Real-world evidence enhances decision making.

abstract：BACKGROUND:Medication therapy management (MTM) programs were first introduced as a result of the 2003 Medicare Prescription Drug Improvement and Modernization Act. Since then, the Centers for Medicare & Medicaid Services (CMS) have established minimum requirements for health plans to follow in establishing patient elig...

journal_title：Journal of managed care & specialty pharmacy

authors： Miller DE,Roane TE,Salo JA,Hardin HC

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Adherence to biologic disease-modifying antirheumatic drugs (bDMARDs) among patients with rheumatoid arthritis (RA) is often suboptimal in routine clinical practice. Low or nonadherence can reduce the effectiveness of bDMARD therapies. OBJECTIVE:To evaluate filling of newly prescribed initial bDMARDs for th...

journal_title：Journal of managed care & specialty pharmacy

authors： Harnett J,Wiederkehr D,Gerber R,Gruben D,Bourret J,Koenig A

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Acromegaly is a chronic disorder characterized by excess growth hormone secretion and elevated insulin-like growth factor-1 levels most often caused by a pituitary adenoma. Clinical presentation of the disease includes coarsening of the facial features, soft-tissue swelling of the hands and feet, and overgro...

journal_title：Journal of managed care & specialty pharmacy

authors： Placzek H,Xu Y,Mu Y,Begelman SM,Fisher M

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The introduction of anti-vascular endothelial growth factor (anti-VEGF) drugs to ophthalmology has revolutionized the treatment of neovascular age-related macular degeneration (nAMD). Despite this significant progress, gaps and challenges persist in the diagnosis of nAMD, initiation of treatment, and managem...

journal_title：Journal of managed care & specialty pharmacy

authors： Wykoff CC,Clark WL,Nielsen JS,Brill JV,Greene LS,Heggen CL

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Cancer is a leading cause of death with substantial financial costs. While significant data exist on the economic burden of care, less is known about the indirect costs of treatment and, specifically, the effect on work productivity of patients and their caregivers. To examine the full effect of cancer and t...

journal_title：Journal of managed care & specialty pharmacy

authors： Kamal KM,Covvey JR,Dashputre A,Ghosh S,Shah S,Bhosle M,Zacker C

更新日期：2017-02-01 00:00:00

abstract：:BACKGROUND: Nonadherence and nonpersistence to antidepressants in major depressive disorder (MDD) are common and associated with poor clinical and functional outcomes and increased health care resource utilization (HCRU) and costs. However, contemporary real-world evidence on the economic effect of antidepressant nona...

journal_title：Journal of managed care & specialty pharmacy

authors： Ta JT,Sullivan SD,Tung A,Oliveri D,Gillard P,Devine B

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:In 2013, it was reported that about 1 of every 3 U.S. adults has hypertension. Of these 70 million individuals, approximately 50% have their blood pressure under control. Achieving hypertension control, especially in at-risk populations, requires a multipronged approach that includes lifestyle modifications ...

journal_title：Journal of managed care & specialty pharmacy

authors： Lustig A,Ogden M,Brenner RW,Penso J,Westrich KD,Dubois RW

更新日期：2016-10-01 00:00:00

abstract：:Improving medication adherence has been identified as a crucial step towards improving health outcomes for patients with chronic disease and has provided the motivation for many changes in our health care system. Despite the volume of research done on this topic, however, we still lack important basic information abou...

journal_title：Journal of managed care & specialty pharmacy

authors： Seabury SA,Gupta CN,Philipson TJ,Henkhaus LE,PhRMA Medication Adherence Advisory Council.

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Encouraging generic drug use has reduced health care costs for payers and consumers, but the availability of therapeutically interchangeable medications or generic medications of choice is not equal across disease states. The extent to which systems of care are able to substitute with generics is not well un...

journal_title：Journal of managed care & specialty pharmacy

authors： Walton SM,Rash C,Lambert BL,Galanter WL

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Adherence to treatment is correlated with treatment success in chronic myeloid leukemia (CML). CVS Specialty explored novel methods to improve adherence in this population to ensure optimal adherence and lower the risk of unsuccessful treatment. One novel program explored involved an interactive 2-way clinic...

journal_title：Journal of managed care & specialty pharmacy

authors： Sawicki C,Friend KE,Patel R,Polinski JM,Singh S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Psoriasis is a chronic, hyper-proliferative dermatological condition associated with joint symptoms known as psoriatic arthritis (PsA). In a 2013 review, the total economic burden of PsA was estimated at $51.7-$63.2 billion. The economic burden of moderate to severe psoriasis patients has reduced significant...

journal_title：Journal of managed care & specialty pharmacy

authors： Lee S,Xie L,Wang Y,Vaidya N,Baser O

更新日期：2018-07-01 00:00:00

abstract：DISCLOSURES:No funding contributed to the writing of this commentary. Brandsema reports consulting for Alexion, Audentes, AveXis, Biogen, Cytokinetics, PTC Therapeutics, Sarepta, and WaVe and has received research funding as a site investigator from Alexion, AveXis, Biogen, CSL Behring, Cytokinetics, Fibrogen, Pfizer, ...

journal_title：Journal of managed care & specialty pharmacy

authors： Brandsema JF

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Accurate estimates of the effects of cost sharing on adherence to medications prescribed for use together, also called concurrent adherence, are important for researchers, payers, and policymakers who want to reduce barriers to adherence for chronic condition patients prescribed multiple medications concurre...

journal_title：Journal of managed care & specialty pharmacy

authors： Sacks NC,Burgess JF,Cabral HJ,McDonnell ME,Pizer SD

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Oral pharmacological treatment for overactive bladder (OAB) consists of antimuscarinics and the beta-3 adrenergic agonist mirabegron. Antimuscarinic adverse events (AEs) such as dry mouth, constipation, and blurry vision can result in frequent treatment discontinuation rates, leaving part of the OAB populati...

journal_title：Journal of managed care & specialty pharmacy

authors： Perk S,Wielage RC,Campbell NL,Klein TM,Perkins A,Posta LM,Yuran T,Klein RW,Ng DB

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Tisagenlecleucel was approved for the treatment of pediatric and young adult patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (ALL) based on the pivotal ELIANA trial. OBJECTIVE:To comprehensively evaluate the total costs associated with tisagenlecleucel treatment, including costs ...

journal_title：Journal of managed care & specialty pharmacy

authors： Yang H,Hao Y,Qi CZ,Chai X,Wu EQ

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is associated with substantial morbidity and mortality. With the rise in prevalence of diabetes, there has been an increased need for clinical pharmacy services focused on diabetes management in ambulatory clinics. However, more data IS needed to determine the overall impact that clinical p...

journal_title：Journal of managed care & specialty pharmacy

authors： Chung N,Rascati K,Lopez D,Jokerst J,Garza A

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Immunoglobulin (Ig) is a costly blood product prescribed as immune replacement or modulation therapy to treat a wide spectrum of medical conditions. While the FDA has approved Ig for a limited number of indications, there are multiple off-label uses that have demonstrated proven clinical benefit or are curre...

journal_title：Journal of managed care & specialty pharmacy

authors： Tonkovic B,Rutishauser LK

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Prostacyclins play an important role in the management of pulmonary arterial hypertension (PAH). Intravenous prostacyclin was the first disease-specific treatment for patients with PAH. Subcutaneous and nonparenteral (oral or inhaled) formulations have subsequently become available. However, data are lacking...

journal_title：Journal of managed care & specialty pharmacy

authors： Burger CD,Pruett JA,Lickert CA,Berger A,Murphy B,Drake W 3rd

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:The management of schizophrenia, a chronic, multifaceted mental health condition, is associated with considerable health care resource utilization (HCRU) and costs. Current evidence indicates that a high-risk and costly prodromal period, during which patients are likely symptomatic, precedes diagnosis. Bette...

journal_title：Journal of managed care & specialty pharmacy

authors： Wallace A,Barron J,York W,Isenberg K,Franchino-Elder J,Sidovar M,Sand M

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Research describing patient experience and outcomes with extended half-life recombinant factor VIII (EHL rFVIII) outside of clinical trials is limited. Real-world rFVIII consumption studies, when people with hemophilia A (PWHA) switch from standard half-life (SHL) to EHL rFVIII, may help payers and clinician...

journal_title：Journal of managed care & specialty pharmacy

authors： Aledort L,Milligan S,Watt M,Booth J

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The federal 340B Drug Discount Program provides access to significant drug price discounts for health care organizations in the United States that serve a disproportional share of disadvantaged patients. OBJECTIVE:To analyze trends over a 10-year period (2006~2016) in the price of specialty drugs, contrasti...

journal_title：Journal of managed care & specialty pharmacy

authors： Lee CH,Chang J,McCombs J

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Psoriatic arthritis (PsA) is associated with multiple comorbid conditions, including cardiovascular (CV) comorbidities that impose a considerable burden on patients. Effective management of PsA requires an understanding of comorbidity profiles. OBJECTIVE:To compare the frequency and incidence rates of comor...

journal_title：Journal of managed care & specialty pharmacy

authors： Kaine J,Song X,Kim G,Hur P,Palmer JB

更新日期：2019-01-01 00:00:00

abstract：:BACKGROUND: Basal insulin is often recommended as the initial therapy for patients with type 2 diabetes who require insulin treatment. Adequate adherence is critical to diabetes management, yet suboptimal insulin adherence has been reported. Second-generation long-acting (SGLA) insulin has higher dosing flexibility an...

journal_title：Journal of managed care & specialty pharmacy

authors： Zhang H,Barner JC,Moczygemba LR,Rascati KL

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Employers have increased efforts to engage employees in health and wellness programs. Providing employees with incentives to participate in these programs has been shown to improve overall enrollment and engagement. One program that has had challenges with enrollment and engagement is medication therapy mana...

journal_title：Journal of managed care & specialty pharmacy

authors： Tomaszewski D,Cernohous T,Vaidyanathan R

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Recent evidence has demonstrated that, over 12 months, pharmacy costs associated with switching nonadherent recently relapsed patients from oral atypical antipsychotics (OAAs) to once-monthly paliperidone palmitate (PP1M) were offset by reduced relapse rates and schizophrenia-related health care costs. In ad...

journal_title：Journal of managed care & specialty pharmacy

authors： El Khoury AC,Pilon D,Morrison L,Shak N,Llaneza A,Kim E,Lefebvre P

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Since multiple myeloma (MM) incurs a substantial economic burden in care management, more and more discussion has been generated in recent years about the costs of novel antimyeloma drugs and their associated value. Because of these costs, economic assessment that quantifies value of care over the long-term ...

journal_title：Journal of managed care & specialty pharmacy

authors： Chen Y,Lairson DR,Chan W,Huo J,Du XL

更新日期：2017-08-01 00:00:00

abstract：DISCLOSURES:The author provides consulting services to the pharmaceutical industry, including manufacturers, health plans, employers, and specialty pharmacies, and is a member of the editorial advisory board of Specialty Pharmacy News. The author reports no financial or other conflicts of interest related to the subjec...

journal_title：Journal of managed care & specialty pharmacy

authors： Rubinstein E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Formulary management within a limited budget is critical, especially for specialty drugs, which are used for serious medical conditions and are very expensive. Despite attempts to summarize the pertinent evidence, it is uncertain whether data needs of formulary decision makers for specialty drugs are satisfi...

journal_title：Journal of managed care & specialty pharmacy

authors： Choi Y,Navarro RP

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Rosacea is a chronic skin disorder that presents with abnormal vascular and inflammatory conditions. Clinical manifestations include flushing, facial erythema, inflammatory papules and pustules, telangiectasias, edema, and watery or irritated eyes. OBJECTIVE:To discuss the evolving pathophysiology of rosace...

journal_title：Journal of managed care & specialty pharmacy

authors： Feldman SR,Huang WW,Huynh TT

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The accountable care organization (ACO) is an innovative health care delivery model centered on value-based care. ACOs consisting of primary care providers are increasingly becoming commonplace in practice; however, medication management remains suboptimal. PROGRAM DESCRIPTION:As experts in medication manag...

journal_title：Journal of managed care & specialty pharmacy

authors： Joseph T,Hale GM,Eltaki SM,Prados Y,Jones R,Seamon MJ,Moreau C,Gernant SA

更新日期：2017-05-01 00:00:00