Abstract：
:Repeated stress can trigger episodes of depression, along with symptoms of anhedonia and anxiety. Although often modeled separately, anxiogenic factors potently modulate hedonic, or appetitive, behavior. While repeated stress can increase anxiety and decrease appetitive behavior, it is not clear whether repeated stress can influence the impact of anxiogenic factors on appetitive behavior. This study tests whether repeated stress shifts behavior in a task that measures anxiogenic-appetitive balance. To test this, adult male rats were trained to lever press for sucrose pellet reward, and the effect of anxiogenic bright light on this behavior was measured. The impact of the bright light anxiogenic stimulus on lever pressing was compared between groups exposed to either daily repeated social defeat stress or control handling. We found that repeated stress reduced exploration in the open field and decreased social interaction, but had minimal effect on baseline lever pressing for reward. Repeated stress substantially enhanced the effect of anxiogenic bright light on lever pressing. This effect was greater two days after the last stress exposure, and began to diminish within two weeks. These data demonstrate that the anxiogenic and anhedonic features induced by repeated stress can be separately measured, and that the impact of anxiogenic stimuli can be greatly enhanced after repeated stress, even in the face of appetitive drive. The data also demonstrate that some apparent anhedonic-like effects of repeated stress can be due to increased sensitivity to anxiogenic stimuli, and may reflect an imbalance in an appetitive approach-withdrawal continuum.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Jaisinghani S,Rosenkranz JAdoi
10.1016/j.bbr.2015.04.048subject
Has Abstractpub_date
2015-09-01 00:00:00pages
172-9eissn
0166-4328issn
1872-7549pii
S0166-4328(15)00303-4journal_volume
290pub_type
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(96)00073-3
更新日期：1996-01-01 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.11.015
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pub_type： 杂志文章,评审
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journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章
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更新日期：1996-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-04-08 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2015-09-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112231
更新日期：2020-01-13 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2000-02-01 00:00:00
