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Adverse drug reactions in a primary care population prescribed non-steroidal anti-inflammatory drugs.

Abstract：

OBJECTIVE:To determine how often patients with musculoskeletal (MSK) complaints prescribed a non-steroidal anti-inflammatory drug (NSAID) subsequently consult their general practitioner (GP) with a non-serious adverse drug reaction (ADR). DESIGN:Cohort study. SETTING:A healthcare database containing the electronic GP medical records of over 1.5 million patients throughout the Netherlands. PATIENTS:A total of 16 626 adult patients with MSK complaints prescribed an NSAID. MAIN OUTCOME MEASURES:The patients' medical records were manually assessed for the duration of NSAID use for a maximum of two months, and consultations for complaints predefined as potential ADRs were identified. Subsequently, the likelihood of an association with the NSAID use was assessed and these potential ADRs were categorized as likely, possible, or unlikely ADRs. RESULTS:In total, 961 patients (6%) consulted their GP with 1227 non-serious potential ADRs. In 174 patients (1%) at least one of these was categorized as a likely ADR, and in a further 408 patients (2.5%) at least one was categorized as a possible ADR. Dyspepsia was the most frequent likely ADR, followed by diarrhoea and dyspnoea (respectively 34%, 8%, and 8% of all likely ADRs). CONCLUSION:Of the patients with MSK complaints prescribed an NSAID, almost one in 30 patients re-consulted their GP with a complaint likely or possibly associated with the use of this drug. The burden of such consultations for non-serious ADRs should be taken into account by GPs when deciding whether treatment with an NSAID is appropriate.

journal_name

Scand J Prim Health Care

journal_title

Scandinavian journal of primary health care

authors

Koffeman AR,Van Buul AR,Valkhoff VE,Jong GW,Bindels PJ,Sturkenboom MC,Van der Lei J,Luijsterburg PA,Bierma-Zeinstra SM

doi

10.3109/02813432.2015.1067513

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

163-9

issue

3

eissn

0281-3432

issn

1502-7724

journal_volume

33

pub_type

杂志文章

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