Expressions of matrix metalloproteinases-1 and -9 and opioid growth factor in rabbit cornea after lamellar keratectomy and treatment with 1% nalbuphine.

Abstract:

PURPOSES:To evaluate the effects of nalbuphine 1% on the expression of metalloproteinase 1 (MMP-1), metalloproteinase 9 (MMP-9), and opioid growth factor (OGF) in rabbit corneas after lamellar keratectomy. METHODS:The rabbits were assigned to two groups: group nalbuphine (GN, n=30), which received 30 µL of nalbuphine 1% in 4 daily applications at regular intervals until corneal epithelialization, and group control (GC, n=30), which received physiological saline solution under the same conditions adopted in GN. The corneas were collected for immunohistochemistry on days 1, 3, 5, 7, and 9 after lamellar keratectomy, and the expressions of MMP-1, MMP-9, and OGF were analyzed. RESULTS:The expressions of MMP-1 and MMP-9 increased until day 5 of the evaluation, with no differences observed between GN and GC (p>0.05). On days 7 and 9, significant reductions were observed in the expression of MMP-1 (p<0.01), with no differences observed between GN and GC (p>0.05). The expression of OGF was constant in all periods (p>0.05), restricted to the corneal epithelium, and there was no difference between the groups (p>0.05). CONCLUSIONS:The study results showed that nalbuphine 1% did not alter the expression patterns of MMP-1, MMP-9, and OGF in rabbit corneas after lamellar keratectomy.

journal_name

Arq Bras Oftalmol

authors

Silva ML,Ribeiro AP,Silva GA,Sanchez IX,Renzo R,Uscategui R,Lima TB,Aldrovani M,Laus JL

doi

10.5935/0004-2749.20150037

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

141-5

issue

3

eissn

0004-2749

issn

1678-2925

pii

S0004-27492015000300002

journal_volume

78

pub_type

杂志文章
  • Approach of Turkish ophthalmologists to micronutrition in age-related macular degeneration.

    abstract:PURPOSE:To evaluate the knowledge and behaviors of ophthalmologists in Turkey concerning micronutrition support in patients with age related macular degeneration (ARMD). METHODS:This study involved 1,845 ophthalmologists. A scientific poll was sent to all participants by email. The survey covered the following: demogr...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.5935/0004-2749.20150004

    authors: Muhammed Ş,Yüksel H,Şahin A,Cingü AK,Türkcü FM,Özkurt ZG,Çaça İ

    更新日期:2015-01-01 00:00:00

  • [Optical coherence tomography macular study on eyes filled with silicone oil].

    abstract:PURPOSE:To demonstrate optical coherence tomography efficacy to evaluate macular anatomical outcomes, in eyes with silicone oil-filled vitreous cavity after vitrectomy. METHODS:A descriptive observational study of 28 (twenty-eight) patients submitted to pars plana vitrectomy having silicone oil as vitreous substitute....

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492007000200017

    authors: Maia OO Jr,Takahashi WY,Nakashima Y,Primiano Júnior HP,Takahashi BS,Nakashima AF

    更新日期:2007-03-01 00:00:00

  • Experimental models of autoimmune inflammatory ocular diseases.

    abstract::Ocular inflammation is one of the leading causes of blindness and loss of vision. Human uveitis is a complex and heterogeneous group of diseases characterized by inflammation of intraocular tissues. The eye may be the only organ involved, or uveitis may be part of a systemic disease. A significant number of cases are ...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,评审

    doi:10.1590/s0004-27492012000200016

    authors: Gasparin F,Takahashi BS,Scolari MR,Gasparin F,Pedral LS,Damico FM

    更新日期:2012-03-01 00:00:00

  • [Trends on anophthalmic socket repair in Brazil].

    abstract:PURPOSE:To determine the most common approach to repair the anophthalmic socket in Brazil, and to compare the data with the trends in other countries. METHODS:Exploratory study using electronic questionnaire sent by Internet to ophthalmologists members of the Brazilian Orbit and Oculoplastic Society (SBCPO). The recei...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492012000600004

    authors: Sousa RL,Schellini SA,Zornoff Dde C,Padovani CR

    更新日期:2012-11-01 00:00:00

  • [Pediatric cataract in a developing country: retrospective review of 328 cases].

    abstract:INTRODUCTION:Pediatric cataracts constitute an important cause of low visual acuity. PURPOSE:The objective of the present work is to know the characteristics of this pathology in an ophthalmic attention unit of a developing country. METHODS:A retrospective, descriptive, transversal study was carried out in 328 cases ...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492011000300003

    authors: Zimmermann-Paiz MA,Quiroga-Reyes CR

    更新日期:2011-05-01 00:00:00

  • [Sight-threatening orbital emphysema after nose blowing: case report].

    abstract::Orbital emphysema is the abnormal presence of air in the orbit. Occurrence in the absence of orbital fracture is rare. We report a case of a 40-year-old female presenting unilateral orbital emphysema after vigorous nose blowing. She developed sudden visual loss as a result of elevated intraocular pressure and urgent t...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492009000200024

    authors: Furlani Bde A,Diniz B,Bitelli LG,Martins EN

    更新日期:2009-03-01 00:00:00

  • [Occupational trauma due to superficial corneal foreign body].

    abstract:PURPOSE:To evaluate the epidemiology of superficial corneal foreign body. METHODS:Patients who were seen at the Emergency Service of the Federal University of São Paulo, from April/05 to June/05, were screened and those with superficial corneal foreign body were interviewed. Data regarding gender, age, occupation, emp...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492008000200004

    authors: Gerente VM,Melo GB,Regatieri CV,Alvarenga LS,Martins EN

    更新日期:2008-03-01 00:00:00

  • Solitary fibrous tumor of the lacrimal gland mimicking pleomorphic adenoma.

    abstract::Solitary fibrous tumor (SFT) is a rare mesenchymal spindle-cell neoplasm commonly found in the pleura; it is rare in the orbit and extremely rare in the lacrimal gland. We herein report a case of SFT of the lacrimal gland that mimicked a pleo morphic adenoma. We discuss the clinical, radiological, histopathological, a...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.5935/0004-2749.20170046

    authors: Feijó ED,Nery ACS,Caiado FR,Limongi RM

    更新日期:2017-06-01 00:00:00

  • Postconceptional age at the treatment of retinopathy of prematurity in inborn and referred preterm infants from the same institution.

    abstract:PURPOSE:The outcomes of the treatment of retinopathy of prematurity (ROP) seem to be better in inborn patients than in those patients who were referred for ROP treatment. This study aims to investigate the timing of treatment and the outcomes in inborn patients and in patients referred for treatment to the Hospital de ...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492011000400004

    authors: Fortes Filho JB,Eckert GU,Valiatti FB,Santos PG,Costa MC,Procianoy RS

    更新日期:2011-07-01 00:00:00

  • New insights into Vogt-Koyanagi-Harada disease.

    abstract::Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the ...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,评审

    doi:10.1590/s0004-27492009000300028

    authors: Damico FM,Bezerra FT,Silva GC,Gasparin F,Yamamoto JH

    更新日期:2009-05-01 00:00:00

  • Choroidal metastasis as the first sign of bronchioloalveolar lung cancer: case report.

    abstract::Metastatic tumors are the most common intraocular malignances and choroid is by far the most common site. Breast and lung cancer are the first cause in women and men respectively. We report the case of a 71-year old woman who had choroidal tumor in her left eye. Further image body scans demonstrated several lesions in...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492013000400014

    authors: Aragão RE,Barreira IM,Gomes LM,Bastos AS,Beserra Fde F

    更新日期:2013-07-01 00:00:00

  • Focal phototherapeutic keratectomy for the treatment of apical leucoma syndrome.

    abstract::The following report describes a case of apical leucoma syndrome after hyperopic photorefractive keratectomy following hyperopic laser in situ keratomileusis and the subsequent treatment of this complication with focal phototherapeutic keratectomy. The patient underwent focal transepithelial phototherapeutic keratecto...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 信件

    doi:10.5935/0004-2749.20180068

    authors: Ghanem VC,Passos ML,Piccinini AL,Ghanem RC

    更新日期:2018-07-01 00:00:00

  • [Eyelid ectropium prevalence and carriers characteristics in a population from the Center-Western region of São Paulo State].

    abstract:PURPOSE:To present the characteristics of individuals and the prevalence of ectropium eyelid in a random sample of the state of São Paulo, Brazil. METHODS:Data were collected during the Project on Prevention of Blindness, Faculty of Medicine of Botucatu - UNESP, a systematic random household sample was obtained. We ev...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:

    authors: Silva Cdo P,Schellini SA,Padovani CR,Narikawa S

    更新日期:2009-01-01 00:00:00

  • The relationship between topical anti-glaucoma medications and the development of lacrimal drainage system obstruction.

    abstract:PURPOSE:To evaluate whether any topical anti-glaucoma medications increase the risk of lacrimal drainage system obstruction or whether the presence of preservatives alone is sufficient to generate obstruction. METHODS:This nested case-control study compared a group of patients with lacrimal duct obstruction who receiv...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.5935/0004-2749.20180095

    authors: Ortiz-Basso T,Galmarini A,Vigo RL,Gonzalez-Barlatay JM,Premoli EJ

    更新日期:2018-11-01 00:00:00

  • Corneal biomechanical evaluation in healthy thin corneas compared with matched keratoconus cases.

    abstract:PURPOSE:To evaluate and compare corneal hysteresis (CH) and corneal resistance factor (CRF) in healthy eyes with a central corneal thickness (CCT) < 505 µm with CH and CRF in gender-, age-, and CCT-matched keratoconus cases, and to estimate the sensitivity and specificity of these parameters for discriminating between ...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492011000100003

    authors: Fontes BM,Ambrósio R Jr,Velarde GC,Nosé W

    更新日期:2011-01-01 00:00:00

  • Ocular blood flow and choroidal thickness changes after carotid artery stenting.

    abstract:PURPOSES:To evaluate changes in ocular blood flow and subfoveal choroidal thickness in patients with symptomatic carotid artery stenosis after carotid artery stenting. METHODS:We included 15 men (mean age, 63.6 ± 9.1 years) with symptomatic carotid artery stenosis and 18 healthy volunteers (all men; mean age, 63.7 ± 5...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.5935/0004-2749.20200081

    authors: Biberoglu E,Eraslan M,Midi I,Baltacioglu F,Bitargil M

    更新日期:2020-09-01 00:00:00

  • Pseudohypopyon immediately after intravitreal injection of triamcinolone acetonide--case reports.

    abstract::Report on the development of pseudohypopyon immediately after intravitreal injection of triamcinolone acetonide (TAAC). Two phakic patients presenting with a transient pseudohypopyon after having been treated with intravitreal triamcinolone. One had a clinically significant macular edema with cystoid component (CSME w...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492005000200018

    authors: Campos VE,Maia A,Muccioli C,Belfort R Jr

    更新日期:2005-03-01 00:00:00

  • [Penetrating keratoplasty indications in "Hospital das Clínicas-UNICAMP"].

    abstract:PURPOSE:To determine the main causes of penetrating keratoplasty indications at "Hospital das Clínicas-UNICAMP" (January, 1999 to December, 2003). METHODS:A non-comparative, retrospective series of case studies. The authors reviewed the files of 857 patients who underwent penetrating keratoplasty at "Hospital das Clín...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492007000300020

    authors: Flores VG,Dias HL,de Castro RS

    更新日期:2007-05-01 00:00:00

  • [Ethmoid sinus osteoma with orbital invasion: report of three cases and review of the literature].

    abstract::We report three rare cases of ethmoid osteoma extending to the medial quadrant of the orbit that had singular particularities, such as occurring in women, at an unusual age group, and complaint of epiphora. The radiographic images were typical of this condition. Patients were submitted to surgery with complete resolut...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,评审

    doi:10.1590/s0004-27492007000600027

    authors: Cordeiro de Carvalho CS,Schellini SA,Tagliarini JV,Nakajima V,Domingues MA

    更新日期:2007-11-01 00:00:00

  • Changes in corneal sensitivity following cross-linking for progressive early-stage keratoconus.

    abstract:PURPOSE:To evaluate changes in corneal sensitivity following corneal cross-linking (CXL) in patients with progressive earlier stage keratoconus. METHODS:Thirty-eight eyes of 19 patients (11 women, 8 men) were included in a prospective, nonrandomized clinical study. The mean patient age was 22 years (range, 18-26 years...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 临床试验,杂志文章

    doi:10.5935/0004-2749.20140021

    authors: Lago Ade M,Nassaralla BR,Stival LR,Nassaralla Junior JJ

    更新日期:2014-04-01 00:00:00

  • [Study of the data obtained on surgery to make an eyelid fold in oriental patients].

    abstract:PURPOSES:To describe a surgical technique utilized in a group of Oriental patients to create a crease in the superior eyelid, associated or not with a blepharoplasty, and to review the main factors to attain a satisfactory final result. METHODS:A retrospective study was made in 12 data of patients submitted to a surge...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492008000500010

    authors: Vieira GS,Moura Eda M,Van Baak A

    更新日期:2008-09-01 00:00:00

  • Assessing patient satisfaction with cataract surgery under topical anesthesia supplemented by intracameral lidocaine combined with sedation.

    abstract:PURPOSE:Ocular akinesia, the use of anticoagulants, and patient collaboration are some of the factors that must be taken into consideration when choosing the appropriate anesthesia for phacoemulsification cataract surgery. The satisfaction of patients with the use of topical anesthesia and conscious sedation for this p...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492013000600005

    authors: Fernandes MB,Souza RV,Vasconcelos GC,Ribeiro KG,Andrade BB,Fernandes CR

    更新日期:2013-11-01 00:00:00

  • [Structural features of macular eyes of preschoolers born preterm: analysis by optical coherence tomography, and indirect ophthalmoscopy].

    abstract:PURPOSE:Compare the retinal structure of the macula and fovea among premature infants with retinopathy of prematurity (ROP) stages II and III post treatment, premature infants with ROP stages II and III with spontaneous regression and premature infants without ROP, through optical coherence tomography (OCT) and binocul...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492013000200009

    authors: Bonotto LB,Moreira AT,Bortolotto CM

    更新日期:2013-03-01 00:00:00

  • Use of virtual reality equipment to assess the manual dexterity of applicants for ophthalmology residency.

    abstract:PURPOSE:To assess the microsurgery dexterity outcomes of two sequential training evaluations using virtual reality technology. METHODS:This was a multicenter cross-sectional study of all candidates who were accepted as first-year residents at one of six ophthalmology teaching institutions. Residents were subjected to ...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,多中心研究

    doi:10.5935/0004-2749.20200050

    authors: Vieira IV,Sakaya BN,Soares LVB,Chamon W

    更新日期:2020-08-01 00:00:00

  • Boston type I keratoprosthesis: Review.

    abstract::Regardless of significant progress in the field of corneal transplantation to treat corneal opacification, some cases of corneal blindness still present a poor prognosis for conventional penetrating keratoplasty. In patients with repeated graft failure and/or with severe ocular surface disease, the Boston type I kerat...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,评审

    doi:10.1590/s0004-27492012000300016

    authors: Magalhães FP,Sousa LB,Oliveira LA

    更新日期:2012-05-01 00:00:00

  • Relationship between diabetic retinopathy severity and the timespan between the endocrinopathy diagnosis and the first ophthalmic examination.

    abstract:PURPOSE:To investigate whether the time interval between type 2 diabetes mellitus (DM) diagnosis and the first fundoscopic examination is related with the presence and the severity of diabetic retinopathy (DR) observed. METHODS:A survey of 105 type 2 DM patients referred to ophthalmologic evaluation in the "Hospital d...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492010000300006

    authors: Preti RC,Motta AA,Maia OO Jr,Morita C,Nascimento VP,Monteiro ML,Takahashi WY

    更新日期:2010-05-01 00:00:00

  • Amblyopia: neural basis and therapeutic approaches.

    abstract::Abnormalities in visual processing caused by visual deprivation or abnormal binocular interaction may induce amblyopia, which is characterized by reduced visual acuity. Occlusion therapy, the conventional treatment, requires special attention as occlusion of the fellow normal eye may reduce its visual acuity and impai...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,评审

    doi:10.5935/0004-2749.20160099

    authors: Bretas CC,Soriano RN

    更新日期:2016-09-01 00:00:00

  • [Margin eyelid reconstruction with hard palate graft].

    abstract:PURPOSE:To investigate the advantages and the complications of the use of hard palate graft in the reconstruction of the inferior eyelids with large basocelular carcinoma. METHODS:Review of specialized articles and report of the technique used in the Oculoplastic Department of the "Hospital Santa Casa de Porto Alegre"...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,评审

    doi:10.1590/s0004-27492008000400009

    authors: Burmann TG,Marcon I,Rizzato T,Scheid K

    更新日期:2008-07-01 00:00:00

  • Visual loss resulting from immunosuppressive therapy in patients with syphilitic uveitis.

    abstract::Permanent visual loss can be caused by improper use of immunosuppressive therapy in cases of uveitis without differential diagnosis of syphilitic uveitis. We present four cases of syphilitic uveitis that were incorrectly diagnosed as being secondary to rheumatic diseases and were subsequently treated with immunosuppre...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.5935/0004-2749.20150047

    authors: Afonso VC,Nascimento H,Belfort RM,Sato EI,Muccioli C,Belfort R Jr

    更新日期:2015-05-01 00:00:00

  • [Traumatic optic nerve avulsion by high caliber bullet: case report].

    abstract::Traumatic optic nerve avulsion occurs most commonly after blunt ocular trauma. Optic nerve avulsion by high caliber bullet is exceptional and must be thought of in the management of those patients victims of gunshot wounds to the globe and orbit. The present paper reports the first documented case of this singular con...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章

    doi:10.1590/s0004-27492006000300025

    authors: Tárcia Rde A

    更新日期:2006-05-01 00:00:00