliomyia macellaria (Fabricius, 1775) versus Chrysomya megacephala (Fabricius, 1794) (Diptera: Calliphoridae) - evaluation of the biotic potential.

    abstract::The classic episode of biological invasion: Cochliomyia macellaria (Fabricius, 1775) versus Chrysomya megacephala (Fabricius, 1794) (Diptera: Calliphoridae) - evaluation of the biotic potential. The biotic of the native fly Cochliomyia macellaria and the exotic Chrysomya megacephala was compared, through the reproduct...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150270

    authors: Barbosa LS,Couri MS,Coelho VM,Avelino-Capistrano F

    更新日期:2016-09-01 00:00:00