Abstract:
PURPOSES:To evaluate the effects of nalbuphine 1% on the expression of metalloproteinase 1 (MMP-1), metalloproteinase 9 (MMP-9), and opioid growth factor (OGF) in rabbit corneas after lamellar keratectomy. METHODS:The rabbits were assigned to two groups: group nalbuphine (GN, n=30), which received 30 µL of nalbuphine 1% in 4 daily applications at regular intervals until corneal epithelialization, and group control (GC, n=30), which received physiological saline solution under the same conditions adopted in GN. The corneas were collected for immunohistochemistry on days 1, 3, 5, 7, and 9 after lamellar keratectomy, and the expressions of MMP-1, MMP-9, and OGF were analyzed. RESULTS:The expressions of MMP-1 and MMP-9 increased until day 5 of the evaluation, with no differences observed between GN and GC (p>0.05). On days 7 and 9, significant reductions were observed in the expression of MMP-1 (p<0.01), with no differences observed between GN and GC (p>0.05). The expression of OGF was constant in all periods (p>0.05), restricted to the corneal epithelium, and there was no difference between the groups (p>0.05). CONCLUSIONS:The study results showed that nalbuphine 1% did not alter the expression patterns of MMP-1, MMP-9, and OGF in rabbit corneas after lamellar keratectomy.
journal_name
Arq Bras Oftalmoljournal_title
Arquivos brasileiros de oftalmologiaauthors
Silva ML,Ribeiro AP,Silva GA,Sanchez IX,Renzo R,Uscategui R,Lima TB,Aldrovani M,Laus JLdoi
10.5935/0004-2749.20150037subject
Has Abstractpub_date
2015-05-01 00:00:00pages
141-5issue
3eissn
0004-2749issn
1678-2925pii
S0004-27492015000300002journal_volume
78pub_type
杂志文章abstract:PURPOSE:To evaluate the knowledge and behaviors of ophthalmologists in Turkey concerning micronutrition support in patients with age related macular degeneration (ARMD). METHODS:This study involved 1,845 ophthalmologists. A scientific poll was sent to all participants by email. The survey covered the following: demogr...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de oftalmologia
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abstract::Ocular inflammation is one of the leading causes of blindness and loss of vision. Human uveitis is a complex and heterogeneous group of diseases characterized by inflammation of intraocular tissues. The eye may be the only organ involved, or uveitis may be part of a systemic disease. A significant number of cases are ...
journal_title:Arquivos brasileiros de oftalmologia
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abstract:PURPOSE:To determine the most common approach to repair the anophthalmic socket in Brazil, and to compare the data with the trends in other countries. METHODS:Exploratory study using electronic questionnaire sent by Internet to ophthalmologists members of the Brazilian Orbit and Oculoplastic Society (SBCPO). The recei...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492012000600004
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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doi:10.1590/s0004-27492008000200004
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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doi:10.1590/s0004-27492007000300020
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,多中心研究
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
doi:10.1590/s0004-27492008000400009
更新日期:2008-07-01 00:00:00
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20150047
更新日期:2015-05-01 00:00:00
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492006000300025
更新日期:2006-05-01 00:00:00