Resolvin D1 Reduces Infarct Size Through a Phosphoinositide 3-Kinase/Protein Kinase B Mechanism.

abstract：INTRODUCTION:Newly emerging evidence showed that glucocorticoids could potentiate natriuretic peptides' action by increasing the density of natriuretic peptide receptor A, leading to a potent diuresis and a renal function improvement in patients with acute decompensated heart failure (ADHF). Therefore, glucocorticoid t...

journal_title：Journal of cardiovascular pharmacology

authors： Liu C,Liu K,COPE-ADHF Study Group.

更新日期：2014-04-01 00:00:00

abstract：:The preproendothelin-1 (preproET-1) gene is induced by thrombin after phosphorylation of nonreceptor protein tyrosine kinase pathways. This study investigated the contribution of Ca2+/calmodulin-dependent intracellular signaling cascades to this pathway and measured ET-1 mRNA levels by Northern blot analysis in human ...

journal_title：Journal of cardiovascular pharmacology

authors： Marsen TA,Simonson MS,Dunn MJ

更新日期：1995-01-01 00:00:00

abstract：:We aim to develop warfarin dosing algorithm for African-Americans. We explored demographic, clinical, and genetic data from a previously collected cohort of 163 African-American patients with a stable warfarin dose. We explored 2 approaches to develop the algorithm: multiple linear regression and artificial neural net...

journal_title：Journal of cardiovascular pharmacology

authors： Alzubiedi S,Saleh MI

更新日期：2016-01-01 00:00:00

abstract：:The cardioprotective effect of angiotensin-converting enzyme (ACE) inhibitors in cardiac ischemia/reperfusion damage is assumed to result largely from inhibition of the enzymatic breakdown of endogenous bradykinin (BK). We assessed the role of nitric oxide (NO) in mediating the beneficial actions of BK and the possibl...

journal_title：Journal of cardiovascular pharmacology

authors： Massoudy P,Becker BF,Gerlach E

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:The present study has been designed to investigate the effect of sodium cromoglycate and ketotifen, mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats. METHODS:Rats were administered L-methionine (1.7 g/kg/day PO) for 8 weeks to produce hyperhomocysteinemia. Sodium cromoglycat...

journal_title：Journal of cardiovascular pharmacology

authors： Singh AP,Singh M,Balakumar P

更新日期：2008-06-01 00:00:00

abstract：:The renin-angiotensin system (RAS) plays an important role in blood pressure control and in water and salt homeostasis. It is involved in the pathophysiology of hypertension and structural alterations of the vasculature, kidney, and heart, including neointima formation, nephrosclerosis, postinfarction remodeling, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Stroth U,Unger T

更新日期：1999-01-01 00:00:00

abstract：:We examined the involvement of the oxidative stress in high glucose-induced suppression of human aortic endothelial cell proliferation. Chronic glucose treatment for 72 h concentration-dependently (5.6-22.2 mol/l) inhibited human coronary endothelial cell proliferation. Temocaprilat, an angiotensin-converting enzyme i...

journal_title：Journal of cardiovascular pharmacology

authors： Yasunari K,Maeda K,Watanabe T,Nakamura M,Asada A,Yoshikawa J

更新日期：2003-12-01 00:00:00

abstract：:Experience with angiotensin converting enzyme (ACE) inhibitor drugs as with other antihypertensive agents, is limited in the elderly. Nevertheless, they appear effective and well tolerated but without evidence to suggest that they have any special role in the elderly compared to a younger age group. Most are excreted ...

journal_title：Journal of cardiovascular pharmacology

authors： Ball SG

更新日期：1988-01-01 00:00:00

abstract：:Oxidative stress is believed to play a role in diabetes-induced vascular complications. In this study, we tested whether chronic treatment with a known hydroxyl radical scavenger, dimethylthiourea (DMTU), could prevent endothelial dysfunction in diabetes. Lewis strain rats were made diabetic by an intravenous injectio...

journal_title：Journal of cardiovascular pharmacology

authors： Pieper GM,Siebeneich W,Roza AM,Jordan M,Adams MB

更新日期：1996-12-01 00:00:00

abstract：:Gamma-hydroxybutyrate (GHB) is generally thought to be a central nervous system depressant; however, GHB also has sympathomimetic cardiovascular actions. Radio telemetry was used to record the cardiovascular responses elicited by GHB (180-1000 mg/kg IV) in conscious rats. GHB elicited increases in mean arterial pressu...

journal_title：Journal of cardiovascular pharmacology

authors： Hicks AR,Kapusta DR,Varner KJ

更新日期：2004-12-01 00:00:00

abstract：:Baroreflex control of renin release following acute and prolonged blood pressure reduction by felodipine administration was investigated in conscious spontaneously hypertensive rats (SHR) fitted with arterial and venous catheters. Basal values of mean arterial pressure (MAP), heart rate (HR), and plasma renin activity...

journal_title：Journal of cardiovascular pharmacology

authors： Nordlander M,Horton R,Thalén P

更新日期：1987-01-01 00:00:00

abstract：:Beraprost sodium is a stable analog of the vasodilator, platelet antiaggregatory eicosanoid, prostacyclin. Experiments were performed to determine whether long-term therapy with beraprost produces vascular protective effects in saline-drinking stroke-prone spontaneously hypertensive rats (SHRSPs). Oral beraprost at 30...

journal_title：Journal of cardiovascular pharmacology

authors： Stier CT Jr,Chander PN,Belmonte A,Inamdar RS,Mistry M

更新日期：1997-09-01 00:00:00

abstract：:The antiischemic and antiarrhythmic effects of alinidine and a number of novel alinidine analogs were examined by using perfused rat-heart models. In the isolated working rat heart, the alinidine analog TH91:21 (10 microM; a butyl derivative) significantly increased the postischemic recovery of the heart in terms of b...

journal_title：Journal of cardiovascular pharmacology

authors： Challinor-Rogers JL,Rosenfeldt FL,Du XJ,McPherson GA

更新日期：1997-04-01 00:00:00

abstract：:The bronchopulmonary and pressor effects of endothelin-1 (ET-1), a newly described vasoconstrictor peptide produced by endothelial cells, were investigated in the guinea pig. Intravenous injection of ET-1 (1 nmol/kg) induced an increase in pulmonary inflation pressure (PIP) as well as an important and sustained increa...

journal_title：Journal of cardiovascular pharmacology

authors： Braquet P,Touvay C,Lagente V,Vilain B,Pons F,Hosford D,Chabrier PE,Mencia-Huerta JM

更新日期：1989-01-01 00:00:00

abstract：:The effects of angiotensin-converting enzyme inhibitor captopril on infarct size and cardiovascular hemodynamics were studied in 35 conscious dogs subjected to 24 h of coronary occlusion. Following occlusion of the left anterior descending coronary artery, 10 dogs were infused with captopril 0.25 mg/kg/h i.v. (group 1...

journal_title：Journal of cardiovascular pharmacology

authors： Daniell HB,Carson RR,Ballard KD,Thomas GR,Privitera PJ

更新日期：1984-11-01 00:00:00

abstract：:The beta-blocking activity of flestolol was established during increasing isoprenaline infusions and during graded physical exercise in conscious, chronically instrumented dogs. After a control cycle, flestolol was infused at three doses (1, 2.67, and 10 micrograms/kg/min). Flestolol has an extremely short half-life, ...

journal_title：Journal of cardiovascular pharmacology

authors： Grohs JG,Fischer G,Raberger G

更新日期：1990-02-01 00:00:00

abstract：:MDL 19205 4-ethyl-1-,3-dihydro-5-(4-pyridinylcarbonyl)-2H-imidazol-2-one, a new cardioactive agent, has been shown to increase myocardial contractile force in animals. It is effective by both oral and intravenous routes. We studied 11 patients with congestive heart failure--in 10 cases owing to coronary artery disease...

journal_title：Journal of cardiovascular pharmacology

authors： Cottier C,Follath F,Kiowski W,Pfisterer M,Emmenegger H,Burkart F

更新日期：1987-02-01 00:00:00

abstract：:Exposure of endothelial cells (ECs) to thrombin or cytokines leads to major changes in their biochemical properties, which confer procoagulant activities. Stimulated ECs express the procoagulant glycoprotein tissue factor (TF). Although some TF is expressed on the apical surface of the cells, most is deposited as a cr...

journal_title：Journal of cardiovascular pharmacology

authors： Leclerc NE,Haan-Archipoff G,Lenoble M,Beretz A

更新日期：1995-01-01 00:00:00

abstract：:The vasodilator action of organic nitrates can be severely impaired by induction of drug tolerance. A critical depletion of sulfhydryl groups has been proposed to play a key role in impairment of the biotransformation of organic nitrates to nitric oxide (NO). We studied the effects of the new cysteine-containing nitra...

journal_title：Journal of cardiovascular pharmacology

authors： Zanzinger J,Feelisch M,Bassenge E

更新日期：1994-05-01 00:00:00

abstract：:Phosphoinositide (PI) turnover, chronotropic and inotropic responses to alpha 1-adrenoceptor activation, and alpha 1-adrenoceptor density were studied in atria from rats with left ventricular myocardial infarction (LVMI) and noninfarcted rats. LVMI was produced after surgical ligation of the left coronary artery in 8-...

journal_title：Journal of cardiovascular pharmacology

authors： Rowley KG,Tung LH,Hodsman GP,Howes LG,Jarrott B,Beart PM,Louis WJ

更新日期：1991-03-01 00:00:00

abstract：:Autoradiographical images of whole body sections from control mice (29 +/- 3 days old) revealed high ETA densities within the cardiovascular system, with ETB receptors predominating in the kidney. A similar distribution of ETA receptors was found in ETB-deficient mice (25 +/- 2 days old) but the density was reduced in...

journal_title：Journal of cardiovascular pharmacology

authors： Davenport AP,Kuc RE

更新日期：2004-11-01 00:00:00

abstract：:In conscious, spontaneously hypertensive rats (SHR) oral prazosin (0.03-3.0 mg/kg) resulted in dose-related reductions of systolic blood pressure measured with a tail cuff. In SHR whose tail artery blood pressure was continuously monitored the antihypertensive effect of prazosin (1.0 mg/kg, p.o.) was accompanied by a ...

journal_title：Journal of cardiovascular pharmacology

authors： Lefèvre-Borg F,Roach AG,Gomeni R,Cavero I

更新日期：1979-01-01 00:00:00

abstract：:The sensitivity of smooth muscle from aortas of spontaneously hypertensive rats (SHR), renal hypertensive rats: two kidney-one clip and one kidney-one clip (2K-1C, 1K-1C) and DOCA salt hypertensive rats to the relaxant effect of nifedipine (NIF) was studied. A parallel leftward shift of the concentration-relaxation cu...

journal_title：Journal of cardiovascular pharmacology

authors： Cattaneo EA,Rinaldi GJ,Gende OA,Venosa RA,Cingolani HE

更新日期：1986-09-01 00:00:00

abstract：:Bromocriptine, a dopamine (DA) receptor agonist, has been reported to have hypotensive effects in anesthetized and conscious normotensive rats but its mechanism of action is still not fully understood. Therefore, we studied the changes in mean arterial blood pressure (MAP) and heart rate (HR) elicited by an intravenou...

journal_title：Journal of cardiovascular pharmacology

authors： Lahlou S,Demenge P

更新日期：1991-09-01 00:00:00

abstract：:Carvedilol is a dual-acting drug designed to produce two complementary effects: beta-blockade and vasodilation. These effects are induced in the same dose range, a prerequisite for utilizing both properties in an appropriate manner. The vasodilation is mediated predominantly by specific alpha 1-adrenoceptor blockade. ...

journal_title：Journal of cardiovascular pharmacology

authors： Sponer G,Strein K,Bartsch W,Müller-Beckmann B

更新日期：1992-01-01 00:00:00

abstract：:We investigated the effects of sodium 2[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (POCA) on regional myocardial function and metabolism in anesthetized, thoracotomized dogs subjected to a 53.5% reduction in flow through the circumflex branch of the left coronary artery (LCX). Regional function in the area suppl...

journal_title：Journal of cardiovascular pharmacology

authors： Seitelberger R,Kraupp O,Winkler M,Brugger G,Raberger G

更新日期：1985-03-01 00:00:00

abstract：:It has previously been shown that endothelin (ET)-receptor antagonists protect the myocardium from ischemia and reperfusion (I/R) injury. The mechanism behind this effect is unclear. The aim of this study was to elucidate the possible interaction between ET(A)-receptor antagonism and nitric oxide (NO) during I/R. Anes...

journal_title：Journal of cardiovascular pharmacology

authors： Gonon AT,Gourine AV,Pernow J

更新日期：2000-09-01 00:00:00

abstract：:Nebivolol, a chemically novel beta 1-adrenoceptor antagonist, acutely lowers blood pressure in spontaneously hypertensive rats, anaesthetised normotensive dogs, and hypertensive patients. We have investigated the actions of dl-nebivolol in five conscious normotensive rabbits (sham, mean blood pressure (BP) of 82.2 +/-...

journal_title：Journal of cardiovascular pharmacology

authors： Ward JE,Coles P,Cox H,Eisenhofer G,Angus JA

更新日期：1992-07-01 00:00:00

abstract：:The authors studied the involvement of IKr potassium current in ventricular fibrillation during perfusion. Electrophysiologic parameters were measured before and after dofetilide administration (2.5, 7.5, and 12.5 x 10-7 M, n = 8) in isolated perfused feline hearts. During pacing, these parameters included epicardial ...

journal_title：Journal of cardiovascular pharmacology

authors： Amitzur G,Shenkar N,Leor J,Novikov I,Eldar M

更新日期：2003-06-01 00:00:00

abstract：UNLABELLED:The role of mitochondrial transporters in the cardioprotection of rat hearts exposed to high [K+]-low [Ca2+]-cardioplegia (CPG) and ischemia and reperfusion (I/R) was studied through the mechano-energetic consequences of target drugs. The total heat rate (Ht) and the left intraventricular pressure (LVP) were...

journal_title：Journal of cardiovascular pharmacology

authors： Ragone MI,Consolini AE

更新日期：2009-09-01 00:00:00